Results 331 to 340 of about 77,486 (386)

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer. [PDF]

Metabolites
Liu M, Zhu Y, McIlwain SJ, Deng H, Brasier AR, Ge Y, Kimple ME, Baschnagel AM.   +7 more
europepmc   +1 more source

Causal association of plasma lipidome with lung carcinoma and mediating role of inflammatory proteins: evidence from Mendelian randomization analysis. [PDF]

J Cancer
Yan H, Feng J, Jin X, Zhang Y, Bao C, Zhu C, Feng G.   +6 more
europepmc   +1 more source

The Role of Temperature and Subphase Components in Shaping Selected Physicochemical Properties of the Phosphatidylinositol Monolayer. [PDF]

Int J Mol Sci
Golonka I, Łukasiewicz IW, Sebastiańczyk A, Greber KE, Sawicki W, Musiał W.   +5 more
europepmc   +1 more source

Tandem Mass Spectrometry in Untargeted Lipidomics: A Case Study of Peripheral Blood Mononuclear Cells. [PDF]

Int J Mol Sci
Ventura G, Bianco M, Calvano CD, Losito I, Cataldi TRI.   +4 more
europepmc   +1 more source

Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins [PDF]

Biochemical Society Symposia, 2007
PtdIns is synthesized at the endoplasmic reticulum and its intracellular distribution to other organelles can be facilitated by lipid transfer proteins [PITPs (phosphatidylinositol transfer proteins)]. In this review, I summarize the current understanding of how PITPs are regulated by phosphorylation, how can they dock to membranes to exchange their ...
openaire   +2 more sources

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Oncogenes and Phosphatidylinositol Turnover

Annals of the New York Academy of Sciences, 1986
Products of phosphatidylinositol turnover have recently been implicated as regulators of cell growth and differentiation. Transformation of cells in culture by infection with certain viruses (Rous sarcoma virus, Kirsten sarcoma virus, and polyoma virus) or by transfection with the oncogenes carried by these viruses affect the steady-state level of ...
L. Fleischman, Thomas M. Roberts, David R. Kaplan, Lewis C. Cantley, Suresh B. Chahwala, Brian Schaffhausen, Malcolm Whitman   +6 more
openaire   +3 more sources

Specificity of Acyl Chain Composition of Phosphatidylinositols

Proteomics, 2019
Phosphatidylinositol (PI) lipids have a predominance of a single molecular species present through the organism. In healthy mammals this molecular species is 1‐stearoyl‐2‐arachidonoyl (18:0/20:4) PI.
J. Bozelli, R. Epand
semanticscholar   +1 more source

Phosphorylation of Unnatural Phosphatidylinositols with Phosphatidylinositol 3-Kinase

Tetrahedron, 2000
Phosphatidylinositol analogs (PIC2–PIC18) having a series of saturated fatty acid (C2–C18) at sn-2 position were synthesized and subjected to the phosphorylation reaction with phosphatidylinositol 3-kinase (PI 3-kinase). The reactivity of PIC8 with PI 3-kinase turned out to be comparable to that of natural PI, although PIC18 was not phosphorylated ...
Noriyuki Nakatsu, Yuichi Hashimoto, Koji Morita, Naoko Morisaki, Ryuichi Shirai, Asuka Nishikawa, Yasuhisa Fukui   +6 more
openaire   +2 more sources