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BEX2 regulates autophagy by inhibiting PIK3CA-p85 interaction in non-small-cell lung cancer cells. [PDF]
Cell Commun SignalWang Y +6 more
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Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling. [PDF]
J Biol ChemGhosh C +4 more
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BioEssays, 1994
AbstractCurrently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date.
R, Kapeller, L C, Cantley
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AbstractCurrently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date.
R, Kapeller, L C, Cantley
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Plant Phosphatidylinositol 3-Kinase
2009Phosphatidylinositol 3-kinase (PI3K) phosphorylates the D-3 position of phosphoinositides. In Arabidopsis, only one PI3K exists, which belongs to the class-III PI3K subfamily which makes phosphatidylinositol 3-phosphate (PtdIns3P). The single AtPI3K gene is essential for survival, since loss of its expression results in lethality.
Lee, Y., Munnik, T., Lee, Y.
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Phosphatidylinositol 3-Kinase in Myogenesis
Trends in Cardiovascular Medicine, 1997Phosphatidylinositol 3-kinase (PI 3-kinase) has been cloned and characterized in a wide range of organisms. PI 3-kinases are activated by a diversity of extracellular stimuli and are involved in multiple cell processes such as cell proliferation, protein trafficking, cell motility, differentiation, regulation of cytoskeletal structure, and apoptosis ...
P, Kaliman, A, Zorzano
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Computational Design of Phosphatidylinositol 3-Kinase Inhibitors
ASSAY and Drug Development Technologies, 2022One of the most sought-after therapeutic targets for treating human cancers is the phosphoinositide 3-kinase; PI3k is an integral part of the PI3K/protein kinase B signaling arcade. This pathway is frequently activated in malignancies. Drug resistance and dose-limiting adverse effects are currently associated challenges with the existing anticancer ...
Isha Rani, Anju Goyal, M. Sharma
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Phosphatidylinositol-3-Kinase Inhibition in Follicular Lymphoma
Hematology/Oncology Clinics of North America, 2020Chemoimmunotherapy is the standard frontline treatment for symptomatic or high tumor burden follicular lymphoma. Better understanding of the molecular mechanisms of lymphomagenesis has led to the development of drugs targeting these pathways. The phosphatidylinositol-3-kinase pathway is an important signaling pathway in B-cell lymphomas. Three drugs in
Ryan C, Lynch, Ajay K, Gopal
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Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase
Tetrahedron, 2000Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Naoko Morisaki +6 more
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