Results 171 to 180 of about 10,710 (280)

Lipid scavenging by the Lyme disease spirochete Borrelia burgdorferi. [PDF]

PLoS Pathog
Gwynne PJ, Bourgeois JS, Pandit A, Asara JM, Hu LT.   +4 more
europepmc   +1 more source

Structural Characterization, β‐Cyclodextrin Polymer Interaction, and Biological Assessment of the N‐Terminal Peptide from the RPD‐1 Big Defensin of Ruditapes p hilippinarum

Chemistry–Methods, Volume 6, Issue 5, May 2026.
Defensins are a large and ancient family of host–defence peptides present across vertebrates, invertebrates, and plants, where they play a crucial role in innate immunity. Among them, big defensins represent a structurally distinctive subfamily characterized by a hydrophobic N‐terminal domain and a cysteine‐rich C‐terminal β‐defensin‐like domain. Here,
Rita Turnaturi, Giuseppa Augello, Giuseppe Nocito, Marcello Tagliavia, Stefania Zimbone, Rosalia Pellitteri, Giuseppina Sabatino, Giuseppe Di Natale, Michele F. M. Sciacca, Milo Malanga, Antonino Mazzaglia, Melchiorre Cervello, Giuseppe Pappalardo   +12 more
wiley   +1 more source

Rosa roxburghii‐Derived Exosome‐Like Nanovesicles Alleviate Ulcerative Colitis Based on Th17/Treg Immune Balance and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 3, May 2026.
Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang, Yan Zeng, Guoying Liu, Hai Zou, Jie Wang, Jun Zhang, Ketao Jin, Zhangfeng Zhong, Xiaozhou Mou   +8 more
wiley   +1 more source

Maternal food-derived signals oscillate in the fetal suprachiasmatic nucleus before its circadian clock develops. [PDF]

PLoS Biol
Sládek M, Houdek P, Čajka T, Sumová A.   +3 more
europepmc   +1 more source

Lipidome Analysis of Cancer Cells and Their Extracellular Vesicles Reveals Cancer‐Type‐Specific Lipid Signatures and Enables the Design of EV‐Mimetic Liposomes

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Lipid metabolism reprogramming is a hallmark of cancer, yet the global lipidome of cancer cells and their extracellular vesicles (EVs) remains poorly understood. Using mass spectrometry, we analyzed the lipid profiles of a panel of human cancer and non‐cancer cell lines along with their secreted EVs.
Noélie Douanne, Yousra Benslimane, Rubén R. López, Prisca Bustamante, Thupten Tsering, Yunxi Chen, Laura Kienzle, Masoud Ghasemi, Lorne Taylor, Yuning Chen, Anaïs Toreja Boutin, David Juncker, Catherine Mounier, Vahé Nerguizian, Julia V. Burnier   +14 more
wiley   +1 more source

Inhibition of phosphatidylethanolamine biosynthesis by S‐adenosylmethionine [PDF]

FEBS Letters, 1976
Plantavid, M., Maget-Dana, R., Douste-Blazy, L.   +2 more
openaire   +2 more sources

Proteolytic control of mitochondrial protein translocases

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Lara Kroczek, Thomas Langer
wiley   +1 more source

Gaining insights into MmpL3: combining structural and computational approaches to unlock transport and inhibitor‐binding mechanisms

Acta Crystallographica Section D, Volume 82, Issue 5, Page 550-570, May 2026.
This study investigates the mycobacterial membrane protein MmpL3, a key target for new antituberculosis drugs, by combining high‐resolution crystallography and computational simulations. It reveals how the inhibitor UPAR‐1109 binds to MmpL3, providing detailed insights into the function and flexibility of the protein and supporting the rational design ...
Satoshi Murakami, Domenico Marson, Eiki Yamashita, Bruno Broshka, Ui Okada, Maho Aoki, Giannamaria Annunziato, Erik Laurini, Emanuele Carosati, Marco Pieroni   +9 more
wiley   +1 more source

Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study. [PDF]

Lipids Health Dis
Landstra EN, Lohner V, Tavares JF, Diers K, Koch A, Breteler MMB.   +5 more
europepmc   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source