Results 261 to 270 of about 22,548 (354)

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

機能情報部門(臨床利用部門,各部門・附属センターの活動と業績) [PDF]

, 2009
西岡 孝明
core   +2 more sources

GPR55 Antagonist CID16020046 Suppresses Collagen-Induced Rheumatoid Arthritis by Suppressing Th1/Th17 Cells in Mice. [PDF]

Int J Mol Sci
Lee JE, Im DS.
europepmc   +1 more source

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

, 2015
Ivana Mejdrová, Dominika Chalupská, Martin Kögler, Michal Šála, Pavla Plačková, Adriana Bäumlová, Hubert Hřebabecký, Eliška Procházková, Milan Dejmek, Rémi Guillon, Dmytro Strunin, Jan Weber, Gary Lee, Gabriel Birkuš, Helena Mertlíková‐Kaiserová, Evžen Bouřa, Radim Nencka   +16 more
openalex   +1 more source

Spatio-temporal processes in autophagosome-lysosome fusion. [PDF]

Med Rev (2021)
Liu S, Yan H, Diao J, Zhang S, Zhong Q.
europepmc   +1 more source

Comprehensive metabolomic/lipidomic characterization of patients with mitochondrial ATP synthase, short-chain acyl-CoA dehydrogenase and combined variant deficiencies. [PDF]

Heliyon
Dobešová D, Prídavok M, Brumarová R, Kvasnička A, Piskláková B, Ivanovová E, Brennerová K, Šaligová J, Potočňáková Ľ, Drobňaková S, Potočňáková J, Friedecký D.   +11 more
europepmc   +1 more source

ITGA5 as a Dual Regulator of Epithelial‐Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction

Cell Proliferation, EarlyView.
Proteomics and functional validation reveal ITGA5 as a dual promoter of epithelial‐mesenchymal transition and anoikis resistance in human bronchial epithelium: targeting ITGA5 represents a novel therapeutic strategy for asthma airway remodelling. ABSTRACT Airway remodelling is a major contributor to persistent airflow limitation and irreversible lung ...
Ting Wang, Ling Rao, Xiaofang Li, Miaofen Zhang, Huiting Huang, Zhiyan Luo, Gang Liao, Yong Jiang, Shaofeng Zhan, Qiong Liu, Xiufang Huang   +10 more
wiley   +1 more source

Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies. [PDF]

Sports Med Open
Schranner D, Wackerhage H, Weinisch P, Schlegel J, Bremer S, Scherr J, Römisch-Margl W, Riermeier A, Zelger O, Stöcker F, Artati A, Witting M, Krumsiek J, Halle M, Schönfelder M, Kastenmüller G.   +15 more
europepmc   +1 more source