Results 241 to 250 of about 387,101 (335)

A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca ²⁺ -activated Cl ⁻ channel ANO1 (TMEM16A) [PDF]

, 2019
Kuai Yu, Tao Jiang, YuanYuan Cui, Emad Tajkhorshid, H. Criss Hartzell   +4 more
openalex   +1 more source

Phosphatidylinositol-3-Kinase Pathway [PDF]

Journal of Thoracic Oncology, 2012
openaire   +2 more sources

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

The Role of a Newly Synthesized Antimicrobial Peptide (KK)₂-KWWW-NH₂ in Modulating Phosphatidylinositol Monolayer Properties in the Presence of Ascorbic Acid. [PDF]

Int J Mol Sci
Golonka I, Sebastiańczyk A, Łukasiewicz IW, Greber KE, Sawicki W, Musiał W.   +5 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Pescadillo ribosomal biogenesis factor 1 as a therapeutic target in tumor immunotherapy. [PDF]

World J Gastroenterol
Yu J, Yu B, Ge FL, Ren ZG.
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Identifying the mediating role of immune cells on the relationship between plasma lipidomes and PCOS: a two-step Mendelian randomization analysis. [PDF]

J Ovarian Res
Liu L, Liu B, Li M, Qin L.
europepmc   +1 more source

Phosphatidylinositol 3-Kinase Activity Is Important for Progesterone-Induced Xenopus Oocyte Maturation

, 1993
Anthony J. Muslin, Anke Klippel, Lewis T. Williams   +2 more
openalex   +2 more sources

Epigallocatechin‐3‐Gallate Suppresses Glioma by Targeting Integrin αvβ3/FAK/ERK Signaling Axis and Matrix Metalloproteinases

Phytotherapy Research, EarlyView.
EGCG suppresses glioma progression by targeting integrin αvβ3/FAK/ERK signaling and inhibiting MMP‐2/MMP‐9‐mediated ECM degradation, thereby blocking proliferation, migration, invasion, and promoting apoptosis. ABSTRACT Epigallocatechin‐3‐gallate (EGCG), the most abundant and biologically active catechin in green tea, has been widely reported to ...
Rui Sun, Yonghan Pan, Ning Yang, Bing Kang, Hong Xiao, Xianglong Tang, Taiping Li, Mengjie Zhao   +7 more
wiley   +1 more source