Results 31 to 40 of about 41,016 (180)

Characterization of Phosphatidylserine Transport to the Locus of Phosphatidylserine Decarboxylase 2 in Permeabilized Yeast [PDF]

Journal of Biological Chemistry, 2001
In yeast, nascent phosphatidylserine (PtdSer) can be transported to the mitochondria and Golgi/vacuole for decarboxylation to synthesize phosphatidylethanolamine (PtdEtn). In strains with a psd1Delta allele for the mitochondrial PtdSer decarboxylase, the conversion of nascent PtdSer to PtdEtn can serve as an indicator of lipid transport to the locus of
W I, Wu, D R, Voelker
openaire   +2 more sources

Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro

Journal of Lipid Research, 2023
Liver function indicators are often impaired in patients with type 2 diabetes mellitus (T2DM), who present higher concentrations of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyl transferase than individuals without diabetes ...
Hu Xu, Weizu Li, Lei Huang, Xinyu He, Bei Xu, Xueqing He, Wentong Chen, Yaoxing Wang, Wenjun Xu, Sheng Wang, Qin Kong, Youzhi Xu, Wenjie Lu   +12 more
doaj   +1 more source

Porin 1 Modulates Autophagy in Yeast

Cells, 2021
Autophagy is a cellular recycling program which efficiently reduces the cellular burden of ageing. Autophagy is characterised by nucleation of isolation membranes, which grow in size and further expand to form autophagosomes, engulfing cellular material ...
Filomena Broeskamp, Elizabeth S. M. Edrich, Oskar Knittelfelder, Lisa Neuhaus, Thorsten Meyer, Jonas Heyden, Lukas Habernig, Florian Kreppel, Campbell W. Gourlay, Patrick Rockenfeller   +9 more
doaj   +1 more source

Coordinate regulation of phosphatidylserine decarboxylase in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1991
Regulation of the activity of the mitochondrial enzyme phosphatidylserine decarboxylase (PSD) was measured in vitro by using membrane preparations from wild-type and mutant strains of Saccharomyces cerevisiae. PSD specific activity was not affected by carbon source, and on all carbon sources, the highest specific activity was observed in cells entering
E, Lamping, S D, Kohlwein, S A, Henry, F, Paltauf   +3 more
openaire   +2 more sources

Action of the highly purified, membrane-bound enzyme phosphatidylserine decarboxylase Escherichia coli toward phosphatidylserine in mixed micelles and erythrocyte ghosts in the presence of surfactant. [PDF]

, 1975
Phosphatidylserine decarboxylase, Escheichia coli, was purified to near-homogeneity by the procedure of Dowhan, W., Wickner, W. T., and Kennedy, E. P. ((1974) J. Biol. Chem.
Warner, TG, Dennis, EA, TG Warner, EA Dennis   +3 more
core   +1 more source

The enzymes of phospholipid synthesis in Clostridium butyricum

Journal of Lipid Research, 1980
We have examined extracts of Clostridium butyricum for several enzymes of phospholipid synthesis. Membrane particles were shown to catalyze the formation of CDP-diglyceride from [3H]CTP and phosphatidic acid.
P Silber, R P Borie, H Goldfine
doaj   +1 more source

Characterization of the Gateway Decarboxylase for Psilocybin Biosynthesis [PDF]

, 2022
The l ‐tryptophan decarboxylase PsiD catalyzes the initial step of the metabolic cascade to psilocybin, the major indoleethylamine natural product of the “magic” mushrooms and a candidate drug against major depressive disorder.
Bernhard Rupp, Werten, Sebastiaan, Tim Schäfer, Sebastiaan Werten, Dirk Hoffmeister, Kramer, Kristina, Schäfer, Tim, Hoffmeister, Dirk, Rupp, Bernhard, Kristina Kramer   +9 more
core   +1 more source

PISD is a mitochondrial disease gene causing skeletal dysplasia, cataracts, and white matter changes

Life Science Alliance, 2019
This work demonstrates that pathogenic variants in PISD cause mitochondrial disease and suggests a novel mechanistic link whereby impaired lipid content in the inner mitochondrial membrane alters the activity of inner mitochondrial membrane proteases ...
Tian Zhao, Caitlin M Goedhart, Pingdewinde N Sam, Rasha Sabouny, Susanne Lingrell, Adam J Cornish, Ryan E Lamont, Francois P Bernier, David Sinasac, Jillian S Parboosingh, Jean E Vance, Steven M Claypool, A Micheil Innes, Timothy E Shutt   +13 more
doaj   +1 more source

Impaired phosphatidylethanolamine metabolism activates a reversible stress response that detects and resolves mutant mitochondrial precursors

iScience, 2021
Summary: Phosphatidylethanolamine (PE) made in mitochondria has long been recognized as an important precursor for phosphatidylcholine production that occurs in the endoplasmic reticulum (ER). Recently, the strict mitochondrial localization of the enzyme
Pingdewinde N. Sam, Elizabeth Calzada, Michelle Grace Acoba, Tian Zhao, Yasunori Watanabe, Anahita Nejatfard, Jonathan C. Trinidad, Timothy E. Shutt, Sonya E. Neal, Steven M. Claypool   +9 more
doaj   +1 more source

Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator. [PDF]

Sci Rep, 2018
Isolation of tumor-initiating cells currently relies on markers that do not reflect essential biologic functions of these cells. We proposed to overcome this limitation by isolating tumor-initiating cells based on enhanced migration, a function tightly ...
Chen YC, Humphries B, Brien R, Gibbons AE, Chen YT, Qyli T, Haley HR, Pirone ME, Chiang B, Xiao A, Cheng YH, Luan Y, Zhang Z, Cong J, Luker KE, Luker GD, Yoon E.   +16 more
europepmc   +2 more sources