Results 51 to 60 of about 41,016 (180)

Cytoplasmic Lipid Membrane Biogenesis in Prokaryotes: From Soluble Lipid Building Blocks to a Dynamic and Functional Boundary Layer [PDF]

Chembiochem
Lipid membranes are fundamental to all prokaryotic life. Besides acting as barrier, by orienting as hydrophobic bilayer, lipids are involved in a wide variety of other cellular processes. As a consequence, prokaryotic membranes are dynamic entities that switch their lipid composition as required; a process that requires tight interplay with the lipid ...
Gan S, Exterkate M.
europepmc   +2 more sources

New perspectives on the regulation of intermembrane glycerophospholipid traffic

Journal of Lipid Research, 2003
In eukaryotes, phosphatidylserine (PtdSer) can serve as a precursor of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho), which are the major cellular phospholipids.
Dennis R. Voelker
doaj   +1 more source

Non-apoptotic activity of the mitochondrial protein SMAC/Diablo in lung cancer: Novel target to disrupt survival, inflammation, and immunosuppression

Frontiers in Oncology, 2022
Mitochondrial SMAC/Diablo induces apoptosis by binding the inhibitor of apoptosis proteins (IAPs), thereby activating caspases and, subsequently, apoptosis.
Swaroop Kumar Pandey, Anna Shteinfer-Kuzmine, Vered Chalifa-Caspi, Varda Shoshan-Barmatz, Varda Shoshan-Barmatz   +4 more
doaj   +1 more source

Function‐centered back‐tracing refines obesity‐associated gut microbiome signals beyond abundance‐based profiling

iMetaOmics, EarlyView.
By integrating taxonomic and functional profiling of 1543 adult gut metagenomes, this study identified microbial taxa and enzymatic functions associated with increasing Body Mass Index. Function‐centered taxonomic back‐tracing of branched‐chain amino acid transaminase, nucleotide diphosphatase, and phosphatidylserine decarboxylase revealed only limited
Silvia Petraro, Chiara Tarracchini, Leonardo Mancabelli, Gabriele Andrea Lugli, Francesca Turroni, Marco Ventura, Christian Milani   +6 more
wiley   +1 more source

Phosphatidylserine synthase and phosphatidylserine decarboxylase are essential for cell wall integrity and virulence in Candida albicans [PDF]

Molecular Microbiology, 2010
SummaryPhospholipid biosynthetic pathways play crucial roles in the virulence of several pathogens; however, little is known about how phospholipid synthesis affects pathogenesis in fungi such as Candida albicans. A C. albicans phosphatidylserine (PS) synthase mutant, cho1Δ/Δ, lacks PS, has decreased phosphatidylethanolamine (PE), and is avirulent in a
Ying-Lien, Chen, Anthony E, Montedonico, Sarah, Kauffman, John R, Dunlap, Fu-Min, Menn, Todd B, Reynolds   +5 more
openaire   +2 more sources

Tafazzin modulates cellular phospholipid composition to regulate AML stemness

Molecular & Cellular Oncology, 2019
Tafazzin is a mitochondrial enzyme necessary for the remodeling of the phospholipid cardiolipin. Seneviratne and Xu et al. demonstrated that Tafazzin-mediated phospholipid production regulates stemness in Acute Myeloid Leukemia (AML). Tafazzin influenced
Ayesh K. Seneviratne, Mingjing Xu, Aaron D. Schimmer   +2 more
doaj   +1 more source

Diverse Uses of Lantibiotics: Exploring New Approaches to Combat Antibiotic Resistance

Medicine Advances, EarlyView.
This review illustrates lantibiotics as an alternative therapeutic approach to combat antibiotic resistance, highlighting their diverse sources, including plants, insects, animals, and microorganisms. It further emphasizes their broad therapeutic potential, including antibacterial, antifungal, antiparasitic, antiviral, and anticancer activities (GA ...
Gopalarethinam Janani, Shangavy Pandiarajan, Kunal Biswas, Manickam Rajkumar, Agnishwar Girigoswami, Koyeli Girigoswami   +5 more
wiley   +1 more source

Sterol effects on phospholipid biosynthesis in the yeast strain GL7.

Journal of Lipid Research, 1990
Cells of the yeast sterol auxotroph GL7 were grown on either ergosterol or cholesterol to mid-logarithmic phase and total membrane fractions prepared. Activities of phospholipid biosynthetic enzymes in the two cell types were determined.
M Ramgopal, M Zundel, K Bloch
doaj   +1 more source

PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.

PLoS Genetics, 2020
The major glycerophospholipid phosphatidylethanolamine (PE) in the nervous system is essential for neural development and function. There are two major PE synthesis pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum (ER) and the ...
Haifang Zhao, Tao Wang
doaj   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source