Results 241 to 250 of about 72,943 (293)

Synthesis of short chain phosphatidylinositols

Tetrahedron Letters, 1993
Mary F Roberts
exaly   +2 more sources

Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase

Tetrahedron, 2000
Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Naoko Morisaki, Koji Morita, Asuka Nishikawa, Noriyuki Nakatsu, Yasuhisa Fukui, Yuichi Hashimoto, Ryuichi Shirai   +6 more
openaire   +1 more source

Glycosyl Phosphatidylinositol Anchor

Nephron Experimental Nephrology, 1998
Recently, we and others demonstrated the unique potential for glycosyl phosphatidylinositol (GPI) anchored proteins to transfer from one cell membrane to another in a process we termed ‘painting’. The GPI-anchored proteins were shown to transfer intact and functional.
D L, Kooyman, G W, Byrne, J S, Logan
openaire   +2 more sources

The conformational behaviour of phosphatidylinositol

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990
The temperature dependence of the 1H-NMR spectrum of phosphatidylinositol (PI) in d6-dimethylsulphoxide (DMSO) shows that the hydroxy groups at C2 and at C6 of the inositol ring are internally hydrogen-bonded. This probably implies a trans/gauche conformation for the phosphate/inositol linkage.
R J, Bushby, S J, Byard, P M, Hansbro, D G, Reid   +3 more
openaire   +2 more sources

Phosphatidylinositol synthesis in mycobacteria

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999
The metabolism and synthesis of an important mycobacterial lipid component, phosphatidylinositol (PI), and its metabolites, was studied in Mycobacterium smegmatis and M. smegmatis subcellular fractions. Little is known about the synthesis of PI in prokaryotic cells. Only a cell wall fraction (P60) in M.
Salman M, Lonsdale JT, Besra GS, Brennan PJ   +3 more
openaire   +3 more sources

Synthesis of phosphatidylinositols having various inositol stereoisomers by engineered phospholipase D

Journal of Bioscience and Bioengineering, 2010
Hideo Nakano, Yugo Iwasaki
exaly   +2 more sources

Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer

Cancer Letters, 2012
This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
openaire   +2 more sources

Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides

Bioorganic & Medicinal Chemistry, 2006
Phosphatidylinositol mannosides (PIMs) isolated from mycobacteria have been identified as an important class of glycolipids with significant immune modulating properties. We present here the syntheses of phosphatidylinositol dimannoside (PIM2, 1) and phosphatidylinositol tetramannoside (PIM4, 2) and evaluate their adjuvant properties in a transgenic ...
Gary D, Ainge, Natalie A, Parlane, Michel, Denis, Colin M, Hayman, David S, Larsen, Gavin F, Painter   +5 more
openaire   +2 more sources

Phosphatidylinositol liposomes opsonized by concanavalin a stimulate phosphatidylinositol turnover in macrophages

Biochemical and Biophysical Research Communications, 1986
We have previously found that concanavalin A binds specifically to inositol and phosphatidylinositol. In the present study we demonstrate that binding of concanavalin A to liposomes containing phosphatidylinositol influences the uptake of such liposomes by macrophages.
N M, Wassef, C R, Alving
openaire   +2 more sources

Anti‐inflammatory actions of phosphatidylinositol

European Journal of Immunology, 2011
AbstractChronic inflammatory T‐cell‐mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T‐cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less‐toxic alternatives.
Dieren, Jolanda, Oosterhuis, Ytje, Raatgeep, Rolien, Kortleve, Dicky, Lambers, Margaretha, van der Woude, C.J., Kuipers, Ernst, Snoek, GT, Potman, R, Lambrecht, Bart, Hammad, H (Hamida), Samsom, Janneke, Nieuwenhuis, EES   +12 more
openaire   +3 more sources