Results 21 to 30 of about 363,126 (392)

Phosphatidylinositol Stabilizes Fluid-Phase Liposomes Loaded with a Melphalan Lipophilic Prodrug

Pharmaceutics, 2021
Previously, a liposomal formulation of a chemotherapeutic agent melphalan (Mlph) incorporated in a fluid lipid bilayer of natural phospholipids in the form of dioleoylglyceride ester (MlphDG) was developed and the antitumor effect was confirmed in mouse ...
Daria Tretiakova, Irina Le-Deigen, Natalia Onishchenko, Judith Kuntsche, Elena Kudryashova, Elena Vodovozova   +5 more
doaj   +1 more source

Hsp90 picks PIKKs via R2TP and Tel2 [PDF]

, 2014
Phosphatidylinositol-3 kinase-like kinases (PIKKs) are dependent on Hsp90 for their activation via the R2TP complex and Tel2. In this issue of Structure, Pal and colleagues present the molecular mechanism by which PIKKs are recruited to ...
Boulon, Cara K. Vaughan, Horejsí, Izumi, Kakihara, Li, Omran, Pal, Takai, Tarkar   +9 more
core   +1 more source

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate*

Journal of Biological Chemistry, 1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated that overexpression of PTEN, a putative tumor suppressor, reduced insulin-induced PtdIns(3,4,5)P3 production in human 293 ...
T. Maehama, J. Dixon
semanticscholar   +1 more source

PIP5KIβ Selectively Modulates Apical Endocytosis in Polarized Renal Epithelial Cells [PDF]

, 2013
Localized synthesis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] at clathrin coated pits (CCPs) is crucial for the recruitment of adaptors and other components of the internalization machinery, as well as for regulating actin dynamics during ...
A Benmerah, A Gassama-Diagne, A Le Bivic, A Oztan, AL Rozelle, AV Oleinikov, BA Potter, BM Collins, Brianne E. Docter, Christina M. Szalinski, Christopher J. Guerriero, CJ Guerriero, CJ Maples, CJ Merrifield, CJ Merrifield, CN Antonescu, D Padron, DJ James, DK Strickland, F Gong, F Martin-Belmonte, F Martin-Belmonte, G Apodaca, G Apodaca, G Di Paolo, G Di Paolo, G Rohde, G Spudich, G Spudich, Gerard Apodaca, H Ishihara, H Ishihara, HY Naim, HY Naim, I van den Bout, J Hyman, J Zheng, JC Loijens, JM Anderson, Joshua Z. Rappoport, JR Henkel, JZ Rappoport, KM Vasudevan, KM Weixel, L Fang, LA Volpicelli-Daley, LA Volpicelli-Daley, LM Traub, M Bens, M Jost, M Krauss, M Nagai, MA Barbieri, MA Lemmon, MA Lokuta, MA Puthenveedu, Manojkumar A. Puthenveedu, MG Ford, Núria M. Pastor-Soler, O Cremona, O Idevall-Hagren, Ora A. Weisz, P Khandelwal, P Varnai, PC Stolt, PP Breitfeld, R Rohatgi, R Rohatgi, R Rojas, R Rojas, R Zoncu, RV Stahelin, RW Holz, S Benesch, S Boulant, S Cui, S Hardy, S Mukherjee, SF Bairstow, SJ Mundell, SK Mishra, T Hyman, T Itoh, TA Gottlieb, V Haucke, Wily G. Ruiz, Y Aikawa, Y Wang, Youssef Rbaibi, YS Mao   +89 more
core   +3 more sources

Genetic Analysis and Molecular Mapping of the Quantitative Trait Loci Governing Low Phytic Acid Content in a Novel LPA Rice Mutant, PLM11

Plants, 2020
Breeding rice varieties with a low phytic acid (LPA) content is an effective strategy to overcome micronutrient deficiency in a population which consume rice as a staple food.
Prem Chand Gyani, Haritha Bollinedi, Subbaiyan Gopala Krishnan, Kunnummal Kurungara Vinod, Archana Sachdeva, Prolay Kumar Bhowmick, Ranjith Kumar Ellur, Mariappan Nagarajan, Ashok Kumar Singh   +8 more
doaj   +1 more source

Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans

mBio, 2022
Phosphatidylinositol lipids regulate key processes, including vesicle trafficking and cell polarity. A recent study identified novel roles for phosphatidylinositol 4-phosphate (PI4P) in the plasma membrane of the fungal pathogen Candida albicans ...
James B. Konopka
doaj   +1 more source

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]

, 2012
Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah, Jean, Steve, Kiger, Amy, Robinson, Fred L, Schmidt, Eric J   +4 more
core   +1 more source

Phosphatidylinositol(4,5)bisphosphate and Phosphatidylinositol(4)phosphate in Plant Tissues [PDF]

Plant Physiology, 1989
Pea (Pisum sativum) leaf discs or swimming suspensions of Chlamydomonas eugametos were radiolabeled with [(3)H]myo-inositol or [(32)P]Pi and the lipids were extracted, deacylated, and their glycerol moieties removed. The resulting inositol trisphosphate and bisphosphate fractions were examined by periodate degradation, reduction and dephosphorylation ...
A. J. Letcher, D. J. Lander, Robin F. Irvine, Alan P. Dawson, Alan Musgrave, Bjørn K. Drøbak   +5 more
openaire   +3 more sources

Genomic conservation and putative downstream functionality of the phosphatidylinositol signalling pathway in the cnidarian-dinoflagellate symbiosis

Frontiers in Microbiology, 2023
The mutualistic cnidarian–dinoflagellate symbiosis underpins the evolutionary success of stony corals and the persistence of coral reefs. However, a molecular understanding of the signalling events that lead to the successful establishment and ...
Immy A. Ashley, Sheila A. Kitchen, Lucy M. Gorman, Arthur R. Grossman, Clinton A. Oakley, David J. Suggett, Virginia M. Weis, Sabrina L. Rosset, Simon K. Davy   +8 more
doaj   +1 more source

Association of Factor V Secretion with Protein Kinase B Signaling in Platelets from Horses with Atypical Equine Thrombasthenia. [PDF]

, 2015
BackgroundTwo congenital bleeding diatheses have been identified in Thoroughbred horses: Glanzmann thrombasthenia (GT) and a second, novel diathesis associated with abnormal platelet function in response to collagen and thrombin stimulation.Hypothesis ...
Blevins, G, Norris, JW, Pombo, M, Shirley, E, Tablin, F   +4 more
core   +1 more source