Results 41 to 50 of about 31,592 (359)

Miscibility of Phosphatidylcholines in Bilayers: Effect of Acyl Chain Unsaturation

Membranes, 2023
The miscibility of phospholipids in a hydrated bilayer is an issue of fundamental importance for understanding the organization of biological membranes. Despite research on lipid miscibility, its molecular basis remains poorly understood.
Agata Żak, Natan Rajtar, Waldemar Kulig, Mariusz Kepczynski   +3 more
doaj   +1 more source

Sets of coregulated serum lipids are associated with Alzheimer's disease pathophysiology [PDF]

, 2019
Introduction: Comorbidity with metabolic diseases indicates that lipid metabolism plays a role in the etiology of Alzheimer's disease (AD). Comprehensive lipidomic analysis can provide new insights into the altered lipid metabolism in AD.
Arnold, Matthias, Baillie, Rebecca, Barupal, Dinesh Kumar, Consortium, Alzheimer Disease Metabolomics, Fan, Sili, Fiehn, Oliver, Initiative, Alzheimer's Disease Neuroimaging, Kaddurah‐Daouk, Rima, Meikle, Peter J, Nho, Kwangsik, Saykin, Andrew J   +10 more
core   +2 more sources

Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review

Frontiers in Medicine
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c ...
Liang Wu, Sheng-Cai Zhu, Yang He, Yun-Xia Zhu, Xiao-Liang Ou-Yang, Deng Zhang, Chun-Ming Li   +6 more
doaj   +1 more source

Design and applications of a fluorescent labeling technique for lipid and surfactant preformed vesicles [PDF]

ACS Omega 4, 10485-10493 (2019), 2019
Amphiphilic molecules such as surfactants, lipids and block copolymers can be assembled into bilayers and form vesicles. Fluorescent membrane labeling methods require the use of dye molecules that can be inserted in the bilayers at different stages of the synthesis. To our knowledge there is no generalized method for labeling preformed vesicles. Herein
arxiv   +1 more source

Anti-inflammatory Effects of Phosphatidylcholine [PDF]

Journal of Biological Chemistry, 2007
We recently showed that mucus from patients with ulcerative colitis, a chronic inflammatory disorder of the colon, is characterized by a low level of phosphatidylcholine (PC) while clinical studies reveal that therapeutic addition of PC using slow release preparations is beneficial. The positive role of PC in this disease is still elusive.
Treede, Irina, Braun, Annika, Sparla, Richard, Kuehnel, Mark, Giese, Thomas, Turner, Jerrold R., Anes, Elsa, Kulaksiz, Hasan, Fuellekrug, Joachim, Stremmel, Wolfgang, Griffiths, Gareth, Ehehalt, Robert   +11 more
openaire   +4 more sources

Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques

Nature Communications, 2021
Oxidized phosphatidylcholines (oxPCs) are a structurally diverse class of lipids associated with various diseases. Here, the authors use mass spectrometry to construct a spectral library of 465 oxPCs and subsequently profile oxPCs formed during ...
Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada   +8 more
doaj   +1 more source

Sterols sense swelling in lipid bilayers [PDF]

, 1998
In the mimetic membrane system of phosphatidylcholine bilayers, thickening (pre-critical behavior, anomalous swelling) of the bilayers is observed, in the vicinity of the main transition, which is non-linear with temperature. The sterols cholesterol and androsten are used as sensors in a time-resolved simultaneous small- and wide angle x-ray ...
arxiv   +1 more source

Editorial overview: recent innovations in the metabolomics revolution [PDF]

, 2017
No abstract ...
Kamphorst, Jurre J., Lewis, Ian A.
core   +1 more source

Functional, transcriptomic, and lipidomic studies of the choC gene encoding a phospholipid methyltransferase in Aspergillus fumigatus

Microbiology Spectrum
Phosphatidylcholines (PCs) are a class of cell membrane phospholipids playing important roles in cellular integrity and signaling. In eukaryotes, PCs are biosynthesized via the Kennedy cytidine nucleotide and the Bremer-Greenberg pathways.
Jiao Pan, Xinyu Yang, Cuiting Hu, Tongtong Fu, Xiuyan Zhang, Zijun Liu, Yu Wang, Fengyu Zhang, Xiaoyuan He, Jae-Hyuk Yu   +9 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source