Results 141 to 150 of about 19,012 (341)

Exploring phosphatidylinositol 5-phosphate 4-kinase function

Advances in Biological Regulation, 2015
The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our ...
Bulley, Simon J, Clarke, Jonathan H, Droubi, Alaa, Giudici, Maria-Luisa, Irvine, Robin F   +4 more
openaire   +5 more sources

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants [PDF]

, 2009
ACAP-type ARF GTPase activating proteins (ARF-GAPs) regulate multiple cellular processes, including endocytosis, secretion, phagocytosis, cell adhesion and cell migration.
Friml, Jiri, Fukuda, Hiroo, Koizumi, Koji, Nakano, Akihiko, Naramoto, Satoshi, Sawa, Shinichiro, Uemura, Tomohiro   +6 more
core   +1 more source

Exploring the Molecular Pathways Underlying the Anti‐Diabetic Effects of Millets

Food Safety and Health, EarlyView.
Millet consumption may modulate gluconeogenesis and glycolysis, enhance glucose transporter activity, increase leptin levels, inhibit the NF‐κB pathway, and mitigate oxidative and nitrosative stress. ABSTRACT Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemic conditions resulting from inadequate insulin production or ...
Akash Kumar, Nidhi N. Shah, Mehul R. Chorawala, Rekha Kaushik, Bhupendra Prajapati, Rahul Mehra   +5 more
wiley   +1 more source

Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length [PDF]

, 2016
Synthesis of inositol pyrophosphates through activation of Kcs1 plays an important role in the signalling response required for cell cycle progression after mating pheromone arrest. Overexpression of Kcs1 doubled the level of inositol pyrophosphates when
Azevedo, Banfic, Barberis, Bhandari, Blackburn, Divecha, Dubois, Folkman, Follo, Hanakahi, Irvine, Irvine, Lee, Odom, Saiardi, Saiardi, Saiardi, Shears, Shears, Steger, Szijgyarto, Thota, Tsui, Visnjic, York, York   +25 more
core   +1 more source

Differentiating human phospholipase A2's activity toward phosphatidylinositol, phosphatidylinositol phosphate and phosphatidylinositol bisphosphate

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Phospholipase A2's (PLA2's) constitute a superfamily of enzymes that hydrolyze the sn-2 fatty acyl chain on glycerophospholipids. We have previously reported that each PLA2 Type shows a unique substrate specificity for the molecular species it hydrolyzes, especially the acyl chain that is cleaved from the sn-2 position and to some extent the polar ...
Daiki, Hayashi, Edward A, Dennis
openaire   +2 more sources

How accurate is Poisson-Boltzmann theory for monovalent ions near highly charged interfaces? [PDF]

Langmuir 22, 5673-5681 (2006), 2006
Surface sensitive synchrotron x-ray scattering studies were performed to obtain the distribution of monovalent ions next to a highly charged interface. A lipid phosphate (dihexadecyl hydrogen-phosphate) was spread as a monolayer at the air-water interface to control surface charge density.
arxiv  

Probing the phosphoinositide 4,5-bisphosphate binding site of human profilin I [PDF]

, 1998
Background: Profilin is a widely and highly expressed 14 kDa protein that binds actin monomers, poly(L-proline) and polyp hosphoinositol lipids. It participates in regulating actin-filament dynamics that are essential for many types of cell motility.
Chaudhary, Anu, Chen, Jian, Gu, Qu-Ming, Kwiatkowski, David J., Prestwich, Glenn D., Witke, Walter   +5 more
core   +1 more source

Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes [PDF]

, 1984
Phillip T. Hawkins, Robert H. Michell, C J Kirk   +2 more
openalex   +1 more source