Results 91 to 100 of about 9,975 (285)

Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage

Haematologica, 2020
Macaques are emerging as a critical animal model in transfusion medicine, because of their evolutionary similarity to humans and perceived utility in discovery and translational science. However, little is known about the metabolism of Rhesus macaque red
Davide Stefanoni, Hye Kyung H. Shin, Jin Hyen Baek, Devin P. Champagne, Travis Nemkov, Tiffany Thomas, Richard O. Francis, James C. Zimring, Tatsuro Yoshida, Julie A. Reisz, Steven L. Spitalnik, Paul W. Buehler, Angelo D’Alessandro   +12 more
doaj   +1 more source

Cytotoxic Effects of Methylgerambullin and Bis(Methylthiomethyl)-Disulphide (SB) on T-Lymphoblastic Leukemic Cell Line (Cem-SS) [PDF]

, 2000
The cytotoxic effects of 2 sulphur-containing compounds were studied on Tlymphoblastic leukemic cell line. Methylgerambullin is believed to be a new sulphone derived from a methylthiopropenoic acid isolated from Glycosmis calcicola (family Rutaceae ...
Mohamed, Shar Mariam
core  

Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse [PDF]

, 2015
Background: Obese adults are prone to develop metabolic and cardiovascular diseases. Furthermore, over-weight expectant mothers give birth to large babies who also have increased likelihood of developing metabolic and cardiovascular diseases. Fundamental
A Matsakas, A Matsakas, A Matsakas, A Matsakas, A Raben, A Roca-Rivada, AC McPherron, AC McPherron, AD Kriketos, AD Kriketos, AJ Wade, B Zhao, BC Song, C Cooper, C Zhang, CE Brown, CL Mendias, CN Hales, DJ Barker, DJ Barker, DS Mosher, ED Rosen, F Backhed, F Zurlo, G Aldini, G Liebisch, GP Holloway, GP Holloway, H Abe, H Amthor, H Lees, J Abou Mrad, J He, JF Tong, JP Thyfault, JR Swann, JT Tansey, K Relizani, KM Chan, KR Westerterp, M Qatanani, M Scherer, M Scherer, M Schuelke, MW Hamrick, O Beckonert, P Bostrom, Q Wang, R Kohen, RE Williams, RM Avena, S Girgenrath, T Guo, T Westergaard, T Westergaard, T Westergaard, TP Ciaraldi, V Matyash, VA Narkar, YX Wang   +59 more
core   +2 more sources

Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging

Advanced Science, EarlyView.
Cell death is important in both the development and treatment of cancer. In this study, it is demonstrated for the first time that a specific measurement of the transmembrane water exchange rate using magnetic resonance imaging can be used as an early marker of cell death in mammalian cells, in animals and in human patients. Abstract Cell death plays a
Athanasia Kaika, Luca Nagel, Ulrike Höckendorf, Bangwen Xie, Geoffrey J. Topping, Mathias Schillmaier, Irina Beer, Frits H. A. van Heijster, Julian Rauch, Tristan A. Kuder, Sandra Sühnel, Bernd Erber, Christian Lohrmann, Simone Ballke, Thomas Metzler, Katja Steiger, Philipp J. Jost, Natalia P. Ivleva, Philipp Paprottka, Jonathan Nadjiri, Kevin M. Brindle, Wolfgang A. Weber, Franz Schilling   +22 more
wiley   +1 more source

Advancing Target Identification of Nitrated Phospholipids in Biological Systems by HCD Specific Fragmentation Fingerprinting in Orbitrap Platforms

Molecules, 2020
Nitrated phospholipids have recently been detected in vitro and in vivo and associated with beneficial health effects. They were identified and quantified in biological samples by lipidomics methodologies using liquid chromatography-collision-induced ...
Bruna Neves, Sofia Duarte, Pedro Domingues, Dolores Pérez-Sala, Maria Manuel Oliveira, Maria do Rosário Domingues, Tânia Melo   +6 more
doaj   +1 more source

ОСОБЕННОСТИ АУТОЛИТИЧЕСКИХ ПЕРЕСТРОЕК ЛИПИДНОГО КОМПОНЕНТА МОЗЖЕЧКА БЕЛЫХ КРЫС IN VITRO [PDF]

, 2005
C применением микротонкослойной хроматографии изучены изменения липидного компонента в ткани мозжечка крыс в динамике аутолиза in vitro в стерильном физиологическом растворе. Основным изменениям в аутолизирующемся мозжечке подвергаются фосфатидилхолины и
Луцкая, Н.В.
core  

Untargeted metabolomic analysis of human serum samples associated with different levels of red meat consumption: A possible indicator of type 2 diabetes? [PDF]

, 2016
Red meat consumption has been associated with negative health effects. A study to identify biomarkers of meat consumption was undertaken using serum samples collected from combining high resolution mass spectrometry (UPLC-QTof-MS) and chemometrics. Using
Brennan, Sarah F., Cantwell, Marie M., Carrizo, Daniel, Chevallier, Olivier P., Cuskelly, Geraldine, Elliott, Christopher T., Woodside, Jayne V.   +6 more
core   +1 more source

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging.

PLoS Neglected Tropical Diseases, 2020
Schistosomes are human pathogens causing the neglected tropical disease schistosomiasis, which occurs worldwide in (sub-)tropical regions. This infectious disease is often associated with poverty, and more than 700 million people are at risk of infection.
Patrik Kadesch, Thomas Quack, Stefanie Gerbig, Christoph G Grevelding, Bernhard Spengler   +4 more
doaj   +1 more source