Results 131 to 140 of about 19,012 (341)

Multiscale Simulations Suggest a Mechanism for the Association of the Dok7 PH Domain with PIP-Containing Membranes.

PLoS Computational Biology, 2016
Dok7 is a peripheral membrane protein that is associated with the MuSK receptor tyrosine kinase. Formation of the Dok7/MuSK/membrane complex is required for the activation of MuSK.
Amanda Buyan, Antreas C Kalli, Mark S P Sansom   +2 more
doaj   +1 more source

Characterization of the Inositol Monophosphatase Gene Family in Arabidopsis

Frontiers in Plant Science, 2015
Synthesis of myo-inositol is crucial in multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. The myo-inositol monophosphatase (IMP) enzyme is required for the synthesis of myo-inositol, breakdown of
Aida eNourbakhsh, Eva eCollakova, Glenda E Gillaspy   +2 more
doaj   +1 more source

Analysis of weighted co-regulatory networks in maize provides insights into new genes and regulatory mechanisms related to inositol phosphate metabolism [PDF]

, 2016
Sub-network 1 and 2 of “magenta2”, node annotation.
Chunyi Zhang, Ling Jiang, Qianqian Zhao, Rumei Chen, Shaojun Zhang, Shuai Ma, Wenzhu Yang, Xiaojin Zhou, Xiaoqing Liu, Ye Li, Yunliu Fan   +10 more
core   +6 more sources

Citrus Flavonoids as Antimicrobials

Chemistry &Biodiversity, EarlyView.
Citrus flavonoids are powerful and versatile antimicrobials whose mechanism of action often involves disruption of the bacterial membrane, thereby minimizing antimicrobial resistance. This study provides a unified perspective. ABSTRACT Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant ...
Rosaria Ciriminna, Giovanna Li Petri, Giuseppe Angellotti, Rafael Luque, Anne‐Sylvie Fabiano Tixier, Francesco Meneguzzo, Mario Pagliaro   +6 more
wiley   +1 more source

Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice [PDF]

, 2009
The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Aebischer, Toni, Blackburn, Clare, Brand, Janko, Brinkmann, Volker, Hoffmann, Kirstin, Lippuner, Christoph, Paape, Daniel, Paterou, Athina, Richardson, Melville, Smith, Andrew   +9 more
core   +1 more source

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, Accepted Article.
Upon cell stimulation, mammalian cells activate various signaling proteins and lipids by recruiting their upstream regulators to the inner leaflet of the plasma membrane (PM), which in turn determines their cellular response. Therefore, artificially inducing protein translocation to the PM is an effective strategy for dissecting cell signaling networks
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

A phosphoinositide map at the shoot apical meristem in Arabidopsis thaliana

BMC Biology, 2018
Background In plants, the shoot apical meristem (SAM) has two main functions, involving the production of all aerial organs on the one hand and self-maintenance on the other, allowing the production of organs during the entire post-embryonic life of the ...
Thomas Stanislas, Matthieu Pierre Platre, Mengying Liu, Léa E. S. Rambaud-Lavigne, Yvon Jaillais, Olivier Hamant   +5 more
doaj   +1 more source

Phosphatidylinositol phosphates modulate interactions between the StarD4 sterol trafficking protein and lipid membranes. [PDF]

J Biol Chem, 2022
Zhang X, Xie H, Iaea D, Khelashvili G, Weinstein H, Maxfield FR.   +5 more
europepmc   +1 more source

Arabidopsis inositol phosphate kinases, IPK1 and ITPK1, constitute a metabolic pathway in maintaining phosphate homeostasis [PDF]

, 2018
Emerging studies have implicated a close link between inositol phosphate (InsP) metabolism and cellular phosphate (Pi) homeostasis in eukaryotes; however, whether a common InsP species is deployed as an evolutionarily conserved metabolic messenger to ...
Alcazar-Roman, Alexova, Auesukaree, Aung, Azevedo, Azevedo, Bari, Berridge, Boer, Bosch, Brearley, Brearley, Brearley, Brearley, Chamberlain, Chiou, Chiou, Cho, Choi, Clough, Curtis, Desai, Duff, Franco-Zorrilla, Gonzalez, Hammond, Hanke, Ho, Holford, Huang, Huang, Irvine, Kanehara, Karimi, Kim, Kuo, Kusano, Laha, Lee, Lee, Lee, Lemtiri-Chlieh, Lemtiri-Chlieh, Lin, Lin, Lin, Liu, Liu, Liu, Lonetti, Martin, Mosblech, Mulugu, Munnik, Munnik, Munnik, Murphy, Müller, Nagy, Norbis, Pant, Perera, Perera, Perera, Phillippy, Pradet, Puga, Raboy, Raboy, Rao, Rouached, Saiardi, Saiardi, Saiardi, Schell, Schneider, Secco, Secco, Shears, Stenzel, Stephens, Stephens, Stevenson-Paulik, Stevenson-Paulik, Sweetman, Szijgyarto, Torabinejad, Vajanaphanich, Voglmaier, Wang, Whiteford, Wild, Williams, Wilson, Wreggett, Wu, Wu, Wundenberg, Xiong, Xu, Xu, Yang, Yang, York, Zonia   +104 more
core   +2 more sources

Disruption of Retriever Function Impacts Retrograde Trafficking From Endosomes

Cell Biology International, EarlyView.
ABSTRACT Within endosomes cargo proteins are sorted and packaged into endosomal‐transport carriers (ETCs) enabling their delivery to other intracellular compartments. Retromer, a conserved multimeric protein complex, has defined functions in sorting cargo mediating formation of ETCs for both retrograde trafficking back to the trans‐Golgi network (TGN ...
Zebin Li, Zhe Yang, Rohan D. Teasdale
wiley   +1 more source