Results 201 to 210 of about 12,900 (249)

A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia. [PDF]

J Am Soc Nephrol
Chen C, Wang Z, Gao Y, Ellis MR, Ji B, Sieben CJ, Haycraft CJ, Croyle M, Aghevli A, Xu Q, Robichaud JH, He K, Chen C, Huang Y, Yoder BK, Hu J, Harris PC, Yu Y, Ling K.   +18 more
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Phosphatidylinositol and inositol phosphate metabolism

Journal of Cell Science, 2001
The six carbons that comprise the inositol ring can be phosphorylated in a combinatorial manner, generating a truly astonishing range of inositol phosphates and inositol lipids. Yet, somehow, the cell can distinguish and utilize several of these metabolites to specifically regulate a variety ...
K, Abel, R A, Anderson, S B, Shears
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Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

Cancer Letters, 2012
This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
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Phosphatidylinositol‐4‐phosphate: The Golgi and beyond

BioEssays, 2013
Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased
DE MATTEIS, Maria Antonietta, Wilson, Cathal, D'Angelo, Giovanni   +2 more
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Phosphatidylinositol phosphate kinases.

Journal of endocrinological investigation, 2004
Phosphatidylinositol 4,5-bisphosphate is a multi-functional lipid, whose proposed functions now number more than twenty, covering many aspects of cell biology in several different subcellular compartments. The enzymes primarily responsible for synthesizing this lipid, the Type I phosphatidylinositol 4-phosphate 5-kinases, are therefore a tightly ...
Giudici, ML, Hinchliffe, KA, Irvine, RF
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Phosphatidylinositol 4-Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase Assays

2013
Inositol lipid kinases are perhaps the easiest and most straightforward enzymes in the phosphoinositide pathway to analyze. In addition to monitoring lipid kinase-specific activity, lipid kinase assays can be used to quantify the inositol lipids present in isolated membranes (Jones et al., Methods Mol Biol 462:75-88, 2009).
Yang Ju, Im, Irena, Brglez, Catherine, Dieck, Imara Y, Perera, Wendy F, Boss   +4 more
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The phosphatidylinositol 4-phosphate 5-kinase family

Advances in Enzyme Regulation, 1996
The existence of a PIP5K family of enzymes has been suggested by Western blotting and purification of numerous PIP5Ks from various tissues and cell types. The erythrocyte has at least two PIP5Ks, named PIP5KI and PIP5KII, while the brain appears to have even more isoforms.
J C, Loijens, I V, Boronenkov, G J, Parker, R A, Anderson   +3 more
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General Synthesis of Phosphatidylinositol Phosphates

Phosphorus, Sulfur, and Silicon and the Related Elements, 1996
Abstract A general method for synthesis of 3-phosphorylated phosphatidylinositols is described. Phosphatidylinositol (PI) and phosphatidylinositol phosphates (PIPn), such as PI-4-P, PI-4,5-P2 undergo receptor-mediated cleavage by phosphatidylinositol-specific phospholipase C, and are precursors of second messengers important in diverse cellular ...
Robert Kubiak, Karol Bruzik
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Phox Homology Domains Specifically Bind Phosphatidylinositol Phosphates

Biochemistry, 2001
The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling.
X, Song, W, Xu, A, Zhang, G, Huang, X, Liang, J V, Virbasius, M P, Czech, G W, Zhou   +7 more
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