Results 91 to 100 of about 77,486 (386)

Identification of Metabolomic Signatures for Ischemic Hypoxic Encephalopathy Using a Neonatal Rat Model

Children, 2023
A study was performed to determine early metabolomic markers of ischemic hypoxic encephalopathy (HIE) using a Rice–Vannucci model for newborn rats.
Yulia Shevtsova, Chupalav Eldarov, Natalia Starodubtseva, Kirill Goryunov, Vitaliy Chagovets, Oleg Ionov, Egor Plotnikov, Denis Silachev   +7 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Lipidomic analysis identifies age-disease-related changes and potential new biomarkers in brain-derived extracellular vesicles from metachromatic leukodystrophy mice

Lipids in Health and Disease, 2022
Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative diseases ...
Melissa R. Pergande, Christina Kang, Diann George, Pearl A. Sutter, Stephen J. Crocker, Stephanie M. Cologna, Maria I. Givogri   +6 more
doaj   +1 more source

Lipid metabolism in Trypanosoma brucei: utilization of myristate and myristoyllysophosphatidylcholine for myristoylation of glycosyl phosphatidylinositols.

Biochemical Journal, 1996
Myristate is the exclusive fatty acid species in the glycosyl phosphatidylinositol (GPI) anchor of the Trypanosoma brucei variant surface glycoprotein (VSG). [3H]Myristate can be incorporated into T.
K. Werbovetz, P. T. Englund
semanticscholar   +1 more source

Purification et caractérisation de la D-bêta-hydroxybutyrate déshydrogenase de mitochondries de foie de chamelon [PDF]

, 2000
La D-bêta-hydroxybutyrate déshydrogénase (BDH) est une protéine membranaire mitochondriale. Elle est située sur la face interne de la membrane interne, fortement liée à la membrane. C'est une oxydoréductase à NAD+ (H). Elle intervient dans le métabolisme
Cottin, P., El Kebbaj, M.S., Nasser, B., Poussard, S.   +3 more
core   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

3- and 4-phosphorylated phosphatidylinositols in the aquatic plant Spirodela polyrhiza L.

Biochemical Journal, 1992
Labelling of Spirodela polyrhiza L. plants with [3H]inositol and [32P]Pi yielded a series of phosphoinositides which were identified as PtdIns, PtdIns4P and PtdIns(4,5)P2. In addition, systematic degradation of a phospholipid extract identified PtdIns3P.
C. Brearley, D. Hanke
semanticscholar   +1 more source

Life and times:synthesis, trafficking, and evolution of VSG [PDF]

, 2014
Evasion of the acquired immune response in African trypanosomes is principally mediated by antigenic variation, the sequential expression of distinct variant surface glycoproteins (VSGs) at extremely high density on the cell surface.
Adung’a, Ali, Allen, Anitei, Banerjee, Bangs, Bangs, Barlowe, Barry, Blum, Boothroyd, Borst, Borst, Bridgen, Böhme, Chattopadhyay, Chung, Chung, Cordula Boehm, Cross, Cross, Donelson, El-Sayed, Engstler, Engstler, Ferguson, Ferguson, Field, Field, Field, Field, Field, Freymann, Gabernet-Castello, Gabernet-Castello, Goldshmidt, Grünfelder, Grünfelder, Hall, Heider, Izquierdo, Izquierdo, Jackson, Jackson, Jackson, Jeffries, Ka Fai Leung, Koumandou, Koumandou, Leung, Leung, Liu, Lord, Lustig, Lythgoe, Magez, Manna, Manna, Manthri, Mark C. Field, Mayor, McConnell, McConville, McLintock, Mehlert, Morgan, Morrison, Nagamune, Natesan, Nolan, Overath, Pal, Pal, Parodi, Paul T. Manna, Radwanska, Schwede, Senthil Kumar Natesan, Sevova, Seyfang, Sheader, Silverman, Silverman, Smith, Smith, Thomas, Triggs, Udenfriend, Vickerman, Wang, Wang, Warren, Wickner, Ziegelbauer   +93 more
core   +2 more sources

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

Differential distribution of orthophosphate-32P and glycerol-14C among molecular species of phosphatidylinositols of rat liver in vivo

Journal of Lipid Research, 1971
The incorporation of orthophosphate-32P and glycerol-2-14C into the various species of rat liver phosphatidylinositols as a function of time was determined in vivo. 32P was administered intraperitoneally and glycerol-14C was given intravenously.
B.J. HOLUB, A. KUKSIS
doaj