The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Insulin Regulation of Glucose-6-phosphate Dehydrogenase Gene Expression Is Rapamycin-sensitive and Requires Phosphatidylinositol 3-Kinase [PDF]
, 1998 Asavari Wagle +3 more
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Clustering of Membrane Receptors: Insights from DNA Origami‐Based Approaches
Small, EarlyView.Receptor clustering critically influences cell signaling, yet its precise regulation remains elusive. This review highlights how DNA origami structures serve as nanoscale tools to uncover receptor organization and provide new insights into signal transduction.
Carmen M. Domínguez +1 more
wiley +1 more source
A Novel Phosphatidylinositol-5-phosphate 4-Kinase (Phosphatidylinositol-phosphate Kinase IIγ) Is Phosphorylated in the Endoplasmic Reticulum in Response to Mitogenic Signals [PDF]
, 1998 Toshiki Itoh +2 more
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Smart Molecules, EarlyView.A mitochondria‐targeted AIE photosensitizer, LIQ‐TPA‐TZ, was developed to fight against Candida infection. It can efficiently produce reactive oxygen species to kill Candida guilliermondii and eradicate biofilms. It not only disrupted the respiratory chain and affected the metabolism and energy supply but also reduced the fungi adhesion and filament ...
Kun‐Mei Liu +5 more
wiley +1 more source
skittles, a Drosophila Phosphatidylinositol 4-Phosphate 5-Kinase, Is Required for Cell Viability, Germline Development and Bristle Morphology, But Not for Neurotransmitter Release [PDF]
, 1998 Bassem A. Hassan +5 more
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Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy
Small Science, EarlyView.Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri +11 more
wiley +1 more source
Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy
VIEW, EarlyView.The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang +11 more
wiley +1 more source
Nuclear targeting of the β isoform of Type II phosphatidylinositol phosphate kinase (phosphatidylinositol 5-phosphate 4-kinase) by its α-helix 7 [PDF]
, 2000 Antonio Ciruela +3 more
openalex +1 more source