Decoding Akkermansia muciniphila Effector Biology: From Microbial Molecules to Host Outcomes
Schematic overview of the proposed gut–brain axis mechanisms linking Akkermansia muciniphila to host outcomes. A. muciniphila‐derived signals, including SCFAs and P9/GLP‐1‐related endocrine pathways, may influence epithelial barrier integrity, inflammatory responses, systemic immune signaling, and neural communication through the enteric nervous system,
Amir Arsalan Ghahari +9 more
wiley +1 more source
Mendelian randomization analysis of lipidomic profiles and thyroid cancer risk in European populations. [PDF]
Li S, Yu H, Zhang D, Li Y.
europepmc +1 more source
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji +9 more
wiley +1 more source
<i>P. falciparum</i> PEBP protein is dispensable during asexual and sexual stages of development. [PDF]
Chakraborty B +3 more
europepmc +1 more source
Mitochondrial membrane remodeling in stress adaptation: Lipid control of organelle quality
Abstract Mitochondria respond to proteotoxic stress through the mitochondrial unfolded protein response, traditionally viewed as a transcriptional program that restores proteostasis by inducing chaperones and proteases. Emerging evidence indicates that mitochondrial membrane remodeling constitutes an additional adaptive component of this response ...
Lena J. Reichert +2 more
wiley +1 more source
Lipid Profiles and Fatty Acid Positional Distribution in Two Farmed Seahorse Species by Untargeted Lipidomics and Enzymatic Hydrolysis. [PDF]
Bi T +9 more
europepmc +1 more source
We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre +18 more
wiley +1 more source
Human milk phospholipids across lactation stages and their associations with infant neurodevelopment: a prospective cohort study in China. [PDF]
Yang S +12 more
europepmc +1 more source
C‐Terminal Nucleobase Modification Amplifies Peptide‐Mediated Liposome Fusion
Let's come together right now. Cationic peptides are known to promote aggregation of negatively charged liposomes through electrostatic interaction. The process is reversible: once neutrality is achieved, liposomes disaggregate. Here, we demonstrate that end‐capping peptides with nucleobases turns the process into irreversible fusion.
Laura Morbiato +4 more
wiley +1 more source

