Results 111 to 120 of about 41,016 (180)

Modulating Ubiquinone Biosynthesis Rescues Mitochondrial Dysfunction by Genetic Interaction in a Phosphatidylethanolamine (PE)-Deficient Disease Model

Antioxidants
Mitochondrial dysfunctions are often associated with cellular aging as well as metabolic disorders. Therapeutic strategies for rewiring mitochondrial stress signaling in a disease context could be beneficial.
Lavanya Vadupu, Vijay Aditya Mavuduru, Writoban Basu Ball   +2 more
doaj   +1 more source

Fingolimod normalizes metabolic signatures associated with synaptic plasticity and memory in APP/PS1 model: Sphingosine-1-phosphate receptor a therapeutic target for Alzheimer’s

Scientific Reports
Previously, our metabolomic, transcriptomic, and genomic studies characterized the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease, and we demonstrated that FTY720, a sphingosine-1-phospahate receptor modulator approved for ...
Karel Kalecký, Luna Buitrago, Juan Marcos Alarcon, Abanish Singh, Teodoro Bottiglieri, Rima Kaddurah-Daouk, A. Iván Hernández   +6 more
doaj   +1 more source

Phosphatidylserine in atherosclerosis

, 2016
International audiencePurpose of review: It is now widely acknowledged that phosphatidylserine is a multifunctional bioactive lipid. In this review, we focus on the function of phosphatidylserine in modulating cholesterol metabolism, influencing ...
Darabi, Maryam, Kontush, Anatol
core   +1 more source

Disclosing antifungal activity of Huangqin decoction upon Trichophyton mentagrophytes and exploring its potential inhibitory mechanisms through transcriptome sequencing and qRT-PCR

Scientific Reports
Trichophyton mentagrophytes (T. mentagrophytes) is a prevalent pathogen that causes human and animal dermatophytosis. The clinical treatment of the infections is challenging due to the prolonged treatment duration, limited efficacy, antifungal resistance
Su-Qing Yang, You-Jin Ge, Cheng-Ying Shen   +2 more
doaj   +1 more source

Phosphatidylserine Decarboxylase 2 of Saccharomyces cerevisiáe [PDF]

Journal of Biological Chemistry, 1995
Pamela J. Trotter, John Pedretti, Rachel Yates, Dennis R. Voelker   +3 more
openaire   +1 more source

Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. [PDF]

, 2015
Glycine decarboxylase (GLDC) acts in the glycine cleavage system to decarboxylate glycine and transfer a one-carbon unit into folate one-carbon metabolism. GLDC mutations cause a rare recessive disease non-ketotic hyperglycinemia (NKH).
Brosnan, ME, Greene, ND, Leung, KY, Savery, D, Prunty, H, Brosnan, JT, Copp, AJ, Heales, S, Pai, YJ, Hutchin, T   +9 more
core  

Phosphatidylserine synthase in the endoplasmic reticulum of Toxoplasma is essential for its lytic cycle in human cells

Journal of Lipid Research
Glycerophospholipids have emerged as a significant contributor to the intracellular growth of pathogenic protist Toxoplasma gondii. Phosphatidylserine (PtdSer) is one such lipid, attributed to the locomotion and motility-dependent invasion and egress ...
Dimitrios Alexandros Katelas, Rosalba Cruz-Miron, Ruben D. Arroyo-Olarte, Jos F. Brouwers, Ratnesh Kumar Srivastav, Nishith Gupta   +5 more
doaj   +1 more source

Covalently bound substrate at the regulatory site triggers allosteric enzyme activation [PDF]

, 2008
The mechanism by which the enzyme pyruvate decarboxylase from yeast is activated allosterically has been elucidated. A total of seven three-dimensional structures of the enzyme, of enzyme variants or of enzyme complexes form two yeast species (three of ...
Steffen Kutter, König, Stephan, Kutter, Steffen, Manfred Weiss, Golbik, Ralph, Michael Spinka, Stephan König, Georg Wille, Ralph Golbik, Spinka, Michael, Weiss, Manfred S., Wille, Georg   +11 more
core  

Monoamine Biosynthesis via a Noncanonical Calcium-Activatable Aromatic Amino Acid Decarboxylase in Psilocybin Mushroom

, 2018
Aromatic l-amino acid decarboxylases (AAADs) are a phylogenetically diverse group of enzymes responsible for the decarboxylation of aromatic amino acid substrates into their corresponding aromatic arylalkylamines.
Chun-Ting Liu (1881562), Tomáš Pluskal (2083438), Jing-Ke Weng (2820115), Michael Patrick Torrens-Spence (6065099), Yin Kwan Chung (6065102)   +4 more
core   +1 more source

Homeostatic response of phospholipid pathways to PCYT2 deficiency and impaired de Novo synthesis of phosphatidylethanolamine

Scientific Reports
PCYT2 is the key regulatory enzyme in the biosynthesis of phosphatidylethanolamine (PE) via the CDP-ethanolamine Kennedy pathway. Deficiencies in this gene have been linked to metabolic, neurological, and cardiac disorders; however, most studies report ...
Roya Iraji, Michaela St. Germain, Sophie Grapentine, Leanne Perreira, Laila Schenkel, Sara Al-Douri, Lyn M. Hillyer, Clara E. Cho, David W. L. Ma, Marica Bakovic   +9 more
doaj   +1 more source