Results 61 to 70 of about 31,592 (359)

Deletion of TSPO resulted in change of metabolomic profile in retinal pigment epithelial cells [PDF]

, 2019
Age-related macular degeneration is the main cause of vision loss in the aged population worldwide. Drusen, extracellular lesions formed underneath the retinal pigment epithelial (RPE) cells, are a clinical feature of AMD and associated with AMD ...
Abdulwahab Alamri, David Watson, Farooqui, Lincoln Biswas, Rohrer, Suzuki, Winkler, Xinhua Shu   +7 more
core   +2 more sources

Phosphatidylcholine synthesis in yeast.

Journal of Lipid Research, 1988
The two pathways for the biosynthesis of phosphatidylcholine, by way of phosphocholine and by methylation of phosphatidylethanolamine, in wild-type yeast (Saccharomyces cerevisiae) and in the yeast mutant GL7 have been compared. The mutant requires for growth a sterol, unsaturated fatty acids, and methionine.
Konrad Bloch, J Chin
openaire   +3 more sources

Transmembrane Activation of Catalysis and Protein Refolding in Synthetic Cells by Enzymes and Nanozymes

Advanced Functional Materials, EarlyView.
Synthetic cells are engineered herein to respond to an external chemical messenger by the activation of intracellular catalysis. The chemical messenger molecules are catalytically generated by an extracellular enzyme or a mineral surface, whereas the intracellular catalysis emerges via direct enzyme activation or via protein refolding.
Dante G. Andersen, Andreas B. Pedersen, Mireia Casanovas Montasell, Søren Moesgaard, Anja Bille Bohn, Alexander N. Zelikin   +5 more
wiley   +1 more source

Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes. [PDF]

Cardiovasc Diabetol
Background Disruption of lipid metabolism contributes to increased cardiovascular risk in diabetes. Methods We evaluated the associations between serum lipidomic profile and subclinical carotid atherosclerosis (SCA) in type 1 (T1D) and type 2 (T2D ...
Barranco-Altirriba M, Rossell J, Alonso N, Weber RJM, Ortega E, Lloyd GR, Hernandez M, Yanes O, Capellades J, Winder C, Junza A, Falguera M, Franch-Nadal J, Dunn WB, Perera-Lluna A, Castelblanco E, Mauricio D.   +16 more
europepmc   +2 more sources

Genetic causality of lipidomic and immune cell profiles in ischemic stroke. [PDF]

Front Neurol
BackgroundIschemic stroke (IS) is a global health issue linked to lipid metabolism and immune cell responses. This study uses Mendelian randomization (MR) to identify genetic risk factors for IS subtypes using comprehensive genetic data from lipidomic ...
Chen H, Zheng Z, Cai X, Li S, Chen M, Wu J, He W, Gao F.   +7 more
europepmc   +2 more sources

Viscosity of phosphatidylcholine (lecithin)

Journal of Pharmacy and Pharmacology, 1966
Abstract The viscosities of egg lecithin dispersed in water have been measured by means of a Couette viscometer. The more concentrated dispersions are thixotropic, but below 1·8% w/w of lecithin the sols become Newtonian. From the extrapolated ratio of specific viscosity to volume fraction, the dispersed particles are considered to be of
J. Perrin, L. Saunders
openaire   +3 more sources

Advent of Novel Phosphatidylcholine-Associated Nonsteroidal Anti-Inflammatory Drugs with Improved Gastrointestinal Safety

Gut and Liver, 2013
The mucosa of the gastrointestinal (GI) tract exhibits hydrophobic, nonwettable properties that protect the underlying epithelium from gastric acid and other luminal toxins.
doaj   +1 more source

Serum metabolite profiling reveals metabolic characteristics of sepsis patients using LC/MS-based metabolic profiles: a cross-sectional study

BMC Medical Genomics, 2023
Background Individuals with sepsis exhibited a higher likelihood of benefiting from early initiation of specialized treatment to enhance the prognosis of the condition. The objective of this study is to identify potential biomarkers of sepsis by means of
Jinliang Peng, Chongrong Qiu, Jun Zhang, Xiaoliu Xiao   +3 more
doaj   +1 more source

Ripple-like instability in the simulated gel phase of finite size phosphocholine bilayers [PDF]

arXiv, 2021
Atomistic molecular dynamics simulations have reached a degree of maturity that makes it possible to investigate the lipid polymorphism of model bilayers over a wide range of temperatures. However if both the fluid $L_{\alpha}$ and tilted gel $L_{\beta'}$ states are routinely obtained, the $P_{\beta'}$ ripple phase of phosphatidylcholine lipid bilayers
arxiv  

Systematic Comparison of Commercial Uranyl‐Alternative Stains for Negative‐ and Positive‐Staining Transmission Electron Microscopy of Organic Specimens

Advanced Healthcare Materials, EarlyView.
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling, Stephanie Eitner, Davide Bottone, Gea Cereghetti, Peter Wick   +4 more
wiley   +1 more source