The Ca2+-dependent Binding of Calmodulin to an N-terminal Motif of the Heterotrimeric G Protein beta Subunit [PDF]
, 1997 Ca2+ ion concentration changes are critical events in signal transduction. The Ca2+-dependent interactions of calmodulin (CaM) with its target proteins play an essential role in a variety of cellular functions.
Liu, Mingyao +4 more
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Phosphatidylinositol-4-phosphate 5-Kinase Localized on the Plasma Membrane Is Essential for Yeast Cell Morphogenesis [PDF]
, 1998 Keiichi Homma +6 more
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Molecular Nutrition &Food Research, EarlyView.Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García +4 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Activation of the atrial K ACh channel by the βγ subunits of G proteins or intracellular Na + ions depends on the presence of phosphatidylinositol phosphates [PDF]
, 1998 Jin Sui +2 more
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Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu +3 more
wiley +1 more source
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. [PDF]
, 1996 Xiang-Dong Ren +5 more
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The Role of Magnesium in Liver Cirrhosis
Portal Hypertension &Cirrhosis, EarlyView.Magnesium is a vital mineral involved in over 300 enzymatic reactions, crucial for physiological functions. Its deficiency, common in liver cirrhosis patients, correlates with poor outcomes by affecting inflammation, oxidative stress, fibrosis, and immunity. This review explores magnesium's role in cirrhosis and its interaction with disease mechanisms.
Weiye Zeng +4 more
wiley +1 more source
The Phosphatidylinositol 3-Phosphate Binding Protein Vac1p Interacts with a Rab GTPase and a Sec1p Homologue to Facilitate Vesicle-mediated Vacuolar Protein Sorting [PDF]
, 1999 Gregory G. Tall +3 more
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A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets [PDF]
, 1998 Hrvoje Banfíƈ +5 more
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