Results 281 to 290 of about 22,548 (354)

IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8+ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

Journal of Gastroenterology and Hepatology, EarlyView.
Combined IL‐15 and thymosin α1 therapy reverses CD8+ T cell senescence in hepatocellular carcinoma via a “supply and boost” strategy. Tα1 restores thymic naïve T cell output, while IL‐15 enhances peripheral effector function. Mechanistically, this combination suppresses overactivated PI3K/AKT signaling, restoring antitumor immunity and prolonging ...
Fengtian Wu, Zixuan Guo, Jun Guan, Jia Xu, Yao Chen, Zhi Chen   +5 more
wiley   +1 more source

Ipriflavone From <i>Aquilaria malaccensis</i> Lam. Exosome-Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia-Inducible Factor-α (HIF-α) Hydroxylation Thereby Alleviating Hypoxia-Induced Gastrointestinal Mucosal Ferroptosis. [PDF]

MedComm (2020)
Wang D, Liao X, Wang Y, Wang X, Zhang H, Zeng J, Zhang M, Wang X, Ren F, Wang Y, Li M, Wang W, Lin Q, Gu L, Chang Z, Sheng J.   +15 more
europepmc   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Oral GAD65-L. lactis Vaccine Halts Diabetes Progression in NOD Mice by Orchestrating Gut Microbiota-Metabolite Crosstalk and Fostering Intestinal Immunoregulation. [PDF]

Microorganisms
Zhang S, Wang X, Ma C, Liu T, Qin Q, Shi J, Wu M, Sun J, Hu Y.   +8 more
europepmc   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

The transcription factors TaABI4 and TaNAC‐A1 fine‐tune TaCYP94‐A1 transcription to modulate seed dormancy in wheat

Journal of Integrative Plant Biology, EarlyView.
A module involving the transcription factors TaABI4 and TaNAC‐A1, and the cytochrome P450 TaCYP94‐A1 precisely regulates seed dormancy levels through plant hormone crosstalk, providing targets for improving resistance to pre‐harvest sprouting in wheat.
Litian Zhang, Yuhui Fang, Yunfei Zhou, Xianlai Nie, Shujun Cao, Wei Gao, Yu Wang, Lianghua Dai, Lin Ye, Jie Lu, Chuanxi Ma, Cheng Chang, Haiping Zhang   +12 more
wiley   +1 more source

Phosphatidylinositol 3,5-bisphosphate: A Molecular Switch of Vacuolar Fusion and Fission [PDF]

, 2018
Annie Guo, Gregory E. Miner, Katie Sullivan   +2 more
openalex  

The impact of lipidome on breast cancer: a Mendelian randomization study. [PDF]

Lipids Health Dis
Cao Y, Ai M, Liu C.
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation. [PDF]

J Lipid Res
Song Z, Wang X, Zeng J, Ren F, Wang Y, Li M, Lin Q, Li W, Liao X, Wang D.   +9 more
europepmc   +1 more source