Results 121 to 130 of about 31,592 (359)
Insights into the mechanisms of electromediated gene delivery and application to the loading of giant vesicles with negatively charged macromolecules [PDF]
arXiv, 2011 We present experimental results regarding the electrotransfer of plasmid DNA into phosphatidylcholine giant unilamellar vesicles (GUVs). Our observations indicate that a direct entry is the predominant mechanism of electrotransfer. A quantitative analysis of the DNA concentration increments inside the GUVs is also performed, and we find that our ...
arxiv
Advanced Energy Materials, EarlyView.Innovations are crucial for transferring high power conversion efficiencies (PCEs) to large‐scale perovskite devices. Here, a 2D regulated gas flow control for batch‐drying of slot‐die‐coated perovskite films is introduced. This drying method achieves homogeneous, pinhole‐free large‐area perovskite/silicon tandem solar cells and perovskite solar ...
Kristina Geistert +8 more
wiley +1 more source
Fluctuations in lipid bilayers: Are they understood?
, 2013 We review recent computer simulation studies of undulating lipid bilayers. Theoretical interpretations of such fluctuating membranes are most commonly based on generalized Helfrich-type elastic models, with additional contributions of local "protrusions"
Schmid, Friederike
core +1 more source
Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities
Asian Journal of Organic Chemistry, EarlyView.Diglycerides of natural organic acids and phenols were synthesized regio‐selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglycerides to exhibit not only the physiological activities of each constituent organic acid but also the ...
Jisu Hong +10 more
wiley +1 more source
Short-chain phospholipids as detergents [PDF]
, 2000 The physico-chemical properties of short-chain phosphatidylcholine are reviewed to the extent that its biological activity as a mild detergent can be rationalized.
Hauser, Helmut
core +1 more source
PLoS ONE, 2020 Progressive multifocal leukoencephalopathy (PML), caused by JC polyomavirus, is a demyelinating disease of the central nervous system that primarily affects oligodendrocytes. It can cause significant morbidity and mortality. An early diagnosis is of high
Yi Luo +7 more
doaj +1 more source
Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism
Annals of Neurology, EarlyView.Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo +7 more
wiley +1 more source
Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. [PDF]
, 2019 Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. NAFLD covers a spectrum that ranges from simple steatosis, nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis,
Alonso, Cristina +3 more
core
The Journal of Clinical Investigation, 2022 Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins (SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In this study, we assessed the impact of SREBP inhibition on NASH and liver cancer
Satoshi Kawamura +25 more
doaj +1 more source
Model plasma membrane indicates the inner leaflet is poised to initiate compositional heterogeneities [PDF]
arXiv, 2016 We investigate a model of an asymmetric bilayer consisting of sphigomyelin, phosphatidylcholine, and cholesterol in the outer leaflet, and phosphatidyl\-ethanolamine, (PE), phosphatidylserine, and cholesterol in the inner leaflet. Composition fluctuations are coupled to membrane fluctuations via the bending energy which depends upon the local ...
arxiv