Results 41 to 50 of about 74,308 (377)

Structural Characterization of Phosphatidylcholines Using 193 nm Ultraviolet Photodissociation Mass Spectrometry.

Analytical Chemistry, 2017
Advances in mass spectrometry have made it a preferred tool for structural characterization of glycerophospholipids. Collisional activation methods commonly implemented on commercial instruments do not provide fragmentation patterns that allow ...
Dustin R. Klein, J. Brodbelt
semanticscholar   +1 more source

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles [PDF]

, 2013
Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest
Adamski, J. (Jerzy), Aulchenko, Y.S. (Yurii), Axenovich, T.I. (Tatiana), Biloglav, Z. (Zrinka), Broer, L. (Linda), Campbell, H. (Harry), Campbell, S. (Susan), Demirkan, A. (Ayşe), Dharuri, H. (Harish), Domingues, I. (Inês), Duijn, C.M. (Cornelia) van, Floyd, J. (Jamie), Franke, L. (Lude), Franklin, C.S. (Christopher), Gieger, C. (Christian), Gnewuch, C. (Carsten), Gyllensten, U. (Ulf), Hastie, N. (Nick), Hayward, C. (Caroline), Henneman, P. (Peter), Hettne, K.M. (Kristina), Hicks, A.A. (Andrew), Hoen, P.A.C. (Peter) 't, Hofman, A. (Albert), Huffman, J.E. (Jennifer), Igl, W. (Wilmar), Isaacs, A.J. (Aaron), Jansen, R.C. (Ritsert), Janssens, A.C.J.W. (Cécile), Johansson, A. (Åsa), Jonasson, I. (Inger), Karssen, L.C. (Lennart), Kirichenko, A.V. (Anatoly), Klinken, J.B. (Jan) van, Kolcic, I. (Ivana), Liebisch, G. (Gerhard), Meitinger, T. (Thomas), Mook-Kanamori, D.O. (Dennis), Oostra, B.A. (Ben), Pattaro, C. (Cristian), Pfeufer, A. (Arne), Pichler, I. (Irene), Polasek, O. (Ozren), Pramstaller, P.P. (Peter Paul), Rivadeneira Ramirez, F. (Fernando), Roos, M. (Marco), Rudan, I. (Igor), Schmitz, G. (Gerd), Struchalin, M.V. (Maksim), Suhre, K. (Karsten), Ugocsai, P. (Peter), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Wang-Sattler, R. (Rui), Wild, S.H. (Sarah), Willems van Dijk, J.A.P. (Ko), Wilson, J.F. (James F), Witteman, J.C.M. (Jacqueline), Wright, A.F. (Alan), Zaboli, G. (Ghazal), Zorkoltseva, I.V. (Irina)   +60 more
core   +1 more source

Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]

, 2006
Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
core   +1 more source

Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis.

Rheumatology, 2016
OBJECTIVE To identify novel biomarker(s) for predicting advanced knee OA. METHODS Study participants were derived from the Newfoundland Osteoarthritis Study and the Tasmania Older Adult Cohort Study.
Weidong Zhang, G. Sun, D. Aitken, S. Likhodii, Ming Liu, G. Martin, A. Furey, E. Randell, P. Rahman, G. Jones, G. Zhai   +10 more
semanticscholar   +1 more source

Oxidized phosphatidylcholines are produced in renal ischemia reperfusion injury. [PDF]

PLoS ONE, 2018
The aim of this study was to determine the individual oxidized phosphatidylcholine (OxPC) molecules generated during renal ischemia/ reperfusion (I/R) injury.Kidney ischemia was induced in male Sprague-Dawley rats by clamping the left renal pedicle for ...
Zahra Solati, Andrea L Edel, Yue Shang, Karmin O, Amir Ravandi   +4 more
doaj   +1 more source

Effects of diacylglycerols on conformation of phosphatidylcholine headgroups in phosphatidylcholine/phosphatidylserine bilayers

Biophysical Journal, 1995
The effects of five diacylglycerols (DAGs), diolein, 1-stearoyl,2-arachidonoyl-sn-glycerol, dioctanoylglycerol, 1-oleoyl,2-sn-acetylglycerol, and dipalmitin (DP), on the structure of lipid bilayers composed of mixtures of phosphatidylcholine and phosphatidylserine (4:1 mol/mol) were examined by 2H nuclear magnetic resonance (NMR ...
Dan Borchardt, D.S. Lester, Raphael Zidovetzki, Edward M. Goldberg   +3 more
openaire   +2 more sources

Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer’s Disease

Journal of Alzheimer's Disease, 2016
Lipids such as ceramides and phosphatidylcholines (PC) have been found altered in the plasma of Alzheimer’s disease (AD) patients in a number of discovery studies. For this reason, the levels of 6 ceramides and 3 PCs, with different fatty acid length and
Min Kim, A. Nevado-Holgado, Luke Whiley, S. Snowden, H. Soininen, I. Kloszewska, P. Mecocci, M. Tsolaki, B. Vellas, M. Thambisetty, R. Dobson, J. Powell, Michelle K. Lupton, A. Simmons, L. Velayudhan, S. Lovestone, P. Proitsi, C. Legido-Quigley   +17 more
semanticscholar   +1 more source

a targeted metabolomic approach in two German prospective cohorts [PDF]

, 2018
Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people.
Adamski, Jerzy, Boeing, Heiner, Floegel, Anna, Illig, Thomas, Johnson, Theron, Kaaks, Rudolf, Kühn, Tilman, Otto, Wolfgang, Pischon, Tobias, Prehn, Cornelia, Rolle-Kampczyk, Ulrike, Sookthai, Disorn, von Bergen, Martin, Weikert, Cornelia   +13 more
core   +1 more source

Current perspectives for metabolomics and lipidomics in dyslipidemia of acne vulgaris: a mini review

Frontiers in Medicine
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit. Many studies have reported that people with AV have higher levels of total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-c ...
Liang Wu, Sheng-Cai Zhu, Yang He, Yun-Xia Zhu, Xiao-Liang Ou-Yang, Deng Zhang, Chun-Ming Li   +6 more
doaj   +1 more source

Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC.

PLoS ONE, 2015
ObjectiveAlthough metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations.
Marion Carayol, Idlir Licaj, David Achaintre, Carlotta Sacerdote, Paolo Vineis, Timothy J Key, N Charlotte Onland Moret, Augustin Scalbert, Sabina Rinaldi, Pietro Ferrari   +9 more
doaj   +1 more source