Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes [PDF]
Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association ...
Floegel, Anna+7 more
core +1 more source
Probing the role of C-1 ester group in Naja naja phospholipase A2-phospholipid interactions using butanetriol-containing phosphatidylcholine analogues [PDF]
To understand the role of the ester moiety of the sn-1 acyl chain in phospholipase A2-glycerophospholipid interactions, we introduced an additional methylene residue between the glycerol C1 and C2 carbon atoms of phosphatidylcholines, and then studied ...
Arora, Ashish+2 more
core +1 more source
A rapid isocratic method for determining the total phosphatidylcholine and disaturated phosphatidylcholine levels in lung surfactant preparations by high performance liquid chromatography (HPLC) is described.
J Scarim, H Ghanbari, V Taylor, G Menon
doaj
In this data article we provide topologies and force field parameters files for molecular dynamics simulations of lipids in the OPLS-aa force field using the GROMACS package.
Waldemar Kulig+2 more
doaj +1 more source
Non‐targeted metabolite profiling reveals biochemical diversity of three East Asian mosses
Mosses are known for their bioactive composition and adaptation to environmental stresses. This study explores the metabolic diversity of three East Asian moss species, Niphotrichum japonicum, Calohypnum plumiforme, and Polytrichum formosum, using high‐resolution mass spectrometry. Lipids, particularly unsaturated fatty acids linked to cold adaptation,
Fatima Tuz Zahra+5 more
wiley +1 more source
Improved method for the synthesis of phosphatidylcholines.
An improved method for the synthesis of phosphatidylcholines from phosphatidic acid and choline is described. The technique utilizes the tetraphenylborate salt of choline together with the condensing agent 2,4,6-triisopropylbenzenesulfonyl chloride.
G S Harbison, R G Griffin
doaj
The contribution of extracellular RNA and its derived biomaterials in disease management
The implications of exRNA's biological function and the structural uniqueness of RNA help establish a close connection between RNA, material, and modern medicine. Abstract The RNA found in the circular system is known as extracellular RNA (exRNA). This kind of RNA has been found to play a biological role similar to that of a messenger. They can be used
Yu Wei+8 more
wiley +1 more source
The basic fragmentation mechanisms occurring in the mass spectra of the phosphatidylcholines have been described previously, and evidence was adduced to show that many of the more abundant ions are related by electron impact-induced processes.
R.A. Klein
doaj
Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah+9 more
wiley +1 more source
The Structure of Lipids and Proteins Studied by Attenuated Total Reflection (ATR) Infrared Spectroscopy II. Oriented Layers of a Homologous Series: Phosphatidylethanolamine to Phosphatidylcholine [PDF]
U. P. Fringeli
openalex +1 more source