Results 21 to 30 of about 10,346 (145)

Serum antibodies to phosphatidylcholine in MS [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2020
To evaluate the value of serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies reactive with phosphatidylcholine (PC) and lactosylceramide (LC) as biomarkers in MS.We developed an ultrasensitive ELISA technique to analyze serum IgG and IgM antibodies to LC and PC, which we used to analyze samples from 362 patients with MS, 10 patients with
Maria Cruz Sádaba, Veit Rothhammer, Úrsula Muñoz, Cristina Sebal, Esther Escudero, Pia Kivisäkk, Maria Isabel Garcia Sanchez, Guillermo Izquierdo, Stephen L. Hauser, Sergio E. Baranzini, Jorge R. Oksenberg, Roberto Álvarez-Lafuente, Rohit Bakshi, Howard L. Weiner, Francisco J. Quintana   +14 more
openaire   +6 more sources

Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents. [PDF]

PLoS ONE, 2016
The synthesis of novel phosphatidylcholines with geranic and citronellic acids in sn-1 and sn-2 positions is described. The structured phospholipids were obtained in high yields (59-87%) and evaluated in vitro for their cytotoxic activity against several
Anna Gliszczyńska, Natalia Niezgoda, Witold Gładkowski, Marta Czarnecka, Marta Świtalska, Joanna Wietrzyk   +5 more
doaj   +1 more source

Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease

Metabolites, 2022
(1) Background: This work aims to investigate the metabolomic changes in PIGinH11 pigs and investigate differential compounds as potential therapeutic targets for metabolic diseases.
Jianping Xu, Kaiyi Zhang, Bintao Qiu, Jieying Liu, Xiaoyu Liu, Shulin Yang, Xinhua Xiao   +6 more
doaj   +1 more source

Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery

Frontiers in Neurology, 2022
Stroke is a serious global public health issue, associated with severe disability and high mortality rates. Its early detection is challenging, and no effective biomarkers are available.
Meiling Huang, Shaohang Xu, Mingchao Zhou, Jiao Luo, Fubing Zha, Linlin Shan, Qingqing Yang, Baojin Zhou, Yulong Wang   +8 more
doaj   +1 more source

Expansion of Phosphatidylcholine and Phosphatidylserine/Phosphatidylcholine Monolayers by Differently Charged Amphiphiles [PDF]

Zeitschrift für Naturforschung C, 2001
Abstract Monolayer Technique, Nonionic Detergent, Erythrocyte Shape The degree and time-course of expansion of palmitoyloleoylphosphatidylcholine (PC) and bovine brain phosphatidylserine (PS)/PC (75:25, mol/mol) monolayers at 32 mN/m caused by differently charged amphiphiles (detergents) added to the sub-phase buffer (pH 7.4, 22 °C ...
K Bialkowska, Henry Hägerstrand, Malgorzata Bobrowska-Hägerstrand   +2 more
openaire   +2 more sources

Effects of diacylglycerols on conformation of phosphatidylcholine headgroups in phosphatidylcholine/phosphatidylserine bilayers

Biophysical Journal, 1995
The effects of five diacylglycerols (DAGs), diolein, 1-stearoyl,2-arachidonoyl-sn-glycerol, dioctanoylglycerol, 1-oleoyl,2-sn-acetylglycerol, and dipalmitin (DP), on the structure of lipid bilayers composed of mixtures of phosphatidylcholine and phosphatidylserine (4:1 mol/mol) were examined by 2H nuclear magnetic resonance (NMR ...
Dan Borchardt, D.S. Lester, Raphael Zidovetzki, Edward M. Goldberg   +3 more
openaire   +2 more sources

Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review

Frontiers in Medicine
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c ...
Liang Wu, Sheng-Cai Zhu, Yang He, Yun-Xia Zhu, Xiao-Liang Ou-Yang, Deng Zhang, Chun-Ming Li   +6 more
doaj   +1 more source

Functional, transcriptomic, and lipidomic studies of the choC gene encoding a phospholipid methyltransferase in Aspergillus fumigatus

Microbiology Spectrum
Phosphatidylcholines (PCs) are a class of cell membrane phospholipids playing important roles in cellular integrity and signaling. In eukaryotes, PCs are biosynthesized via the Kennedy cytidine nucleotide and the Bremer-Greenberg pathways.
Jiao Pan, Xinyu Yang, Cuiting Hu, Tongtong Fu, Xiuyan Zhang, Zijun Liu, Yu Wang, Fengyu Zhang, Xiaoyuan He, Jae-Hyuk Yu   +9 more
doaj   +1 more source

Miscibility of Phosphatidylcholines in Bilayers: Effect of Acyl Chain Unsaturation

Membranes, 2023
The miscibility of phospholipids in a hydrated bilayer is an issue of fundamental importance for understanding the organization of biological membranes. Despite research on lipid miscibility, its molecular basis remains poorly understood.
Agata Żak, Natan Rajtar, Waldemar Kulig, Mariusz Kepczynski   +3 more
doaj   +1 more source

Anti-inflammatory Effects of Phosphatidylcholine [PDF]

Journal of Biological Chemistry, 2007
We recently showed that mucus from patients with ulcerative colitis, a chronic inflammatory disorder of the colon, is characterized by a low level of phosphatidylcholine (PC) while clinical studies reveal that therapeutic addition of PC using slow release preparations is beneficial. The positive role of PC in this disease is still elusive.
Treede, Irina, Braun, Annika, Sparla, Richard, Kuehnel, Mark, Giese, Thomas, Turner, Jerrold R., Anes, Elsa, Kulaksiz, Hasan, Fuellekrug, Joachim, Stremmel, Wolfgang, Griffiths, Gareth, Ehehalt, Robert   +11 more
openaire   +4 more sources