Results 71 to 80 of about 17,880 (307)

Serum metabolite profiling reveals metabolic characteristics of sepsis patients using LC/MS-based metabolic profiles: a cross-sectional study

BMC Medical Genomics, 2023
Background Individuals with sepsis exhibited a higher likelihood of benefiting from early initiation of specialized treatment to enhance the prognosis of the condition. The objective of this study is to identify potential biomarkers of sepsis by means of
Jinliang Peng, Chongrong Qiu, Jun Zhang, Xiaoliu Xiao   +3 more
doaj   +1 more source

MS/MS and IMS identifications and distributions of phosphatidylcholines (PCs) in three groups of seminiferous tubules (STs).

, 2015
a--, not detected.MS/MS and IMS identifications and distributions of phosphatidylcholines (PCs) in three groups of seminiferous tubules (STs).
Piyachat Chansela (177596), Jaruwan Poljaroen (703529), Tanapan Siangcham (703528), Noritaka Masaki (300398), Takahiro Hayasaka (119887), Morakot Sroyraya (177604), Peter J. Hanna (679586), Mitsutoshi Setou (119915), Attakorn Engsusophon (177610), Prasert Sobhon (177629), Saowaros Suwansa-ard (703530)   +10 more
core   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

Expansion of Phosphatidylcholine and Phosphatidylserine/Phosphatidylcholine Monolayers by Differently Charged Amphiphiles

Zeitschrift für Naturforschung C, 2001
Abstract Monolayer Technique, Nonionic Detergent, Erythrocyte Shape The degree and time-course of expansion of palmitoyloleoylphosphatidylcholine (PC) and bovine brain phosphatidylserine (PS)/PC (75:25, mol/mol) monolayers at 32 mN/m caused by differently charged amphiphiles (detergents) added to the sub-phase buffer (pH 7.4, 22 °C ...
K, Białkowska, M, Bobrowska-Hägerstrand, H, Hägerstrand   +2 more
openaire   +2 more sources

Studies of the thermotropic phase behavior of phosphatidylcholines containing 2-alkyl substituted fatty acyl chains: a new class of phosphatidylcholines forming inverted nonlamellar phases

, 1994
We have synthesized a number of 1,2-diacyl phosphatidylcholines with hydrophobic substituents adjacent to the carbonyl group of the fatty acyl chain and studied their thermotropic phase behavior by differential scanning calorimetry, 31P-nuclear magnetic ...
Gruner, S.M., Harper, P.E., Turner, D.C., Lewis, R.N., McElhaney, R.N.   +4 more
core   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie, EarlyView.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +2 more sources

Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry

Scientific Reports, 2017
Direct mass spectrometry analysis of metabolic effects of clenbuterol and salbutamol on pork quality at the molecular level is incredibly beneficial for food regulations, public health and the development of new anti-obesity drugs.
Haiyan Lu, Hua Zhang, Tenggao Zhu, Yipo Xiao, Shaoxian Xie, Haiwei Gu, Meng Cui, Liping Luo   +7 more
doaj   +1 more source

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication[S]

Journal of Lipid Research, 2014
Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is lacking.
Lukas Bahati Tanner, Charmaine Chng, Xue Li Guan, Zhengdeng Lei, Steven G. Rozen, Markus R. Wenk   +5 more
doaj   +1 more source

Preferable stimulation of PON1 arylesterase activity by phosphatidylcholines with unsaturated acyl chains or oxidized acyl chains at sn-2 position

, 2006
To examine the effect of phospholipids on PON1 activities, purified PON1 was exposed to phospholipids prior to the determination of arylesterase and paraoxonase activities. Phosphatidylcholines with saturated acyl chains (C10–C16) showed a stimulation of
Sok, Dai-Eun, Nguyen, Su Duy
core   +1 more source