Phosphatidylserine Decarboxylase Downregulation in Uric Acid‑Induced Hepatic Mitochondrial Dysfunction and Apoptosis [PDF]
MedComm, 2023 The molecular mechanisms underlying uric acid (UA)‐induced mitochondrial dysfunction and apoptosis have not yet been elucidated. Herein, we investigated underlying mechanisms of UA in the development of mitochondrial dysfunction and apoptosis.
Youzhi Xu
exaly +4 more sources
Dual Regulation of Phosphatidylserine Decarboxylase Expression by Envelope Stress Responses [PDF]
Frontiers in Molecular Biosciences, 2021 Bacteria adapt to versatile environments by modulating gene expression through a set of stress response regulators, alternative Sigma factors, or two-component systems.
Yasmine Hassoun +4 more
doaj +6 more sources
Conditional targeting of phosphatidylserine decarboxylase to lipid droplets [PDF]
Biology Open, 2021 Phosphatidylethanolamine is an abundant component of most cellular membranes whose physical and chemical properties modulate multiple aspects of organelle membrane dynamics. An evolutionarily ancient mechanism for producing phosphatidylethanolamine is to
Santosh Kumar +4 more
doaj +6 more sources
Phosphatidylserine Decarboxylase Promotes Ferroptosis Through STAT3/GPX4 Signaling in Gastric Cancer [PDF]
Current Issues in Molecular BiologyGastric cancer (GC) remains a major global health burden, and increasing evidence suggests that ferroptosis plays an important role in regulating tumor cell survival.
Wenjie Lu, Youzhi Xu, Wanbao Zheng
exaly +4 more sources
Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 In the yeast, Saccharomyces cerevisiae, the synthesis of the essential phospholipid phosphatidylethanolamine (PE) is accomplished by a network of reactions which comprises four different pathways.
Martina Gsell +5 more
doaj +3 more sources
Suppression of respiratory growth defect of mitochondrial phosphatidylserine decarboxylase deficient mutant by overproduction of Sfh1, a Sec14 homolog, in yeast. [PDF]
PLoS ONE, 2019 Interorganelle phospholipid transfer is critical for eukaryotic membrane biogenesis. In the yeast Saccharomyces cerevisiae, phosphatidylserine (PS) synthesized by PS synthase, Pss1, in the endoplasmic reticulum (ER) is decarboxylated to ...
Aya Mizuike +5 more
doaj +3 more sources
Phosphatidylserine decarboxylase is critical for the maintenance of skeletal muscle mitochondrial integrity and muscle mass [PDF]
Molecular Metabolism, 2019 Objective: Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in the ...
Ahrathy Selathurai +13 more
doaj +2 more sources
Phosphatidylserine Decarboxylase Regulates Retinal Ganglion Cell Neurite Outgrowth with Altered Somal Membrane Fluidics and Mitochondrial Morphology [PDF]
BiomoleculesMitochondrial lipid metabolism is an emerging regulator of neuronal regeneration, yet its role remains poorly defined. We investigated the function of phosphatidylserine decarboxylase (PSD), a mitochondrial enzyme that converts phosphatidylserine to ...
Sean D. Meehan +4 more
doaj +2 more sources
Correction: Wang et al. Phosphatidylserine Decarboxylase Promotes Ferroptosis Through STAT3/GPX4 Signaling in Gastric Cancer. Curr. Issues Mol. Biol. 2026, 48, 300 [PDF]
Current Issues in Molecular BiologyIn the original publication [...]
Li Wang +12 more
doaj +2 more sources
Exploring the molecular mechanism of EGCG in preventing obesity-induced precocious puberty based on serum metabolomics and molecular docking [PDF]
Frontiers in NutritionObjectiveObesity-induced precocious puberty presents serious health risks to adolescents. Building on our previous finding that epigallocatechin gallate (EGCG) exhibits a preventive effect on obesity-induced precocious puberty, the present study aims to ...
Shiyu Gao +20 more
doaj +2 more sources