Results 61 to 70 of about 17,880 (307)

Exploratory analysis of epilepsy biomarkers using untargeted metabolomics across multiple cohorts

Frontiers in Neurology
IntroductionEpilepsy is a common central nervous system disorder characterized by abnormal brain electrical activity. Diagnosing epilepsy can be challenging, as it has various causes and different clinical manifestations.
Kaisa T. Oja, Kaisa T. Oja, Mihkel Ilisson, Mihkel Ilisson, Karit Reinson, Karit Reinson, Kai Muru, Kai Muru, Tiia Reimand, Tiia Reimand, Hedi Peterson, Dmytro Fishman, Dmytro Fishman, Toomas Haller, Jaanika Kronberg, Estonian Biobank Research Team, Monica H. Wojcik, Monica H. Wojcik, Monica H. Wojcik, Adam D. Kennedy, Laura Sommerville, Gregory Michelotti, Anne O’Donnell-Luria, Anne O’Donnell-Luria, Eve Õiglane-Shlik, Eve Õiglane-Shlik, Sander Pajusalu, Sander Pajusalu, Katrin Õunap, Katrin Õunap   +29 more
doaj   +1 more source

Viscosity of phosphatidylcholine (lecithin)

Journal of Pharmacy and Pharmacology, 1966
AbstractThe viscosities of egg lecithin dispersed in water have been measured by means of a Couette viscometer. The more concentrated dispersions are thixotropic, but below 1·8% w/w of lecithin the sols become Newtonian. From the extrapolated ratio of specific viscosity to volume fraction, the dispersed particles are considered to be of an elongated ...
J H, Perrin, L, Saunders
openaire   +2 more sources

Concentrations of lysophosphatidylcholines, phosphatidylcholines and sphingomyelins in the serum of cows differing in the degree of lipolysis and parity.

, 2016
Concentrations of lysophosphatidylcholines, phosphatidylcholines and sphingomyelins in the serum of cows differing in the degree of lipolysis and parity.
Elke Humer (3157965), Annabella Khol-Parisini (3157962), Qendrim Zebeli (494578), Barbara U. Metzler-Zebeli (486998), Leonhard Gruber (3157968)   +4 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Models including plasma levels of sphingomyelins and phosphatidylcholines as diagnostic and prognostic biomarkers of endometrial cancer.

, 2018
In endometrial cancer, biomarkers for preoperative identification of patients with low risk for disease progression would enable stratification according to the extent of surgery needed, and would avoid the complications that can be associated with ...
Prehn, C., Cornelia Prehn, Adamski, J., Tamara Knific, Jerzy Adamski, Rižner, T.L., Katja Vouk, Smrkolj,, Tea Lanišnik Rižner, Špela Smrkolj, Vouk, K., Knific, T.   +11 more
core   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Impaired response of biliary lipid secretion to a lithogenic diet in phosphatidylcholine transfer protein-deficient mice

Journal of Lipid Research, 2005
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic lipid transfer protein that is highly expressed in liver and catalyzes intermembrane transfer of phosphatidylcholines in vitro.
Michele K. Wu, Hideyuki Hyogo, Suresh K. Yadav, Phyllis M. Novikoff, David E. Cohen   +4 more
doaj   +1 more source

Phospholipid Species in Newborn and 4 Month Old Infants after Consumption of Different Formulas or Breast Milk. [PDF]

PLoS ONE, 2016
INTRODUCTION:Arachidonic acid (AA) and docosahexaenoic acid (DHA) are important long-chain polyunsaturated fatty acids for neuronal and cognitive development and are ingredients of infant formulae that are recommended but there is no evidence based ...
Olaf Uhl, Manja Fleddermann, Christian Hellmuth, Hans Demmelmair, Berthold Koletzko   +4 more
doaj   +1 more source

Biosynthesis of Sciadonic Acid Derived from Gymnosperms with Anti‐Colitis Activity

Advanced Science, EarlyView.
This study establishes an efficient Yarrowia lipolytica platform for unusual sciadonic acid (SCA) production and assess the anti‐colitis efficacy in mice of SCA, supporting its potential as a novel therapeutic lipid. ABSTRACT Sciadonic acid (SCA), Δ5‐unsaturated fatty acid with anti‐inflammatory and lipid‐regulatory properties, is predominantly derived
Yadi Gao, Wei Liu, Xiuping Liang, Jie Bai, Hong Chang, Wenchao Chen, Mohamed A. Farag, Jianbo Xiao, Huifeng Jiang, Jiasheng Wu, Lili Song   +10 more
wiley   +1 more source