Results 341 to 350 of about 77,486 (386)
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Glycosyl Phosphatidylinositol Anchor
Nephron Experimental Nephrology, 1998Recently, we and others demonstrated the unique potential for glycosyl phosphatidylinositol (GPI) anchored proteins to transfer from one cell membrane to another in a process we termed ‘painting’. The GPI-anchored proteins were shown to transfer intact and functional.
Guerard W. Byrne +2 more
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BioEssays, 1994
AbstractCurrently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date.
Rosana Kapeller, Lewis C. Cantley
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AbstractCurrently, a central question in biology is how signals from the cell surface modulate intracellular processes. In recent years phosphoinositides have been shown to play a key role in signal transduction. Two phosphoinositide pathways have been characterized, to date.
Rosana Kapeller, Lewis C. Cantley
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Modulation of phosphatidylinositol turnover by liposomes containing phosphatidylinositol
1987Publisher Summary This chapter discusses the methods for preparing liposomes for coating (opsonizing) the liposomes with immunoglobulin M (IgM) antibodies and complement or opsonizing with concanavalin A (Con A) to promote phagocytosis and resulting increased phosphatidylinositol (PI) turnover, for obtaining and culturing mouse peritoneal macrophages,
Carl R. Alving, Nabila M. Wassef
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Phosphatidylinositol synthesis in mycobacteria
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999The metabolism and synthesis of an important mycobacterial lipid component, phosphatidylinositol (PI), and its metabolites, was studied in Mycobacterium smegmatis and M. smegmatis subcellular fractions. Little is known about the synthesis of PI in prokaryotic cells. Only a cell wall fraction (P60) in M.
Salman M +3 more
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The conformational behaviour of phosphatidylinositol
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1990The temperature dependence of the 1H-NMR spectrum of phosphatidylinositol (PI) in d6-dimethylsulphoxide (DMSO) shows that the hydroxy groups at C2 and at C6 of the inositol ring are internally hydrogen-bonded. This probably implies a trans/gauche conformation for the phosphate/inositol linkage.
Philip M. Hansbro +3 more
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Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols.
Journal of Organic Chemistry, 2003Studies of cellular signal transduction mechanisms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinositols require easy access to these naturally occurring products.
R. Kubiak, K. Bruzik
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Phosphatidylinositol signalling reactions
Seminars in Cell & Developmental Biology, 1998Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these molecules undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3).
Philip W. Majerus, Xiaoling Zhang
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The structural requirement of phosphatidylinositols as substrate of phosphatidylinositol 3-kinase
Tetrahedron Letters, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Noriyuki Nakatsu +6 more
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American Journal of Physiology - Cell Physiology, 2003
Membrane-bound anionic phospholipids such as phosphatidylinositols have the capacity to modulate ATP-sensitive potassium (K(ATP)) channels through a mechanism involving long-range electrostatic interaction between the lipid headgroup and channel. However,
Z. Fan, Lizhi Gao, Wenxia Wang
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Membrane-bound anionic phospholipids such as phosphatidylinositols have the capacity to modulate ATP-sensitive potassium (K(ATP)) channels through a mechanism involving long-range electrostatic interaction between the lipid headgroup and channel. However,
Z. Fan, Lizhi Gao, Wenxia Wang
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Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer
Cancer Letters, 2012This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP ...
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