Results 31 to 40 of about 74,308 (377)

p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1

Cells, 2022
Altered lipid metabolism is a hallmark of cancer. p73, a p53 family member, regulates cellular processes and is expressed as multiple isoforms. However, the role of p73 in regulating lipid metabolism is not well-characterized.
Zachary Rabow, Kyra Laubach, Xiangmudong Kong, Tong Shen, Shakur Mohibi, Jin Zhang, Oliver Fiehn, Xinbin Chen   +7 more
doaj   +1 more source

Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease

Metabolites, 2022
(1) Background: This work aims to investigate the metabolomic changes in PIGinH11 pigs and investigate differential compounds as potential therapeutic targets for metabolic diseases.
Jianping Xu, Kaiyi Zhang, Bintao Qiu, Jieying Liu, Xiaoyu Liu, Shulin Yang, Xinhua Xiao   +6 more
doaj   +1 more source

Serum antibodies to phosphatidylcholine in MS [PDF]

Neurology Neuroimmunology & Neuroinflammation, 2020
To evaluate the value of serum immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies reactive with phosphatidylcholine (PC) and lactosylceramide (LC) as biomarkers in MS.We developed an ultrasensitive ELISA technique to analyze serum IgG and IgM antibodies to LC and PC, which we used to analyze samples from 362 patients with MS, 10 patients with
Maria Cruz Sádaba, Veit Rothhammer, Úrsula Muñoz, Cristina Sebal, Esther Escudero, Pia Kivisäkk, Maria Isabel Garcia Sanchez, Guillermo Izquierdo, Stephen L. Hauser, Sergio E. Baranzini, Jorge R. Oksenberg, Roberto Álvarez-Lafuente, Rohit Bakshi, Howard L. Weiner, Francisco J. Quintana   +14 more
openaire   +6 more sources

Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease [PDF]

, 2014
Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may reach epidemic proportions over the next decade. Efforts have been made to improve diagnosis and management of CKD.
Argilés, Àngel, Dakna, Mohammed, Delles, Christian, Duranton, Flore, Gayrard, Nathalie, Husi, Holger, Klein, Julie, Koeck, Thomas, Lundin, Ulrika, Mischak, Harald, Mullen, William, Nkuipou-Kenfack, Esther, Weinberger, Klaus M., Zürbig, Petra   +13 more
core   +9 more sources

Arsenic‐Containing Phosphatidylcholines: A New Group of Arsenolipids Discovered in Herring Caviar

Angewandte Chemie, 2016
A new group of arsenolipids based on cell‐membrane phosphatidylcholines has been discovered in herring caviar (fish roe). A combination of HPLC with elemental and molecular mass spectrometry was used to identify five arsenic‐containing ...
S. A. Viczek, K. B. Jensen, K. Francesconi   +2 more
semanticscholar   +2 more sources

Circulating Lysophosphatidylcholines, Phosphatidylcholines, Ceramides, and Sphingomyelins and Ovarian Cancer Risk: a 23-year Prospective Study

bioRxiv, 2019
Background Experimental evidence supports a role of lipid dysregulation in ovarian cancer progression and metastasis. We estimated associations with ovarian cancer risk for circulating levels of four lipid groups measured 3-23 years before diagnosis ...
O. Zeleznik, C. Clish, P. Kraft, Julian Avila-Pancheco, A. Eliassen, S. Tworoger   +5 more
semanticscholar   +1 more source

Functional role of water in membranes updated: A tribute to Träuble [PDF]

, 2015
The classical view of a cell membrane is as a hydrophobic slab in which only nonpolar solutes can dissolve and permeate. However, water-soluble non-electrolytes such as glycerol, erythritol, urea and others can permeate lipid membranes in the liquid ...
Bouchet, Ana María, Disalvo, Edgardo Anibal, Frías, María de los Ángeles, Hollmann, Axel, Martini, María Florencia, Pinto, Oscar Alejandro   +5 more
core   +1 more source

Separating and Profiling Phosphatidylcholines and Triglycerides from Single Cellular Lipid Droplet by In-Tip Solvent Microextraction Mass Spectrometry.

Analytical Chemistry, 2019
The analysis of lipid droplets (LDs) by mass spectrometry at the single LD level is still an analytical challenge. In this work, we developed a novel technique termed in-tip solvent microextraction mass spectrometry for the separation and profiling of ...
Yaoyao Zhao, Zhen Chen, Yue Wu, Takayuki Tsukui, Xiaoxiao Ma, Xinrong Zhang, H. Chiba, S. Hui   +7 more
semanticscholar   +1 more source

Expansion of Phosphatidylcholine and Phosphatidylserine/Phosphatidylcholine Monolayers by Differently Charged Amphiphiles [PDF]

Zeitschrift für Naturforschung C, 2001
Abstract Monolayer Technique, Nonionic Detergent, Erythrocyte Shape The degree and time-course of expansion of palmitoyloleoylphosphatidylcholine (PC) and bovine brain phosphatidylserine (PS)/PC (75:25, mol/mol) monolayers at 32 mN/m caused by differently charged amphiphiles (detergents) added to the sub-phase buffer (pH 7.4, 22 °C ...
K Bialkowska, Henry Hägerstrand, Malgorzata Bobrowska-Hägerstrand   +2 more
openaire   +2 more sources

Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. [PDF]

, 2016
ObjectiveTo determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis
Boyle, David, Guma, Monica, Kavanaugh, Arthur, Lodi, Alessia, Sweeney, Shannon R, Tiziani, Stefano, Wang, Bo   +6 more
core   +2 more sources