Results 21 to 30 of about 74,308 (377)

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2011
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
A Brandstätter, A Döring, A Köttgen, A Lorber, AA Hicks, Alexey Polonikov, AM Kim, Annette Peters, C Gieger, Christian Gieger, CM Rodrigues, CM Slupsky, CM Tingen, Cornelia Prehn, D Fairweather, Fabian J. Theis, Florian Kronenberg, G Paré, H Löwel, H-E Wichmann, Heinz Erich Wichmann, I Pe'er, J Krumsiek, J Nikkilä, J Yeboah, Jan Krumsiek, Janina S. Ried, Jerzy Adamski, JQ Purnell, Karsten Suhre, Kirstin Mittelstrass, LA Lange, M Steffens, Mark I. McCarthy, ML Summar, P Filzmoser, R Holle, R Paternoster, Rui Wang-Sattler, SE Geller, SE Reuter, Stephan Weidinger, T Illig, Thomas Illig, Thomas Meitinger, W Mostertz, Werner Roemisch-Margl, WL Holland, YS Aulchenko, Zhonghao Yu   +49 more
core   +6 more sources

Discovery of Infection Associated Metabolic Markers in Human African Trypanosomiasis [PDF]

, 2015
Peer reviewedPublisher ...
Alibu, Vincent Pius, Gomez-Romero, Maria, Holmes, Elaine, Lamour, Sabrina D, Saric, Jasmina, Sternberg, Jeremy M, Vorkas, Pangiotis A   +6 more
core   +11 more sources

Fasting increases 18:2-containing phosphatidylcholines to complement the decrease in 22:6-containing phosphatidylcholines in mouse skeletal muscle.

PLoS ONE, 2021
Fasting stimulates catabolic reactions in skeletal muscle to survive nutrient deprivation. Cellular phospholipids have large structural diversity due to various polar-heads and acyl-chains that affect many cellular functions. Skeletal muscle phospholipid
Nanami Senoo, Takumi Akahori, Hiyori Ichida, Noriyuki Miyoshi, Akihito Morita, Takao Shimizu, Hideo Shindou, Shinji Miura   +7 more
doaj   +1 more source

Elevated Free Phosphatidylcholine Levels in Cerebrospinal Fluid Distinguish Bacterial from Viral CNS Infections

Cells, 2021
The identification of CSF biomarkers for bacterial meningitis can potentially improve diagnosis and understanding of pathogenesis, and the differentiation from viral CNS infections is of particular clinical importance.
Amani Al-Mekhlafi, Kurt-Wolfram Sühs, Sven Schuchardt, Maike Kuhn, Kirsten Müller-Vahl, Corinna Trebst, Thomas Skripuletz, Frank Klawonn, Martin Stangel, Frank Pessler   +9 more
doaj   +1 more source

Hemolysis of Rat Erythrocytes by Replacement of the Natural Phosphatidylcholine by Various Phosphatidylcholines [PDF]

European Journal of Biochemistry, 1980
Vesicles of a variety of types of phosphatidylcholine have been shown to be suitable donors of phosphatidylcholine to intact rat erythrocytes in the presence of a specific phosphatidylcholine exchange protein. Coincident with the progression of phosphatidylcholine exchange is the onset of hemolysis, occurring at degrees of exchange characteristic for ...
Lange, L.G., van Meer, G., op den Kamp, J.A.F., van Deenen, L.L.M.   +3 more
openaire   +4 more sources

Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease [PDF]

, 1992
Because fatty acid composition of biliary phospholipids influences cholesterol secretion into bile, we investigated whether replacement of n-1 monounsaturated or n-6 polyunsaturated fatty acids with n-3 polyunsaturated fatty acids in biliary ...
Abell, Ahlberg, Balasubramaniam, Barlett, Bernd Seifferth, Berr, Berr, Berr, Berr, Carey, Carey, Carulli, Cohen, Cohen, Coleman, Dam, Delchier, Dieter Jüngst, Everson, Frieder Berr, Glenn, Goodnight, Gustav Paumgartner, Harris, Hofmann, Holan, Holzbach, Joseph Holl, Juniper, Kaludzny, Kelly, Kuroki, Leaf, Lee, Lippel, Lorenz, Magnuson, Marks, Nestel, Nestel, O'Leary, Parhofer, Paul, Phillipson, Pomeranz, Ramond, Robins, Robins, Sanders, Scobey, Sedaghat, Snedecor, Strasberg, Sven Fischer, Sömjen, Ventura, von Schacky, Wagner, Wechsler, Werner O. Richter   +59 more
core   +1 more source

The human plasma-metabolome: Reference values in 800 French healthy volunteers; impact of cholesterol, gender and age. [PDF]

PLoS ONE, 2017
Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim of this study was to define the "normal" metabolome in healthy volunteers. We included 800 French
Séverine Trabado, Abdallah Al-Salameh, Vincent Croixmarie, Perrine Masson, Emmanuelle Corruble, Bruno Fève, Romain Colle, Laurent Ripoll, Bernard Walther, Claire Boursier-Neyret, Erwan Werner, Laurent Becquemont, Philippe Chanson   +12 more
doaj   +1 more source

Phosphatidylcholine

Biophysical Journal, 1992
Two mono-cis-unsaturated phosphatidylcholine (PC) lipid molecules, having very different gel-liquid crystalline phase transition temperatures as a consequence of the relative positions of the double bond, exhibit PC:cholesterol phase diagrams that are very similar to each other and to that obtained previously for a fully saturated PC:cholesterol ...
Jenifer Thewalt, Myer Bloom
openaire   +3 more sources

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents. [PDF]

PLoS ONE, 2016
The synthesis of novel phosphatidylcholines with geranic and citronellic acids in sn-1 and sn-2 positions is described. The structured phospholipids were obtained in high yields (59-87%) and evaluated in vitro for their cytotoxic activity against several
Anna Gliszczyńska, Natalia Niezgoda, Witold Gładkowski, Marta Czarnecka, Marta Świtalska, Joanna Wietrzyk   +5 more
doaj   +1 more source