Results 71 to 80 of about 41,016 (180)

An Assembly of Proteins and Lipid Domains Regulates Transport of Phosphatidylserine to Phosphatidylserine Decarboxylase 2 in \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e [PDF]

, 2014
Background: The machinery for interorganelle phosphatidylserine (PtdSer) transport is poorly defined at the molecular level. Results: Molecular interaction studies identify specific protein-protein and protein-lipid interactions in PtdSer transport ...
Voelker, Dennis R., Loewen, Christopher J. R., Riekhof, Wayne R., Chan, Mallory M., Wu, Wen-I, Jones, Jennifer L., Nikrad, Mrinalini   +6 more
core  

Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis

Scientific Reports, 2021
Phosphatidylethanolamine (PE), a major component of the cellular membrane across all domains of life, is synthesized exclusively by membrane-anchored phosphatidylserine decarboxylase (PSD) in most bacteria.
Gyuhyeok Cho, Eunju Lee, Jungwook Kim
doaj   +1 more source

CSF and plasma lipid profiling predicts risk of cognitive impairment in cognitively unimpaired older adults

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Age‐related cognitive decline and Alzheimer's disease (AD) are strongly influenced by lipid metabolism, yet how central and peripheral lipid profiles relate to disease risk before symptom onset remains unclear. METHODS We performed comprehensive shotgun lipidomics in cerebrospinal fluid (CSF) and plasma from cognitively unimpaired
Takahisa Kanekiyo, Launia J. White, Hongping Ye, Yingxue Ren, Jason D. Ulrich, Ana‐Caroline Raulin, Alla Alnobani, Chengjie Xiong, Yan W. Asmann, Maria Vassilaki, Alicia Algeciras‐Schimnich, Junmin Peng, Fatima S. Amtashar, Suzanne E. Schindler, David M. Holtzman, Guojun Bu, Ronald C. Petersen, Michael G. Heckman, Xianlin Han   +18 more
wiley   +1 more source

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Phosphatidylserine polarization is required for proper Cdc42 localization and for development of cell polarity. [PDF]

, 2010
We used genetically-encoded fluorescent probes to visualize the distribution of phosphatidylserine (PS) in live S. cerevisiae. The majority of the PS was found to reside in the cytosolic leaflet of the plasma membrane.
Gregory Fairn, Sergio Grinstein
core  

Characterization of Sec14 Domain–Containing Proteins in the Malaria Parasite Plasmodium falciparum

Molecular Microbiology, Volume 126, Issue 4, Page 412-432, October 2026.
During asexual blood‐stage development, P. falciparum Sec14 proteins display distinct localizations suggesting specialized roles in lipid exchange. PfSec14‐1 initially localizes to the nucleus before moving to the ER and Golgi alongside PfSec14‐4 during schizogony.
Florian Lauruol, Dominik Šťastný, J. Pedro Fernandez‐Murray, Christopher R. McMaster, Peter Griač, Dave Richard   +5 more
wiley   +1 more source

A Yeast Mutant Deleted of GPH1 Bears Defects in Lipid Metabolism.

PLoS ONE, 2015
In a previous study we demonstrated up-regulation of the yeast GPH1 gene under conditions of phosphatidylethanolamine (PE) depletion caused by deletion of the mitochondrial (M) phosphatidylserine decarboxylase 1 (PSD1) (Gsell et al., 2013, PLoS One. 8(10)
Martina Gsell, Ariane Fankl, Lisa Klug, Gerald Mascher, Claudia Schmidt, Claudia Hrastnik, Günther Zellnig, Günther Daum   +7 more
doaj   +1 more source

Organelle Crosstalk and Metabolic Reprogramming in Idiopathic Pulmonary Fibrosis: Mechanisms and Therapeutic Implications

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease of unknown cause, marked by excessive deposition of extracellular matrix (ECM) components such as collagen. This pathological accumulation results in progressive destruction of the lung architecture and ultimately leads to respiratory failure.
Yining Zhang, Ling Teng, Limin Gong, Yuandong Fu, Minyi Qian   +4 more
wiley   +1 more source

Structural characterization of Escherichia coli phosphatidylserine decarboxylase.

Journal of Biological Chemistry, 1988
Phosphatidylserine decarboxylase of Escherichia coli is one of a small group of pyruvoyl-dependent enzymes (Satre, M., and Kennedy, E.P. (1978) J. Biol. Chem. 253, 479-483). The DNA sequence of the structural gene (psd) and partial protein sequence studies demonstrate that the enzyme contains two nonidentical subunits, alpha (Mr = 7,332) and beta (Mr =
Q X, Li, W, Dowhan
openaire   +2 more sources

Multi‐omics insights into salinity tolerance in African bermudagrass

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract African bermudagrass (Cynodon transvaalensis Burtt‐Davy) is a key parent species used to produce interspecific hybrid bermudagrass (Cynodon dactylon × C. transvaalensis). Due to the increasing use of non‐potable water for landscape irrigation, salt stress has become a major concern in the turfgrass industry.
Prabha Adhikari, Shuhao Yu, Mingying Xiang, Yanqi Wu, Felipe Cevallos, Charles Fontanier, Justin Moss, Dennis Martin   +7 more
wiley   +1 more source