Results 21 to 30 of about 188,850 (296)

Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver

Journal of Lipid Research, 2021
: Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 (MBOAT7).
Mingfeng Xia, Preethi Chandrasekaran, Shunxing Rong, Xiaorong Fu, Matthew A. Mitsche   +4 more
doaj   +1 more source

Identification and Characterization of a Novel Basic Helix-Loop-Helix Transcription Factor of Phospholipid Synthesis Regulation in Aspergillus niger

Frontiers in Microbiology, 2020
The synthesis of phospholipids relies on a sort of genes, whose promoter regions contain inositol-sensitive upstream activation sequence (UASINO) and are regulated by the basic helix-loop-helix (bHLH)-type ino2/ino4 transcription factor (TF) pair.
Hongzhi Dong, Hongzhi Dong, Dou Yu, Dou Yu, Bin Wang, Bin Wang, Li Pan, Li Pan   +7 more
doaj   +1 more source

Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans

mBio, 2022
Phosphatidylinositol lipids regulate key processes, including vesicle trafficking and cell polarity. A recent study identified novel roles for phosphatidylinositol 4-phosphate (PI4P) in the plasma membrane of the fungal pathogen Candida albicans ...
James B. Konopka
doaj   +1 more source

A Role for Phosphoinositides in Regulating Plant Nuclear Functions

Frontiers in Plant Science, 2012
Nuclear localized inositol phospholipids and inositol phosphates are important for regulating many essential processes in animal cells such as DNA replication, recombination, RNA processing, mRNA export and cell cycle progression.
Catherine B Dieck, Wendy F Boss, Imara Yasmin Perera   +2 more
doaj   +1 more source

In vitro mimicry of essential fatty acid deficiency in human endothelial cells by TNFα impact of ω-3 versus ω-6 fatty acids

Journal of Lipid Research, 2002
Severe endothelial abnormalities are a prominent feature in sepsis with cytokines such as tumor necrosis factor (TNF)α being implicated in the pathogenesis.
Konstantin Mayer, Reinhold Schmidt, Marion Muhly-Reinholz, Tina Bögeholz, Stephanie Gokorsch, Friedrich Grimminger, Werner Seeger   +6 more
doaj   +1 more source

Mammalian Phosphatidylinositol 4‐Kinases [PDF]

IUBMB Life, 2003
AbstractThree phosphatidylinositol 4‐kinase isoforms, PI4K 230, 92 and 55 have been cloned and sequenced allowing a much wider characterization than the previously employed enzymological typing into type II and III enzymes. PI4K 230 and 92 contain a highly conserved catalytic core, PI4K55 one with a much lower degree of similarity.
Ludwig M G, Heilmeyer, György, Vereb, György, Vereb, Annamária, Kakuk, Ilona, Szivák   +4 more
openaire   +3 more sources

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development[S]

Journal of Lipid Research, 2016
The expansion of lipid droplets (LDs) and the differentiation of preadipocytes are two important aspects of mammalian lipid storage. In this study, we examined the role of CDP-diacylglycerol (DAG) synthases (CDSs), encoded by CDS1 and CDS2 genes in ...
Yanfei Qi, Tamar S. Kapterian, Ximing Du, Qianli Ma, Weihua Fei, Yuxi Zhang, Xun Huang, Ian W. Dawes, Hongyuan Yang   +8 more
doaj   +1 more source

Chronic cholesterol depletion increases F-actin levels and induces cytoskeletal reorganization via a dual mechanism

Journal of Lipid Research, 2022
Previous work from us and others has suggested that cholesterol is an important lipid in the context of the organization of the actin cytoskeleton.
Parijat Sarkar, G. Aditya Kumar, Sandeep Shrivastava, Amitabha Chattopadhyay   +3 more
doaj   +1 more source

Recognizing Phosphatidylinositol 3-Phosphate [PDF]

Cell, 2001
Phosphatidylinositol 3-phosphate directs the endosomal localization of regulatory proteins by binding to FYVE and PX domains. New structures of these domains complexed with the phosphoinositide headgroup show how interactions with phosphate and hydroxyl groups differentiate this lipid from all others.
James H. Hurley, Saurav Misra, Gregory J. Miller   +2 more
openaire   +3 more sources

Engineering of a novel optimized platform for sublingual delivery with novel characterization tools: in vitro evaluation and in vivo pharmacokinetics study in human

Drug Delivery, 2017
The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical ...
Nadia M. Morsi, Ghada A. Abdelbary, Ahmed H. Elshafeey, M. Abdallah Ahmed   +3 more
doaj   +1 more source