Results 171 to 180 of about 72,943 (293)

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Understanding lipidomics associations and the lipoprotein-related caveats in population epidemiology. [PDF]

Am J Epidemiol
Zhao S, Ohukainen P, Kettunen J, Järvelin MR, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT, Mäkinen VP, Ala-Korpela M.   +9 more
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Innovative Application of a Multifunctional Sucrose-Gelatin Hydrogel Matrix in Desorption Electrospray Ionization-Mass Spectrometry Imaging. [PDF]

Anal Chem
Ziaco M, Vitale GA, Barra G, Marfella B, dell'Isola M, Albiani F, Grazioso A, Giamundo G, Nuzzo G, Manzo E, Gallo C, Castiglia D, Verrillo L, Miano MG, Cristino L, Conte I, d'Ippolito G, Fontana A.   +17 more
europepmc   +1 more source

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

HIV-1 Tat-induced VAPB disruption initiates a cascade of organellar failures culminating in neuronal lipid accumulation. [PDF]

J Lipid Res
Santerre M, Arjona SP, Cai KQ, Shcherbik N, Sawaya BE.   +4 more
europepmc   +1 more source

Functional screen for subtype specificity of voltage sensor–targeted Kv7 potentiators

British Journal of Pharmacology, EarlyView.
Background and Purpose Voltage‐gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA‐069673 is a N‐aryl benzamide drug that targets the voltage‐sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly ...
Richard Kanyo, Thomas M. Hammond, Alice W. Wang, Caroline K. Wang, Varun Aggarwal, Shawn M. Lamothe, Harley T. Kurata   +6 more
wiley   +1 more source

Response of Psychrotolerant Fungus <i>Mucor flavus</i> to Cell Wall Stress, Induced by Azo Dyes. [PDF]

Int J Mol Sci
Saharova SA, Ianutsevich EA, Danilova OA, Kochkina GA, Tereshina VM.   +4 more
europepmc   +1 more source

Lipidomic Profile of Individuals Infected by <i>Schistosoma mansoni</i>. [PDF]

Int J Mol Sci
Fialho TRS, Dos Santos RA, Tabajara Y, Casaes AC, Macedo MN, Souza BOL, de Jesus KEM, Farias LP, Menezes CA, de Siqueira IC, Sorgi CA, Queiroz A, Oliveira RR.   +12 more
europepmc   +1 more source

Evidence for substrate-cycling of 3-, 3,4-, 4-, and 4,5-phosphorylated phosphatidylinositols in plants.

Biochemical Journal, 1995
C. Brearley, D. Hanke
semanticscholar   +1 more source