Results 131 to 140 of about 31,210 (332)
Dynamics of phagocytosis mediated by phosphatidylserine
Biochemical Society Transactions, 2022 Phagocytosis triggered by the phospholipid phosphatidylserine (PS) is key for the removal of apoptotic cells in development, tissue homeostasis and infection. Modulation of PS-mediated phagocytosis is an attractive target for therapeutic intervention in the context of atherosclerosis, neurodegenerative disease, and cancer.
openaire +2 more sources
Advances in Cancer Immunotherapy for Solid Tumors
Advanced Science, EarlyView.Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz +1 more
wiley +1 more source
On the functional ordering of biomembranes : Implications for drug binding [PDF]
, 2010 Cells are packed with membrane structures, defining the inside and outside, and the different subcellular compartments. These membranes consisting mainly of phospholipids have a variety of functions in addition to providing a permeability barrier for ...
Parry, Mikko
core
Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins [PDF]
, 2018 Permeabilization of the plasma membrane represents an important threat for any cell, since it compromises its viability by disrupting cell homeostasis.
Etxaniz Iriondo, Asier +3 more
core +3 more sources
Crystal structure of a human plasma membrane phospholipid flippase
Journal of Biological Chemistry, 2019 ATP11C, a member of the P4-ATPase flippase, translocates phosphatidylserine from the outer to the inner plasma membrane leaflet, and maintains the asymmetric distribution of phosphatidylserine in the living cell.
H. Nakanishi +6 more
semanticscholar +1 more source
Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley +1 more source
Investigating cytokinesis failure as a strategy in cancer therapy [PDF]
, 2016 Effective therapeutics exploit common characteristics shared amongst cancers. As many cancers present chromosomal instability (CIN), one possible approach to treat these cancers could be to increase their CIN above a threshold that would affect their ...
D'Avino, PP, McKenzie, C
core +2 more sources
Advanced NanoBiomed Research, EarlyView.Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq +5 more
wiley +1 more source
Cytotoxic Effects of Methylgerambullin and Bis(Methylthiomethyl)-Disulphide (SB) on T-Lymphoblastic Leukemic Cell Line (Cem-SS) [PDF]
, 2000 The cytotoxic effects of 2 sulphur-containing compounds were studied on Tlymphoblastic leukemic cell line. Methylgerambullin is believed to be a new sulphone derived from a methylthiopropenoic acid isolated from Glycosmis calcicola (family Rutaceae ...
Mohamed, Shar Mariam
core
Hydrodynamics of Diffusion in Lipid Membrane Simulations
, 2018 By performing molecular dynamics simulations with up to 132 million coarse-grained particles in half-micron sized boxes, we show that hydrodynamics quantitatively explains the finite-size effects on diffusion of lipids, proteins, and carbon nanotubes in ...
Hummer, Gerhard +2 more
core +1 more source