Results 211 to 220 of about 37,360 (258)

Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase

Tetrahedron, 2000
Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Naoko Morisaki, Koji Morita, Asuka Nishikawa, Noriyuki Nakatsu, Yasuhisa Fukui, Yuichi Hashimoto, Ryuichi Shirai   +6 more
openaire   +1 more source

Phosphatidylinositol synthesis in mycobacteria

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
The metabolism and synthesis of an important mycobacterial lipid component, phosphatidylinositol (PI), and its metabolites, was studied in Mycobacterium smegmatis and M. smegmatis subcellular fractions. Little is known about the synthesis of PI in prokaryotic cells. Only a cell wall fraction (P60) in M.
Salman M, Lonsdale JT, Besra GS, Brennan PJ   +3 more
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Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

Cancer Letters, 2012
This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
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Phosphatidylinositol liposomes opsonized by concanavalin a stimulate phosphatidylinositol turnover in macrophages

Biochemical and Biophysical Research Communications, 1986
We have previously found that concanavalin A binds specifically to inositol and phosphatidylinositol. In the present study we demonstrate that binding of concanavalin A to liposomes containing phosphatidylinositol influences the uptake of such liposomes by macrophages.
N M, Wassef, C R, Alving
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Anti‐inflammatory actions of phosphatidylinositol

European Journal of Immunology, 2011
AbstractChronic inflammatory T‐cell‐mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T‐cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less‐toxic alternatives.
Dieren, Jolanda, Oosterhuis, Ytje, Raatgeep, Rolien, Kortleve, Dicky, Lambers, Margaretha, van der Woude, C.J., Kuipers, Ernst, Snoek, GT, Potman, R, Lambrecht, Bart, Hammad, H (Hamida), Samsom, Janneke, Nieuwenhuis, EES   +12 more
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The structural requirement of phosphatidylinositols as substrate of phosphatidylinositol 3-kinase

Tetrahedron Letters, 1999
Abstract Synthetic distearate phosphatidylinositol (PI) was not phosphorylated by PI 3-kinase. The fatty acids at glycerol sn -2 must be as short as octanoic acid or less to act as a substrate of PI 3-kinase.
Ryuichi Shirai, Koji Morita, Asuka Nishikawa, Noriyuki Nakatsu, Yasuhisa Fukui, Naoko Morisaki, Yuichi Hashimoto   +6 more
openaire   +1 more source

Phosphatidylinositol phosphate kinases.

Journal of endocrinological investigation, 2004
Phosphatidylinositol 4,5-bisphosphate is a multi-functional lipid, whose proposed functions now number more than twenty, covering many aspects of cell biology in several different subcellular compartments. The enzymes primarily responsible for synthesizing this lipid, the Type I phosphatidylinositol 4-phosphate 5-kinases, are therefore a tightly ...
Giudici, ML, Hinchliffe, KA, Irvine, RF
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Phosphatidylinositol-transfer protein and cellular phosphatidylinositol metabolism

Biochemical Society Transactions, 1987
P A, Van Paridon, P, Somerharju, K W, Wirtz   +2 more
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Effect of neomycin on glycosyl-phosphatidylinositol and phosphatidylinositol system of Tetrahymena.

Microbios, 1996
Neomycin does not inhibit but increases the incorporation of 32P into phosphatidylinositols of Tetrahymena. This elevation is due to neomycin inhibition on the turnover of the phosphatidylinositol (PI) system. Neomycin also prevents the synthesis of glycosyl-phosphatidylinositol (GPI).
P, Kovács, G, Csaba
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Review of Phosphatidylinositol Phosphate Kinase in Phosphatidylinositol Signaling Pathway

2014
Phosphatidylinositol signaling pathway is an important signal transduction pathway that plays critical roles in multiple cell processes first demonstrated in animal cells. Research evidences have shown that although not exactly the same as it is in yeast and mammalian cells, phosphatidylinositol signaling pathway also exists in plant cells and is ...
openaire   +1 more source