Results 181 to 190 of about 85,741 (244)

Plasma Metabolomic Alterations Are Associated with T-Cell Senescence, Cytokine Dysregulation, and Prognosis in Elderly COVID-19 Patients. [PDF]

Biomedicines
Shang Y, Zhang H, Lang Y, Hu T, Chang C, Zhang L.   +5 more
europepmc   +1 more source

Functional Characterization and Application of Yarrowia lipolytica YlYxc1 for Enhanced Production of Sphingoid Bases

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
YlYxc1, an ER‐associated alkaline ceramidase of Yarrowia lipolytica, has the hydrolytic activity of ceramides, which can be exploited as a metabolic engineering target to enhance long‐chain base production. ABSTRACT Long‐chain bases (LCBs; sphingoid bases), derived from ceramide metabolism, are valuable sphingolipid intermediates for industrial ...
Seo Hyeon Shin, Eun Joo Jeon, Hye Yun Moon, Ga Yeong Go, Young Seo Yoo, Jae Kyeong Lee, Che Ok Jeon, Hyun Ah Kang   +7 more
wiley   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N-methyltransferases. [PDF]

FEBS J
Shevyreva I, Fritsch LS, Koch LM, Effing A, Aktas M, Narberhaus F.   +5 more
europepmc   +1 more source

Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT Fatty acid oxidation (FAO) is a metabolic vulnerability in cancer cells, making pharmacologic FAO inhibition a promising therapeutic strategy. This Phase I, open‐label, 3 + 3 dose‐escalation study evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of two oral FAO inhibitors—omeprazole (KN510), a carnitine ...
Wonyoung Choi, Jung W. Chun, Sung H. Sim, Sung‐Sik Han, Woo J. Lee, Joon H. Kang, Hyun Chul Kim, SeungHwan Lee, Jun H. Lee, Hyun J. Yoo, Soo‐Youl Kim, Sang M. Woo   +11 more
wiley   +1 more source

<i>Planococcus terreus</i> sp. nov. and <i>Planococcus flavus</i> sp. nov., Two New Species Isolated from Soil of the Napahai Plateau Wetland. [PDF]

Microorganisms
Lu W, Qian X, Zhang Z, Li Z, Yu Z, Tian Y, Li L, Wang Y.   +7 more
europepmc   +1 more source

Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10670-10682, November 2026.
ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk, Tina Okdahl, Marietta Kokla, Tommi Suvitaival, Gurjeet Kaur, Ismo M. Mattila, Simon M. Kienle, Christian Buhl, Knud Yderstræde, Troels S. Jensen, Peter Rossing, Flemming Pociot, Birgitte Brock, Cristina Legido‐Quigley, Páll Karlsson, Christian S. Hansen, Christina Brock, Joachim Størling, Karolina Sulek   +18 more
wiley   +1 more source

GFAP mutants cause imbalance of selective lipid classes in a cellular model of Alexander disease. [PDF]

iScience
Fernàndez-Bernal A, Goya-Iglesias N, Company-Marin I, Mota-Martorell N, Pekna M, Pekny M, Sol J, Obis È, Pamplona R, Pajares MA, Pérez-Sala D, Jové M.   +11 more
europepmc   +1 more source

Cargo Stability of Extracellular Vesicles Derived From Non‐Diseased Sources: Effects of Storage and Handling Conditions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale, membrane‐enclosed particles that transfer proteins, nucleic acids, lipids, and other bioactive molecules between cells. Their cargo‐bearing capacity supports applications in drug delivery, regenerative medicine, and biomarker development, but ex vivo handling can alter vesicle recovery and cargo ...
Khadijeh Abbasi, Mina Mohammadinasr, Roza Motavalli, Narges Arianfar, Attabak Toofani‐Milani, Moein Shirzad, Vahid Hosseini, Masoud Darabi   +7 more
wiley   +1 more source

Induction of Methuosis in Breast Cancer Stem Cells by a Cobalt(III) Complex Evokes Immunotherapeutic Response

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang, Sijie Wen, Xiao Feng, Hao Ren, Kuldip Singh, Haihua Xiao, Lingpu Zhang, Kogularamanan Suntharalingam   +7 more
wiley   +2 more sources

<i>Pseudomonas gilva</i> sp. nov., a Plant-Associated Bacterial Species with Growth-Promoting Traits and Partial Suppression of Peanut Southern Blight. [PDF]

Microorganisms
Ma T, Liu H, Zhao W, Du C, Chen Y, Liu J, Zheng Y, Wang Y, Xu R, Zhang X.   +9 more
europepmc   +1 more source