Results 151 to 160 of about 12,900 (249)

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Atg2/TRAPPIII-Ypt1 axis: deciphering the phagophore-ERES connection. [PDF]

Autophagy
Gómez-Sánchez R, Fromme JC, Ungermann C, Reggiori F.   +3 more
europepmc   +1 more source

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Treatment with Kinase Inhibitors Plus Myo-Inositol as Re-Differentiating Agents in Iodine-Refractory Thyroid Cancers. [PDF]

Life (Basel)
Giani C, Russo M, Lapi P, Profilo MA, Forleo R, Mazzi B, Ghirri A, Caresia L, Campennì A, Durante C, Corsello A, Morganti R, Unfer V, Paragliola RM, Barbaro D.   +14 more
europepmc   +1 more source

Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. [PDF]

Mol Pharmacol, 2009
Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE.   +5 more
europepmc   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

Phosphoinositide 3-kinase δ activity in patients with systemic lupus erythematosus. [PDF]

Front Immunol
Mirfazeli ES, Kharkar S, Tsang-A-Sjoe MWP, Papapietro O, Niewczas I, Parra Sanchez AR, Chandra A, Okkenhaug K, Bultink IEM, Mebius RE, Clark J, Voskuyl AE, Nejentsev S.   +12 more
europepmc   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Inositol and PIP2/PIP3 Ratio: At the Crossroad of the Biodynamic Interface Between Cells and Their Microenvironment. [PDF]

Biomolecules
Lentini G, Querqui A, Giuliani A, Verna R, Bizzarri M.   +4 more
europepmc   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source