Results 61 to 70 of about 10,346 (145)

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

open access: yesNature Communications, 2018
Methyl metabolites in the one-carbon cycle, such as phosphatidylcholines and S-adenosylmethionine, play a role in hepatic triglyceride regulation. Here Kim et al.
Young-Chae Kim   +9 more
doaj   +1 more source

Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study.

open access: yesPLoS ONE
There is a phenotype of obese individuals termed metabolically healthy obese that present a reduced cardiometabolic risk. This phenotype offers a valuable model for investigating the mechanisms connecting obesity and metabolic alterations such as Type 2 ...
Laia Bertran   +5 more
doaj   +1 more source

Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation

open access: yesGenome Medicine
Background Altered metabolism plays a role in the pathophysiology of cardiac diseases, such as atrial fibrillation (AF) and heart failure (HF). We aimed to identify novel plasma metabolites and proteins associating with cardiac disease. Methods Mendelian
Marion van Vugt   +7 more
doaj   +1 more source

Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)Research in context

open access: yesEBioMedicine
Summary: Background: Altered lipid metabolism is a hallmark of cancer development. However, the role of specific lipid metabolites in colorectal cancer development is uncertain.
Rhea Harewood   +38 more
doaj   +1 more source

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