Rewiring mitochondrial phosphatidylethanolamine metabolism identifies new and unaccounted trafficking steps [PDF]
Journal of Lipid ResearchThe distinct compositions of the two mitochondrial membranes are generated through a combination of phospholipids that mitochondria can make and those they take; both processes depend on a series of distinct lipid trafficking steps.
Rashima Prem +4 more
doaj +2 more sources
TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids [PDF]
Emerging Microbes and InfectionsHuman T-cell immunoglobulin and mucin domain 1 (TIM-1) facilitates infection of re-emerging viruses, including alphaviruses, through its phosphatidylserine (PS) binding domain.
Ju Eun Yoo +9 more
doaj +2 more sources
Age‐related changes in central nervous system phosphatidylserine decarboxylase activity [PDF]
Journal of Neuroscience Research, 2002 A significant portion of brain phosphatidylethanolamine (PE) is synthesized by a pathway involving the mitochondrial enzyme phosphatidylserine decarboxylase (PSDC), in a process by which phosphatidylserine (PS) is transferred from the endoplasmic ...
Frederico M. López +5 more
core +5 more sources
Doxorubicin Inhibits Phosphatidylserine Decarboxylase and Modifies Mitochondrial Membrane Composition in HeLa Cells [PDF]
International Journal of Molecular Sciences, 2020 Patrick Moreau +2 more
exaly +2 more sources
An Improved and Highly Selective Fluorescence Assay for Measuring Phosphatidylserine Decarboxylase Activity [PDF]
Journal of Biological Chemistry, 2020 Choukri Ben Mamoun +2 more
exaly +2 more sources
Preparation of Asymmetric Liposomes Using a Phosphatidylserine Decarboxylase. [PDF]
Biophys J, 2018 Lipid asymmetries between the outer and inner leaflet of the lipid bilayer exist in nearly all biological membranes. Although living cells spend great effort to adjust and maintain these asymmetries, little is known about the biophysical phenomena within asymmetric membranes and their role in cellular function.
Drechsler C +7 more
europepmc +5 more sources
Se-enriched yeast improves meat quality through glycerophospholipid metabolism in finishing pigs: insights from a multi-omics analysis [PDF]
Journal of Animal Science and BiotechnologyBackground The improvement of meat quality by selenium (Se) supplementation has been well documented; however, the effects and underlying mechanisms by which Se-enriched yeast modulates meat quality remain unclear.
Xiangqi Qiu +9 more
doaj +2 more sources
High-Throughput Screening for Phosphatidylserine Decarboxylase Inhibitors Using a Distyrylbenzene-Bis-Aldehyde (DSB-3)-Based Fluorescence Assay [PDF]
Journal of Biological Chemistry, 2019 Choukri Ben Mamoun +2 more
exaly +2 more sources
Multitiered and Cooperative Surveillance of Mitochondrial Phosphatidylserine Decarboxylase 1. [PDF]
Mol Cell Biol, 2017 Phosphatidylserine decarboxylase 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane, must undergo an autocatalytic self-processing event to gain activity. Autocatalysis severs the protein into a large membrane-anchored β subunit that noncovalently associates with the small α ...
Ogunbona OB +3 more
europepmc +4 more sources
Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. [PDF]
J Biol Chem, 2012 The inner mitochondrial membrane plays a crucial role in cellular lipid homeostasis through biosynthesis of the non-bilayer-forming lipids phosphatidylethanolamine and cardiolipin. In the yeast Saccharomyces cerevisiae, the majority of cellular phosphatidylethanolamine is synthesized by the mitochondrial phosphatidylserine decarboxylase 1 (Psd1).
Horvath SE +6 more
europepmc +5 more sources