Results 241 to 250 of about 73,691 (318)

Genetic Evolution in BRCA1‐Associated Breast Cancer Reveals Early Driver Mutations Shaping Tumor Features and Prognosis

Cancer Science, EarlyView.
Multi‐region sequencing of 57 BRCA1‐associated breast cancers identified TP53 as the dominant initial driver, defining a triple‐negative subgroup with biallelic BRCA1 loss and elevated genomic instability. TP53 truncating mutations were enriched in BRCA1 carriers and linked to reduced HRD, EMT activation, and a trend toward worse survival.
Li Hu, Zhongwu Li, Qiting Wan, Xingyu Liao, Yaxin Zhang, Qian Liu, Xinyun Ding, Hua Meng, Yifan Wu, Jie Sun, Juan Zhang, Lu Yao, Ye Xu, Yuntao Xie   +13 more
wiley   +1 more source

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

The Role of a Newly Synthesized Antimicrobial Peptide (KK)₂-KWWW-NH₂ in Modulating Phosphatidylinositol Monolayer Properties in the Presence of Ascorbic Acid. [PDF]

Int J Mol Sci
Golonka I, Sebastiańczyk A, Łukasiewicz IW, Greber KE, Sawicki W, Musiał W.   +5 more
europepmc   +1 more source

New Treatment Strategy and Future Research Direction for BRAF‐Mutated Cancer

Cancer Science, EarlyView.
Treatment with BRAF inhibitor plus MEK inhibitor is currently used in BRAF‐mutated various malignancies except colorectal cancer, and treatments with BRAF and/or MEK inhibitors and anti‐EGFR antibody are used in BRAF‐mutated colorectal cancer. Despite recent advances in BRAF‐targeted therapies, their efficacy is still limited.
Masanobu Takahashi, Sakura Hiraide Taniguchi, Yuya Yoshida   +2 more
wiley   +1 more source

Variations in the milk lipidomic profile of lactating dairy cows fed the diets containing alfalfa hay versus alfalfa silage. [PDF]

Anim Nutr
Liu K, Chen M, Huang G, Su C, Tang W, Li N, Yang J, Wu X, Si B, Zhao S, Zheng N, Zhang Y, Wang J.   +12 more
europepmc   +1 more source

GPR55 Antagonist CID16020046 Suppresses Collagen-Induced Rheumatoid Arthritis by Suppressing Th1/Th17 Cells in Mice. [PDF]

Int J Mol Sci
Lee JE, Im DS.
europepmc   +1 more source

Phosphoinositide Signaling and Actin Polymerization Are Critical for Tip Growth in the Marine Red Alga <i>Pyropia yezoensis</i>. [PDF]

Plants (Basel)
Irie R, Mikami K.
europepmc   +1 more source

Serum lipidomic changes and sex differences in androgenetic alopecia. [PDF]

Heliyon
Wang S, Li M, Qin S, Wang R, Dong L, Wang S, Xiao F.   +6 more
europepmc   +1 more source

Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies. [PDF]

Sports Med Open
Schranner D, Wackerhage H, Weinisch P, Schlegel J, Bremer S, Scherr J, Römisch-Margl W, Riermeier A, Zelger O, Stöcker F, Artati A, Witting M, Krumsiek J, Halle M, Schönfelder M, Kastenmüller G.   +15 more
europepmc   +1 more source

Roe deer uterine fluid metabolome reveals elevated glycolysis, fatty acid breakdown, and spermidine synthesis upon reactivation from diapause†. [PDF]

Biol Reprod
Elsafadi S, Hankele AK, Giesbertz P, Ulbrich SE.   +3 more
europepmc   +1 more source