Results 91 to 100 of about 192,293 (285)

Synaptic vesicle fusion promotes phosphatidylinositol 4-phosphate synthesis for efficient synaptic transmission

Cell Reports
Summary: Efficient synaptic vesicle (SV) recycling is essential for sustaining synaptic transmission. While the multiple roles of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) in SV recycling are well documented, presynaptic regulation of ...
Tomofumi Yoshida, Hiroyuki Kawano, Jumpei Omi, Tetsuya Hori, Yutaka Kobayashi, Naoto Saitoh, Junken Aoki, Shigeo Takamori   +7 more
doaj   +1 more source

Phosphatidylinositol 5 Phosphate 4-Kinase Regulates Plasma-Membrane PIP3 Turnover and Insulin Signaling

Cell Reports, 2019
Summary: Phosphatidylinositol 3,4,5-trisphosphate (PIP3) generation at the plasma membrane is a key event during activation of receptor tyrosine kinases such as the insulin receptor required for normal growth and metabolism. We report that in Drosophila,
Sanjeev Sharma, Swarna Mathre, Visvanathan Ramya, Dhananjay Shinde, Padinjat Raghu   +4 more
doaj   +1 more source

Kytococcus aerolatus sp. nov., isolated from indoor air in a room colonized with moulds [PDF]

, 2009
A Gram-positive, coccoid bacterial isolate (02-St-019/1(T)), forming beige pigmented colonies was obtained from an indoor air sample. Based on 16S rRNA gene sequence similarity studies it was determined that this isolate 02-St-019/1(T) belonged to the ...
Kämpfer, Peter, Martin, Karin, Schumann, Peter, Schäfer, Jenny   +3 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Activation of Phosphatidylinositol Kinase and Phosphatidylinositol-4-phosphate Kinase by cAMP in Saccharomyces cerevisiae

Journal of Biological Chemistry, 1989
In Saccharomyces cerevisiae, cAMP-dependent phosphorylation plays an essential role at the start of the cell cycle. It has also recently been demonstrated that the breakdown of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate and diacylglycerol is a requisite process for cell proliferation (Uno, I., Fukami, K., Kato, H., Takenawa ...
H, Kato, I, Uno, T, Ishikawa, T, Takenawa   +3 more
openaire   +2 more sources

Interfacial hydrolysis of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate by turkey erythrocyte phospholipase C [PDF]

Biochemical Journal, 1994
The activity of a beta-isoform of phospholipase C (PLC) partially purified from turkey erythrocyte cytosol was assayed using phospholipid monolayers formed at an air-water interface. PLC was rapidly purified at least 8000-fold by a sequence of ion-exchange, hydrophobic and heparin chromatographies.
S R, James, R A, Demel, C P, Downes
openaire   +2 more sources

Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. [PDF]

, 2012
Clathrin-coated vesicles mediate endocytosis and transport between the trans-Golgi network (TGN) and endosomes in eukaryotic cells. Clathrin adaptors play central roles in coat assembly, interacting with clathrin, cargo and membranes.
Costaguta, Giancarlo, Daboussi, Lydia, Payne, Gregory S   +2 more
core   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

OsPIPK-FAB, A Negative Regulator in Rice Immunity Unveiled by OsMBL1 Inhibition

Rice
Phosphatidylinositol signaling system plays a crucial role in plant physiology and development, phosphatidylinositol phosphate kinases (PIPKs) are one of the essential enzymes responsible for catalyzing the synthesis of phosphatidylinositol bisphosphate (
Ruina Zhang, Mengtian Pei, Shiyi Lin, Jing Chen, Jules Biregeya, Linlin Song, Changlin Peng, Pengcheng Jiang, Guo-dong Lu   +8 more
doaj   +1 more source