Delivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives
MedComm, Volume 7, Issue 7, July 2026.Schematic illustration of four emerging CRISPR–Cas delivery platforms defined by distinct design principles and structural features: virus‐mimicking nanosystems (e.g., VLPs), cell‐derived extracellular vesicles, cell‐penetrating peptides, and stimuli‐responsive scaffolds. These platforms enable spatiotemporally controlled delivery of RNPs, mRNA, or DNA
Meijia Yang +9 more
wiley +1 more source
Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng +6 more
wiley +1 more source
Transport of phosphatidylserine from microsmes to the inner mitochondrial membrane in brain tissue
, 1993 Phosphatidylserine was labeled by incubating rat brain homogenates with [3-I4C]serine in the presence of Ca2+ (base-exchange conditions). Some labeled phosphatidylethanolamine also forms, in spite of the inhibition of Ca" on phosphatidylserine ...
ARIENTI G. +3 more
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Journal of Lipid Research, 2008 Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are two aminophospholipids whose metabolism is interrelated. Both phospholipids are components of mammalian cell membranes and play important roles in biological processes such as apoptosis and ...
Jean E. Vance
doaj +1 more source
Glu- and Lys-forms of plasminogen differentially affect phosphatidylserine exposure on the platelet surface [PDF]
, 2017 Plasminogen/plasmin system is known for its ability to support hemostatic balance of blood. However, plasminogen may be considered as an adhesive ligand and in this way could affect the functioning of blood cells. We showed that exogenous Lys-plasminogen,
Zhernossekov, D.D. +9 more
core +1 more source
Mitochondrial Fragmentation and Abnormal Function of Drosophila Phosphatidylserine Decarboxylase Gene Mutation [PDF]
, 2019 학위논문(석사)--서울대학교 대학원 :사범대학 과학교육과(생물전공),2019. 8. 전상학.Dysfunction of the mitochondria and subsequent development of ROS is one of the causes of degenerative neurological diseases.
이계훈
core
Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]
, 1993 The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M. +7 more
core +1 more source
Regulation of yeast phospholipid biosynthetic genes in phosphatidylserine decarboxylase mutants [PDF]
Journal of Bacteriology, 1997 In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol. Chem. 268:24580-24590, 1993; P. J. Trotter, J. Pedretti, and D. R. Voelker, J. Biol. Chem.
openaire +2 more sources
, 1989 Phosphatidylserine decarboxylase of E. coli, a cytoplasmic membrane protein, catalyzes the formation of phosphatidylethanolamine, the principal phospholipid of the organism.
Li, Qiao-Xin
core +1 more source
Maturation of the malarial phosphatidylserine decarboxylase is mediated by high affinity binding to anionic phospholipids. [PDF]
J Biol Chem, 2023 Choi JY +3 more
europepmc +1 more source