Results 221 to 230 of about 72,154 (294)
Lipids regulate epidermal growth factor receptor activation by its ligands. [PDF]
Hutchison JM, Lemmon MA.
europepmc +1 more source
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Causal Association of Plasma Lipidome With Inflammatory Bowel Diseases and Mediating Role of Circulating Inflammatory Proteins: A Mendelian Randomization Study. [PDF]
Yin L, Zhu Y, Kong F, Tu H, Zhang B.
europepmc +1 more source
The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang +3 more
wiley +1 more source
Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High-Fat Diet. [PDF]
Kranenburg E +8 more
europepmc +1 more source
Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers
Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis +7 more
wiley +1 more source

