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Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins [PDF]

Biochemical Society Symposia, 2007
PtdIns is synthesized at the endoplasmic reticulum and its intracellular distribution to other organelles can be facilitated by lipid transfer proteins [PITPs (phosphatidylinositol transfer proteins)]. In this review, I summarize the current understanding of how PITPs are regulated by phosphorylation, how can they dock to membranes to exchange their ...
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Oncogenes and Phosphatidylinositol Turnover

Annals of the New York Academy of Sciences, 1986
Products of phosphatidylinositol turnover have recently been implicated as regulators of cell growth and differentiation. Transformation of cells in culture by infection with certain viruses (Rous sarcoma virus, Kirsten sarcoma virus, and polyoma virus) or by transfection with the oncogenes carried by these viruses affect the steady-state level of ...
L. Fleischman, Thomas M. Roberts, David R. Kaplan, Lewis C. Cantley, Suresh B. Chahwala, Brian Schaffhausen, Malcolm Whitman   +6 more
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Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.

New England Journal of Medicine, 2018
The Central Role of PI3K in Cell Signaling Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development.
M. Goncalves, B. Hopkins, L. Cantley
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Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase

Tetrahedron, 2000
Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Noriyuki Nakatsu, Yuichi Hashimoto, Koji Morita, Naoko Morisaki, Ryuichi Shirai, Asuka Nishikawa, Yasuhisa Fukui   +6 more
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Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma.

Journal of Clinical Oncology, 2017
Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant activity against PI3K-α and -δ isoforms, has demonstrated efficacy and a
M. Dreyling, A. Santoro, L. Mollica, S. Leppä, G. Follows, G. Lenz, W. Kim, A. Nagler, P. Panayiotidis, J. Demeter, M. Özcan, M. Kosinova, K. Bouabdallah, F. Morschhauser, D. Stevens, D. Trevarthen, M. Giurescu, L. Cupit, Li Liu, K. Köchert, H. Seidel, C. Peña, S. Yin, F. Hiemeyer, J. Garcia-Vargas, B. Childs, P. Zinzani   +26 more
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Glycosyl Phosphatidylinositol Anchor

Nephron Experimental Nephrology, 1998
Recently, we and others demonstrated the unique potential for glycosyl phosphatidylinositol (GPI) anchored proteins to transfer from one cell membrane to another in a process we termed ‘painting’. The GPI-anchored proteins were shown to transfer intact and functional.
Guerard W. Byrne, John S. Logan, David L. Kooyman   +2 more
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Phosphatidylinositol 3‐kinase

BioEssays, 1994
AbstractCurrently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date.
Rosana Kapeller, Lewis C. Cantley
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Modulation of phosphatidylinositol turnover by liposomes containing phosphatidylinositol

1987
Publisher Summary This chapter discusses the methods for preparing liposomes for coating (opsonizing) the liposomes with immunoglobulin M (IgM) antibodies and complement or opsonizing with concanavalin A (Con A) to promote phagocytosis and resulting increased phosphatidylinositol (PI) turnover, for obtaining and culturing mouse peritoneal macrophages,
Carl R. Alving, Nabila M. Wassef
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Phosphatidylinositol synthesis in mycobacteria

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
The metabolism and synthesis of an important mycobacterial lipid component, phosphatidylinositol (PI), and its metabolites, was studied in Mycobacterium smegmatis and M. smegmatis subcellular fractions. Little is known about the synthesis of PI in prokaryotic cells. Only a cell wall fraction (P60) in M.
Salman M, Lonsdale JT, Besra GS, Brennan PJ   +3 more
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The conformational behaviour of phosphatidylinositol

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
The temperature dependence of the 1H-NMR spectrum of phosphatidylinositol (PI) in d6-dimethylsulphoxide (DMSO) shows that the hydroxy groups at C2 and at C6 of the inositol ring are internally hydrogen-bonded. This probably implies a trans/gauche conformation for the phosphate/inositol linkage.
Philip M. Hansbro, David G. Reid, Richard J. Bushby, Stephen J. Byard   +3 more
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