Results 351 to 360 of about 77,486 (386)

Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides

Bioorganic & Medicinal Chemistry, 2006
Phosphatidylinositol mannosides (PIMs) isolated from mycobacteria have been identified as an important class of glycolipids with significant immune modulating properties. We present here the syntheses of phosphatidylinositol dimannoside (PIM2, 1) and phosphatidylinositol tetramannoside (PIM4, 2) and evaluate their adjuvant properties in a transgenic ...
David S. Larsen, Gavin F. Painter, Michel Denis, Colin M. Hayman, Gary D. Ainge, Gary D. Ainge, Natalie A. Parlane   +6 more
openaire   +3 more sources

ChemInform Abstract: Synthesis of Phosphatidylinositol Mannosides. [PDF]

ChemInform, 2013
AbstractThe cell envelope of mycobacterial species, which include the deadly Mycobacterium tuberculosis, carries unique glycan structures that are crucial for infection and bacterial survival. Notable among these glycans are the structurally‐related phosphatidylinositol mannosides (PIMs), lipomannan, and lipoarabinomannan. The immunoactivities of these
Medel Manuel L. Zulueta, Pratap S. Patil, Shang-Cheng Hung   +2 more
openaire   +2 more sources

Phosphatidylinositol liposomes opsonized by concanavalin a stimulate phosphatidylinositol turnover in macrophages

Biochemical and Biophysical Research Communications, 1986
We have previously found that concanavalin A binds specifically to inositol and phosphatidylinositol. In the present study we demonstrate that binding of concanavalin A to liposomes containing phosphatidylinositol influences the uptake of such liposomes by macrophages.
Nabila M. Wassef, Carl R. Alving
openaire   +3 more sources

Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C

Journal of Cellular Physiology, 2015
Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways which modulate many cellular functions including cell proliferation, cell differentiation, apoptosis, and membrane trafficking. An array of kinases, phosphatases, and lipases acts on PI creating an important number of second messengers involved in different ...
POLI, ALESSANDRO, BILLI, ANNA MARIA, MONGIORGI, SARA, RATTI, STEFANO, Mccubrey, James A., Suh, Pann Ghill, COCCO, LUCIO ILDEBRANDO, RAMAZZOTTI, GIULIA   +7 more
openaire   +5 more sources

Anti‐inflammatory actions of phosphatidylinositol

European Journal of Immunology, 2011
AbstractChronic inflammatory T‐cell‐mediated diseases such as inflammatory bowel disease (IBD) are often treated with immunosuppressants including corticosteroids. In addition to the intended T‐cell suppression, these farmacons give rise to many side effects. Recently, immunosuppressive phospholipids have been proposed as less‐toxic alternatives.
Hamida Hammad, Jolanda M. van Dieren, H C Rolien Raatgeep, Y. Simons-Oosterhuis, C. Janneke van der Woude, Bart N. Lambrecht, Ron Potman, Dicky J. Lindenbergh-Kortleve, Margaretha E H Lambers, Edward E. S. Nieuwenhuis, Edward E. S. Nieuwenhuis, Ernst J. Kuipers, Gerry T Snoek, Janneke N. Samsom   +13 more
openaire   +4 more sources

Analysis of the neutral glycan fractions of glycosyl-phosphatidylinositols by thin-layer chromatography.

Analytical Biochemistry, 1993
The radiolabeled neutral glycan fractions of both glycosyl-phosphatidylinositol (GPI) protein anchors and related glycolipids were analyzed by thin-layer chromatography on silica gel 60, using butanol:ethanol:water (4:3:3, v/v) or a combination of 1 ...
P. Schneider, J. Ralton, M. McConville, M. Ferguson   +3 more
semanticscholar   +1 more source

Kinetics of phosphatidylinositol-specific phospholipase C with vesicles of a thiophosphate analogue of phosphatidylinositol

Chemistry and Physics of Lipids, 1996
1,2-Dimyristoyloxypropane-3-thiophospho(1D-1-myo-inositol) (D-thio-DMPI) was synthesized as a substrate for the continuous spectrophotometric assay of phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus cereus. Release of thio-diglyceride is followed by a coupled reaction with 4,4'-dithiopyridine to produce a chromophore, 4 ...
Matthew J. Kirsch, Carol Banovetz, Elizabeth K. Hendrickson, H.Stewart Hendrickson   +3 more
openaire   +3 more sources

Reversed-phase ion-pair high-performance liquid chromatography of phosphatidylinositols

, 1991
Reversed-phase ion-pal, high-performance liquid chromatographic (HPLC) separations of molecular species of phosphatidylinositols (PI) were studied. Mobile phases of acetonitrile-methanol-water containing various tetraalkylammonium phosphates (TAAP) were ...
S. Abidi, T. Mounts, K. A. Rennick
semanticscholar   +1 more source

Characterization of phosphatidylinositol and phosphatidylinositol-4-phosphate kinases in human neutrophils.

The Journal of Immunology, 1988
Abstract Phosphodiesteric cleavage of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) is required for transmembrane signaling by chemoattractants in human polymorphonuclear leukocytes (PMN). Considering the importance of PtdIns-4,5-P2 as a reservoir for second messenger substances, we have characterized the enzyme system that ...
M C, Pike, C, Arndt
openaire   +2 more sources

In vivo effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositols in resting and anti-CD3-activated lymphocytes.

Alcoholism: Clinical and Experimental Research, 1993
Fatty acid composition of phosphatidylinositols was analyzed in peripheral blood lymphocytes from nine alcoholic patients who were well nourished and without severe acute and chronic liver disease, before and after stimulation with anti-CD3 antibody. Six
S. Hrelia, P. Biagi, A. Bordoni, M. Celadon, C. Rossi, E. Castelli, F. Foschi, G. Gasbarrini, G. Stefanini   +8 more
semanticscholar   +1 more source