Results 261 to 270 of about 154,752 (304)

Phosphatidylinositol 3-kinase related kinases

Current Opinion in Immunology, 1996
Studies in yeast, files and mammalian cells have uncovered a novel family of signal-transducing kinases which bear an evolutionary relationship to phosphatidylinositol 3-kinase. These phosphatidylinositol 3-kinase related enzymes play critical roles in DNA repair, V(D)J recombination and cell-cycle checkpoints, and their dysfunction leads to clinical ...
openaire   +2 more sources

Cancer-specific mutations in phosphatidylinositol 3-kinase

Trends in Biochemical Sciences, 2007
Cancer-specific mutations in the catalytic subunit of phosphatidylinositol 3-kinase (PI3K) p110 alpha occur in diverse tumors in frequencies that can exceed 30%. The majority of these mutations map to one of three hot spots in the gene, and the rest are distributed over much of the PI3K coding sequence.
Peter K, Vogt, Sohye, Kang, Marc-André, Elsliger, Marco, Gymnopoulos   +3 more
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Exercise activates the phosphatidylinositol 3-kinase pathway

Molecular Brain Research, 2005
Physical exercise is known to enhance psychological well-being and coping capacity. Voluntary physical exercise in rats also robustly and rapidly up-regulates hippocampal brain-derived neurotrophic factor (BDNF) mRNA levels, which are potentiated following a regimen of chronic antidepressant treatment. Increased BDNF levels are associated with enhanced
Michael J, Chen, Amelia A, Russo-Neustadt   +1 more
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Phosphatidylinositol 3′ Kinase Signaling in Mammary Tumorigenesis

Journal of Mammary Gland Biology and Neoplasia, 2001
Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol 3' kinase pathway plays a seminal role in cell death suppression or "survival signaling." Over the past 5 years, the molecular mechanisms by which this pathway exerts its death suppressive effects have ...
M P, Scheid, J R, Woodgett
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New phosphatidylinositol 3-kinase inhibitors for cancer

Expert Opinion on Investigational Drugs, 2011
Cancer treatment is moving away from conventional cytotoxic drugs and towards agents that target specific proteins important to cancer development or survival. The PI3K signaling axis is an important pathway involved in myriad human malignancies. Inhibition of this axis is a promising therapeutic approach for several cancers.This article reviews ...
Daniel W, Bowles, Antonio, Jimeno
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Expression of Phosphatidylinositol-3 Kinase in Lung Cancer

Bulletin of Experimental Biology and Medicine, 2000
The expression of phosphatidylinositol-3 kinase in tumors and homologous tissues from 29 patients with lung cancer, 5 patients with lung metastases of various tumors, and some non-tumorous pulmonary diseases was studied by Western blot analysis.
E S, Gershtein, V A, Shatskaya, K K, Laktionov, N E, Kushlinskii, M A, Krasil'nikov   +4 more
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Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring

Journal of Medicinal Chemistry, 2014
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell proliferation, metabolism, migration, survival, and responses to diverse stresses including DNA damage.
Martin, Andrs, Jan, Korabecny, Daniel, Jun, Zdenek, Hodny, Jiri, Bartek, Kamil, Kuca   +5 more
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Phosphatidylinositol 3-Kinase Pathway

2014
The phosphatidylinositol 3-kinase (PI3K) pathway is one of the signalling pathways activated following the interaction of a growth factor with a tyrosine kinase receptor (TKR). It follows a parallel path to the MAP kinase pathway, and similarly, it operates after binding a phosphotyrosine residue of the receptor to an adapter protein.
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Phosphatidylinositol 3-kinase

2006
  +4 more sources