Results 241 to 250 of about 363,126 (392)

Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils. [PDF]

, 1983
T Takenawa, Yoshimi Homma, Yuki Nagai
openalex   +1 more source

Inhibition of mTOR attenuates the initiation and progression of BRCA1‐associated mammary tumors

Cancer Communications, Volume 45, Issue 4, Page 486-490, April 2025.
Hye Jung Baek, Geun Hee Han, Eun Joo Cho, Jihao Xu, Min Kyung Ki, Eun Jung Park, Tae Hyun Kim, Dong Hoon Shin, Heesun Cheong, Chu‐Xia Deng, Sung Chul Lim, Chang‐il Hwang, Daehee Hwang, Sang Soo Kim   +13 more
wiley   +1 more source

Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)

ChemMedChem, Volume 20, Issue 8, April 14, 2025.
Analogs of the aminosteroid SHIP inhibitor 3α‐aminocholestane (3AC) have been synthesized and tested. Deletion of the C17 alkyl chain improves water solubility, however these analogs inhibit both SHIP1 and SHIP2. Enzyme kinetics imply that these aminosteroids are competitive inhibitors, and a model of the inhibitors within the active site of SHIP is ...
Angela M. Pacherille, Dennis R. Viernes, Chiara Pedicone, Sandra Fernandes, Otto M. Dungan, Shawn Dormann, Daniel R. Wallach, Raki Sudan, Robbie Brooks, Christopher M. Russo, Kyle T. Howard, Michael S. Cosgrove, William G. Kerr, John D. Chisholm   +13 more
wiley   +1 more source

Ergosterol-induced immune response in barley involves phosphorylation of phosphatidylinositol phosphate metabolic enzymes and activation of diterpene biosynthesis. [PDF]

New Phytol
Saake P, Brands M, Endeshaw AB, Stolze SC, Westhoff P, Balcke GU, Hensel G, Holton N, Zipfel C, Tissier A, Nakagami H, Zuccaro A.   +11 more
europepmc   +1 more source

Aluminum fluoride induces phosphatidylinositol turnover, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells. [PDF]

, 1987
J J O'Shea, Kevin B. Urdahl, H T Luong, Thomas M. Chused, Lawrence E. Samelson, Richard D. Klausner   +5 more
openalex   +1 more source

Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we?

ChemMedChem, Volume 20, Issue 6, March 15, 2025.
This review goes beyond the famous MD‐2/TLR4‐mediated recognition of LPS, pointing the attention on other immune detection systems and their impact on human physiology and pathology. Understanding these additional pathways is key for the development of pharmacologically active molecules to modulate the immune response and to conceive new strategies to ...
Stefania De Chiara, Luca De Simone Carone, Roberta Cirella, Emanuela Andretta, Alba Silipo, Antonio Molinaro, Marcello Mercogliano, Flaviana Di Lorenzo   +7 more
wiley   +1 more source

Molecular Mechanisms of Pathogenic Fungal Virulence Regulation by Cell Membrane Phospholipids. [PDF]

J Fungi (Basel)
Li Y, Wang H, Wang H, Wang T, Wu D, Wei W.   +5 more
europepmc   +1 more source

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Proceedings of the National Academy of Sciences of the United States of America, 2001
L. Mayo, D. Donner
semanticscholar   +1 more source

Release of carcinoembryonic antigen from human colon cancer cells by phosphatidylinositol-specific phospholipase C. [PDF]

, 1988
Todd L. Sack, James R. Gum, M G Low, Y.S. Kim   +3 more
openalex   +1 more source

Deciphering Important Metabolic Pathways through Reaction Pair Prediction with a Siamese Transformer Network

Chemistry–Methods, EarlyView.
A deep learning‐based method Siamese transformer reaction pair (STRP) prediction is presented for identifying important pathways in untargeted LC‐MS/MS metabolomics. STRP accurately predicts metabolic reaction pairs from known metabolites and tandem mass spectra of unannotated metabolic features, which enhance the utility of untargeted metabolomics ...
Han Bao, Xinxin Wang, Jinhui Zhao, Bin Wang, Xinjie Zhao, Chunxia Zhao, Xin Lu, Guowang Xu   +7 more
wiley   +1 more source