Results 21 to 30 of about 33,361 (336)

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles [PDF]

, 2013
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest
Adamski, J. (Jerzy), Aulchenko, Y.S. (Yurii), Axenovich, T.I. (Tatiana), Biloglav, Z. (Zrinka), Broer, L. (Linda), Campbell, H. (Harry), Campbell, S. (Susan), Demirkan, A. (Ayşe), Dharuri, H. (Harish), Domingues, I. (Inês), Duijn, C.M. (Cornelia) van, Floyd, J. (Jamie), Franke, L. (Lude), Franklin, C.S. (Christopher), Gieger, C. (Christian), Gnewuch, C. (Carsten), Gyllensten, U. (Ulf), Hastie, N. (Nick), Hayward, C. (Caroline), Henneman, P. (Peter), Hettne, K.M. (Kristina), Hicks, A.A. (Andrew), Hoen, P.A.C. (Peter) 't, Hofman, A. (Albert), Huffman, J.E. (Jennifer), Igl, W. (Wilmar), Isaacs, A.J. (Aaron), Jansen, R.C. (Ritsert), Janssens, A.C.J.W. (Cécile), Johansson, A. (Åsa), Jonasson, I. (Inger), Karssen, L.C. (Lennart), Kirichenko, A.V. (Anatoly), Klinken, J.B. (Jan) van, Kolcic, I. (Ivana), Liebisch, G. (Gerhard), Meitinger, T. (Thomas), Mook-Kanamori, D.O. (Dennis), Oostra, B.A. (Ben), Pattaro, C. (Cristian), Pfeufer, A. (Arne), Pichler, I. (Irene), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Rivadeneira Ramirez, F. (Fernando), Roos, M. (Marco), Rudan, I. (Igor), Schmitz, G. (Gerd), Struchalin, M.V. (Maksim), Suhre, K. (Karsten), Ugocsai, P. (Peter), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Wang-Sattler, R. (Rui), Wild, S.H. (Sarah), Willems van Dijk, J.A.P. (Ko), Wilson, J.F. (James F), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Zaboli, G. (Ghazal), Zorkoltseva, I.V. (Irina)   +60 more
core   +1 more source

p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1

Cells, 2022
Altered lipid metabolism is a hallmark of cancer. p73, a p53 family member, regulates cellular processes and is expressed as multiple isoforms. However, the role of p73 in regulating lipid metabolism is not well-characterized.
Zachary Rabow, Kyra Laubach, Xiangmudong Kong, Tong Shen, Shakur Mohibi, Jin Zhang, Oliver Fiehn, Xinbin Chen   +7 more
doaj   +1 more source

Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy [PDF]

, 2015
Pregnancy is characterized by a complexity of metabolic processes that may impact fetal development and ultimately, infant health outcomes. However, our understanding of whole body maternal and fetal metabolism during this critical life stage remains ...
Ashton, Nick, Buss, Claudia, Entringer, Sonja, Hellmuth, Christian, Koletzko, Berthold, Lindsay, Karen L, Uhl, Olaf, Wadhwa, Pathik D   +7 more
core   +10 more sources

Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease

Metabolites, 2022
(1) Background: This work aims to investigate the metabolomic changes in PIGinH11 pigs and investigate differential compounds as potential therapeutic targets for metabolic diseases.
Jianping Xu, Kaiyi Zhang, Bintao Qiu, Jieying Liu, Xiaoyu Liu, Shulin Yang, Xinhua Xiao   +6 more
doaj   +1 more source

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects [PDF]

, 2016
Humans are exposed to a large number of environmental chemicals in their daily life, many of which are readily detectable in blood or urine. It remains uncertain if these chemicals can cause adverse health effects when present together at low doses.
Egebjerg, Karen Mandrup, Frandsen, Henrik Lauritz, Frederiksen, Hanne, Hadrup, Niels, Pedersen, Mikael, Skov, Kasper, Svingen, Terje, Vinggaard, Anne Marie   +7 more
core   +2 more sources

Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents. [PDF]

PLoS ONE, 2016
The synthesis of novel phosphatidylcholines with geranic and citronellic acids in sn-1 and sn-2 positions is described. The structured phospholipids were obtained in high yields (59-87%) and evaluated in vitro for their cytotoxic activity against several
Anna Gliszczyńska, Natalia Niezgoda, Witold Gładkowski, Marta Czarnecka, Marta Świtalska, Joanna Wietrzyk   +5 more
doaj   +1 more source

Lysophosphatidylcholines and phosphatidylcholines as biomarkers for stroke recovery

Frontiers in Neurology, 2022
Stroke is a serious global public health issue, associated with severe disability and high mortality rates. Its early detection is challenging, and no effective biomarkers are available.
Meiling Huang, Shaohang Xu, Mingchao Zhou, Jiao Luo, Fubing Zha, Linlin Shan, Qingqing Yang, Baojin Zhou, Yulong Wang   +8 more
doaj   +1 more source

Mitogenic effects of phosphatidylcholine nanoparticles on MCF-7 breast cancer cells [PDF]

, 2014
Lecithins, mainly composed of the phospholipids phosphatidylcholines (PC), have many different uses in the pharmaceutical and clinical field. PC are involved in structural and biological functions as membrane trafficking processes and cellular signaling.
Corradi, Gerardo Raul, Gándola, Yamila Belén, Irene, Pablo Ezequiel, Miquet, Johanna Gabriela, Pérez, Sebastián E., Sotelo, Ana Isabel   +5 more
core   +1 more source

Collision-induced dissociation of doubly-charged barium-cationized lipids generated from liquid samples by atmospheric pressure matrix-assisted laser desorption/ionization provides structurally diagnostic product ions [PDF]

, 2017
Obtaining structural information for lipids such as phosphatidylcholines, in particular the location of double bonds in their fatty acid constituents, is an ongoing challenge for mass spectrometry (MS) analysis.
Cramer, Rainer, Hale, Oliver J.
core   +1 more source