Results 101 to 110 of about 4,332 (253)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Lysosome‐Targeted Squaramide Anion Transporters

Chemistry – A European Journal, EarlyView.
Lysosome‐targeted squaramide anion transporters elicit different biological effects depending on the targeting group employed. ABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines.
Elba Feo, Edward York, Anthony Thai, William G. Ryder, Daniel A. McNaughton, Philip A. Gale   +5 more
wiley   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Correlation of Anti‐Phosphatidylserine/Prothrombin and Anti‐Phosphatidylserine Antibodies with Pregnancy Outcomes

American Journal of Reproductive Immunology
ABSTRACTBackgroundThe objective of this study was to investigate the clinical relevance of anti‐prothrombin antibodies (aPT) and anti‐phosphatidylserine/prothrombin antibodies (aPS/PT) in relation to pregnancy outcomes and coagulation parameters, as well as immune markers.MethodsWe retrospectively analyzed 477 pregnant women with experienced at least ...
Junmiao Xiang, Yundong Pan, Ruru Bao, Zhuhua Cai   +3 more
openaire   +2 more sources

Increased calcification by erythrophagocytosis in aortic valvular interstitial cells

ESC Heart Failure, Volume 12, Issue 2, Page 1469-1473, April 2025.
Abstract Background Calcific aortic valve disease (CAVD) progresses over time to severe aortic stenosis and eventually heart failure. Recent evidence indicates that intraleaflet haemorrhage (ILH) strongly promotes CAVD progression. However, it remains poorly understood how it mechanistically contributes to valvular calcification.
Zihan Qin, Magnus Bäck, Anders Franco‐Cereceda, Sven‐Christian Pawelzik   +3 more
wiley   +1 more source

Exploring the Anticancer Activity of Ruthenium(II)–Arene and Copper(I) Complexes Bearing N‐Heterocyclic Carbene Ligands Containing Azido, Pyridinium, and Ethisterone‐Derived Triazole Groups

European Journal of Inorganic Chemistry, EarlyView.
A versatile library of backbone‐functionalized N‐heterocyclic carbene (NHC) ligands was developed and efficiently converted into Cu(I) and Ru(II) NHC complexes, demonstrating that ligand functionalization strongly modulates anticancer activity, with Cu(I)–NHC species showing potent and selective antiproliferative effects against ovarian and breast ...
Alessia Schiavo, Chiara Tupini, Nicola Demitri, Ilaria Lampronti, Thomas Scattolin   +4 more
wiley   +1 more source

Seed lipid profiles of perennial ryegrass: Global patterns and differentiation of ryegrass cultivars and Epichloë endophytes

Grassland Research, EarlyView.
Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao, Wei Zhang, Wade J. Mace, Christine R. Voisey, David E. Hume, Richard D. Johnson, Sushma Prakash   +6 more
wiley   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

iMeta, EarlyView.
Early‐pregnancy microbiome and lipidome profiling identified a microbiome‐glycosphingolipid axis associated with later gestational diabetes mellitus (GDM) risk. In the prospective pregnancy cohort, women who later developed GDM showed altered gut microbial composition, enriched microbial lipid biosynthesis pathways, and broad plasma lipidomic changes ...
Zhonghan Sun, Chang He, Xiaonan Ma, Ping Wu, Tianlei Wang, Jiaying Yuan, Yanni Pu, Xiaofeng Zhou, Zhendong Mei, Huiling Song, Yetong Wang, Haiyan Yue, Yuanqing Fu, Jusheng Zheng, An Pan, Da Chen, Shangyu Hong, Xiong‐Fei Pan, Yan Zheng   +18 more
wiley   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source