Results 91 to 100 of about 9,580 (237)

Identification of Tim4 as a phosphatidylserine receptor [PDF]

Nature, 2007
In programmed cell death, a large number of cells undergo apoptosis, and are engulfed by macrophages to avoid the release of noxious materials from the dying cells. In definitive erythropoiesis, nuclei are expelled from erythroid precursor cells and are engulfed by macrophages.
Masanori Miyanishi, Masanori Miyanishi, Yasuo Uchiyama, Masato Koike, Toshio Kitamura, Kazutoshi Tada, Shigekazu Nagata   +6 more
openaire   +3 more sources

Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imaging [PDF]

, 2014
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the US. The majority (~85%) of GISTs possess gain-of-function mutations in KIT or PDGFRA, causing constitutive activation of the kinase receptor.
Devarajan, Karthik, Godwin, Andrew K, Hensley, Harvey, Johnson, James R, Piwnica-Worms, David, Rink, Lori, von Mehren, Margaret   +6 more
core   +2 more sources

Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging.

PLoS Neglected Tropical Diseases, 2020
Schistosomes are human pathogens causing the neglected tropical disease schistosomiasis, which occurs worldwide in (sub-)tropical regions. This infectious disease is often associated with poverty, and more than 700 million people are at risk of infection.
Patrik Kadesch, Thomas Quack, Stefanie Gerbig, Christoph G Grevelding, Bernhard Spengler   +4 more
doaj   +1 more source

Sex-specific lipidomic signatures in aortic valve disease reflect differential fibro-calcific progression

Nature Communications
Fibro-calcific aortic valve disease (FCAVD) is the most common valvular heart disease manifesting in pathological remodeling of the aortic valve (AV) leaflets, ultimately leading to aortic stenosis. Although dyslipidemia is a driver of FCAVD pathogenesis,
Patricia Prabutzki, Michele Wölk, Julia Böttner, Zhixu Ni, Sarah Werner, Holger Thiele, Jürgen Schiller, Petra Büttner, Florian Schlotter, Maria Fedorova   +9 more
doaj   +1 more source

Structural Determination of Lysosphingomyelin-509 and Discovery of Novel Class Lipids from Patients with Niemann–Pick Disease Type C [PDF]

, 2019
Niemann–Pick disease type C (NPC) is an autosomal recessive disorder caused by the mutation of cholesterol-transporting proteins. In addition, early treatment is important for good prognosis of this disease because of the progressive neurodegeneration ...
Abe, A, Eto, Y, Fujii, K, Higaki, K, Iwahori, A, Jinnoh, I, Maekawa, M, Mano, N, Mashima, R, Matsumoto, Y, Narita, A, Ohno, K, Okuyama, T, Ozeki, Y, Saigusa, D, Shimoda, K, T Clayton, P, Takahashi, H, Tomioka, Y, Yamaguchi, H, Yamauchi, S   +20 more
core  

Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet

Journal of Lipid Research, 2021
Recent studies have highlighted an important role for lysophosphatidylcholine acyltransferase 3 (LPCAT3) in controlling the PUFA composition of cell membranes in the liver and intestine.
Thibaut Bourgeois, Antoine Jalil, Charles Thomas, Charlène Magnani, Naig Le Guern, Thomas Gautier, Jean-Paul Pais de Barros, Victoria Bergas, Hélène Choubley, Loïc Mazzeo, Louise Menegaut, Lorène Josiane Lebrun, Kévin Van Dongen, Marion Xolin, Tony Jourdan, Chloé Buch, Jérome Labbé, Philippe Saas, Laurent Lagrost, David Masson, Jacques Grober   +20 more
doaj  

Lipid ratios as a marker for red blood cell storage quality and as a possible explanation for donor gender differences in storage quality [PDF]

, 2020
Background and objectives Red blood cells that are stored for transfusions as red cell concentrates (RCCs) undergo changes during the storage period, culminating in the lysis of the cells. The goal of this work is to find markers that are linked to
Bieback, Karen, Brenner‐Weiss, Gerald, Kirschhöfer, Frank, Melzak, Kathryn A., Muth, Marius   +4 more
core   +2 more sources

Global metabolomic profiling of uterine leiomyomas [PDF]

, 2017
Background: Uterine leiomyomas can be classified into molecularly distinct subtypes according to their genetic triggers: MED12 mutations, HMGA2 upregulation, or inactivation of FH.
A Jurecka, AE Harper, Annukka Pasanen, AR Mullen, Auli Karhu, B Ogretmen, C Frezza, C Gorrini, CL Martin, DA Tennant, DD Baird, DN Markowski, DW Stovall, Eevi Kaasinen, EF Schoenmakers, ER Cardozo, Esa Pitkänen, EW Gerner, FJ Debruyne, G Allegri, Hanna-Riikka Heinonen, HR Heinonen, HR Heinonen, IP Tomlinson, J Adam, J Adam, J Du, J Nikkanen, Jari Sjöberg, JC Gómez-Fernández, JE Vance, JI Young, JM Cárcamo, K Kämpjärvi, L Zheng, LA Wise, Lauri A Aaltonen, M Gilden, M Malik, M Malik, M Mehine, M Mehine, Miika Mehine, N Mäkinen, Nanna S Sarvilinna, NE Braverman, Netta Mäkinen, NN Pavlova, Oskari Heikinheimo, P Mazzei, PA Ott, PJ Pollard, R Kohen, R Lehtonen, R Mesnage, R Teperino, Ralf Bützow, RR Broaddus, S Brakta, S Tregoning, SF Cramer, SM Fendt, T Camerini, WH Catherino, WH Tong, Y Benjamini, Y Mitsuishi, Y Yang   +67 more
core   +1 more source

Phosphatidylserin Decarboxylase in Pflanzen

, 2003
1 Titelblatt, Widmung und Inhaltsverzeichnis 2 Einleitung 2.1 Pflanzliche Lipide 5 2.2 Synthese und Funktion von Phosphatidylserin und Phosphatidylethanolamin 5 2.3 Pyruvoyl-abhängige Decarboxylasen 8 2.4 Phosphatidylserin Decarboxylase 13 2.5 Verwendete Modellorganismen und ihre Mutanten 16 2.6 Fragestellung 17 3 Material und Methoden 3.1 Geräte 19 3 ...
openaire   +1 more source

Dispersion and stabilization of cochleate nanoparticles [PDF]

, 2017
Cochleates, calcium-stabilized membrane rolls of nanoscale diameter, promise a unique and efficient way of delivering lipid-soluble drugs, proteins or nucleic acids into biological systems because they protect the encapsulated material against enzymatic ...
Bozó, Tamás, Bóta, Attila, Kellermayer, Miklós Sándor Zoltán, Mihály, Judith, Wacha, András   +4 more
core   +1 more source