Results 191 to 200 of about 387,101 (335)

Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis [PDF]

, 2001
Andrew Foey, Patricia Green, Brian M. J. Foxwell, Marc Feldmann, Fionula M. Brennan   +4 more
openalex   +1 more source

Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains

, 2021
Jongyun Myeong, Cheon-Gyu Park, Byung‐Chang Suh, Bertil Hille   +3 more
openalex   +2 more sources

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

PIP4K2C: an emerging fulcrum for multiple diseases. [PDF]

Nat Rev Drug Discov
Pozzetti L, Mishra M, Einav S, Asquith CRM.   +3 more
europepmc   +1 more source

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP ₂ ) sensitivity of I _Ks to modulate channel activity

, 2011
Yang Li, Mark A. Zaydman, Dick Wu, Jingyi Shi, Michael Guan, Brett Virgin-Downey, Jianmin Cui   +6 more
openalex   +2 more sources

Clinical implications of PD‐L1 expression in oncogene‐driven NSCLC: Differential responses to targeted agents and immune checkpoint inhibitors

International Journal of Cancer, EarlyView.
What's New? PD‐L1 is a reliable biomarker for predicting immunotherapy efficacy in patients with non‐small‐cell lung cancer lacking oncogenic driver mutations. However, its significance in patients with driver mutations remains unclear. In this study of 273 patients with stage IV non–‐small‐cell lung cancer harboring diverse driver alterations and PD ...
Xiaoxiao Fan, Chenxi Wei, Minjun Rong, Shengnan Wang, Jiaying Wang, Xiaohan Wang, Xiao Han, Xue Meng   +7 more
wiley   +1 more source

A new functional assay reveals that membrane binding is critical for overactivation of the phosphoinositide 3-kinase H1047R mutant. [PDF]

J Biol Chem
Papafotika A, Pavlaki M, Lazani V, Karamani VE, Aggelidis D, Kapella A, Kotzampasi DM, Agianian B, Efstratiadis A, Cournia Z, Christoforidis S.   +10 more
europepmc   +1 more source

An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl-phosphatidylinositol mimics some of the metabolic actions of insulin.

, 1992
David E. Misek, A R Saltiel
openalex   +1 more source

Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways [PDF]

, 2001
Catherine M. Cahill, Guri Tzivion, Nargis Nasrin, Scott Ogg, Justin Dore, Gary Ruvkun, Maria Alexander-Bridges   +6 more
openalex   +1 more source

Reciprocal regulation of vacuolar calcium transport and V-ATPase activity, and the effects of Phosphatidylinositol 3,5-bisphosphate [PDF]

, 2020
Gregory E. Miner, David A. Rivera‐Kohr, Chi Zhang, Katherine D. Sullivan, Annie Guo, Rutilio A. Fratti   +5 more
openalex   +1 more source