Results 181 to 190 of about 82,133 (342)

Lipid Dynamics in the Amyloid Cascade Hypothesis: Evaluating the Biological Relevance of In Vitro Models

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
This review reconsiders the amyloid cascade by placing lipid dynamics at its core. It shows that free lipids, governed by critical micellar concentration, act as pathological chaperones that redirect amyloid aggregation toward membrane‐damaging species.
Sofia Serravalle   +6 more
wiley   +1 more source

Bioconjugation Strategies for Revealing the Roles of Glycerophospholipids in Cells

open access: yesChemBioChem, Volume 27, Issue 11, 15 June 2026.
Glycerophospholipids are the main class of phospholipids, essential for membrane structure, compartmentalization, and cellular signaling. To study their roles, innovative probes and advanced bioconjugation strategies have been developed, including by de novo lipid synthesis and bioorthogonal conjugation chemistry.
Brice Beauvais   +5 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids. [PDF]

open access: yesEmerg Microbes Infect
Yoo JE   +9 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

open access: yesAdvanced Science, Volume 13, Issue 32, 9 June 2026.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang   +7 more
wiley   +1 more source

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