Results 61 to 70 of about 363,126 (392)

Editorial: Membrane lipids in T cell functions [PDF]

, 2018
Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core   +1 more source

Differentiating human phospholipase A2's activity toward phosphatidylinositol, phosphatidylinositol phosphate and phosphatidylinositol bisphosphate

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Phospholipase A2's (PLA2's) constitute a superfamily of enzymes that hydrolyze the sn-2 fatty acyl chain on glycerophospholipids. We have previously reported that each PLA2 Type shows a unique substrate specificity for the molecular species it hydrolyzes, especially the acyl chain that is cleaved from the sn-2 position and to some extent the polar ...
Daiki, Hayashi, Edward A, Dennis
openaire   +2 more sources

A synthesis of dioctanoyl phosphatidylinositol

Tetrahedron: Asymmetry, 2009
A synthesis of the naturally occurring enantiomer of phosphatidylinositol is reported. A resolution strategy, using camphor as a chiral auxiliary is employed to obtain the desired, enantiomerically pure, inositol derivative. Dioctanoyl lipid chains are appended to the molecule, which are shorter than the naturally occurring lipid chains, providing the ...
Elliott, T, Nemeth, J, Swain, SA, Conway, S   +3 more
openaire   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

RASSF4: Regulator of plasma membrane PI(4,5)P2. [PDF]

, 2017
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/
Balla, Chang, Chen, Cockcroft, Dickson, Eamonn J. Dickson, Hille, Kim, Liou, Nakatsu, Prakriya, Rawat, van der Weyden   +12 more
core   +1 more source

Insulin provokes co-ordinated increases in the synthesis of phosphatidylinositol, phosphatidylinositol phosphates and the phosphatidylinositol–glycan in BC3H-1 myocytes [PDF]

Biochemical Journal, 1988
BC3H-1 myocytes were cultured in the presence of [3H]inositol or [3H]glucosamine during their entire growth cycle to ensure that all lipids containing inositol and glucosamine were labelled to isotopic equilibrium or maximal specific radioactivity. After such labelling, a lipid (or group of lipids), which was labelled with both inositol and glucosamine,
Farese, R. V., Cooper, D. R., Konda, T. S., Nair, G., Standaert, M. L., Pollet, R. J.   +5 more
openaire   +4 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Engineering of a novel optimized platform for sublingual delivery with novel characterization tools: in vitro evaluation and in vivo pharmacokinetics study in human

Drug Delivery, 2017
The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical ...
Nadia M. Morsi, Ghada A. Abdelbary, Ahmed H. Elshafeey, M. Abdallah Ahmed   +3 more
doaj   +1 more source

Loss of the Arabidopsis thaliana P4-ATPases ALA6 and ALA7 Impairs Pollen Fitness and Alters the Pollen Tube Plasma Membrane

Frontiers in Plant Science, 2015
Members of the P4 subfamily of P-type ATPases are thought to create and maintain lipid asymmetry in biological membranes by flipping specific lipids between membrane leaflets. In Arabidopsis, 7 of the 12 Aminophospholipid ATPase (ALA) family members are
Stephen C McDowell, Rosa L López-Marqués, Taylor eCohen, Elizabeth eBrown, Alexa eRosenberg, Michael G Palmgren, Jeffrey F Harper   +6 more
doaj   +1 more source

Pseudonocardia parietis sp. nov., from the indoor environment [PDF]

, 2009
A Gram-positive, rod-shaped, non-endospore-forming, mycelium-forming actinobacterium (04-St-002(T)) was isolated from the wall of an indoor environment colonized with moulds.
Busse, Hans-Jürgen, Kämpfer, Peter, Schäfer, Jenny   +2 more
core   +1 more source