Results 141 to 150 of about 31,210 (332)

The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration [PDF]

, 2019
Macrophages are crucial for tissue homeostasis. Based on their activation, they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO).
Alessio Torcinaro, Elisabetta Ferraro, Fielding RA, Francesca De Santa, Galván-Peña S, Hard GC, Huang X, Kawanishi N, Laura Vitiello, Munder M, Ménégaut L, Ohtsu A, Tidball JG, Zhang X   +13 more
core   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype

Scientific Reports, 2019
Heightened threats for nuclear terrorism using improvised nuclear devices (IND) necessitate the development of biodosimetry assays that could rapidly assess thousands of individuals.
E. Laiakis, M. P. Canadell, V. Grilj, A. Harken, G. Garty, G. Astarita, D. Brenner, L. Smilenov, A. Fornace   +8 more
semanticscholar   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Structure and Nanomechanics of Model Membranes by Atomic Force Microscopy and Spectroscopy: Insights into the Role of Cholesterol and Sphingolipids [PDF]

, 2017
Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate.
Carlá, Francesco, Comin, Fabio, Costa, Luca, Giannotti, Marina Ines, Gumí Audenis, Berta, Sanz Carrasco, Fausto   +5 more
core   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse [PDF]

, 2015
Background: Obese adults are prone to develop metabolic and cardiovascular diseases. Furthermore, over-weight expectant mothers give birth to large babies who also have increased likelihood of developing metabolic and cardiovascular diseases. Fundamental
A Matsakas, A Matsakas, A Matsakas, A Matsakas, A Raben, A Roca-Rivada, AC McPherron, AC McPherron, AD Kriketos, AD Kriketos, AJ Wade, B Zhao, BC Song, C Cooper, C Zhang, CE Brown, CL Mendias, CN Hales, DJ Barker, DJ Barker, DS Mosher, ED Rosen, F Backhed, F Zurlo, G Aldini, G Liebisch, GP Holloway, GP Holloway, H Abe, H Amthor, H Lees, J Abou Mrad, J He, JF Tong, JP Thyfault, JR Swann, JT Tansey, K Relizani, KM Chan, KR Westerterp, M Qatanani, M Scherer, M Scherer, M Schuelke, MW Hamrick, O Beckonert, P Bostrom, Q Wang, R Kohen, RE Williams, RM Avena, S Girgenrath, T Guo, T Westergaard, T Westergaard, T Westergaard, TP Ciaraldi, V Matyash, VA Narkar, YX Wang   +59 more
core   +2 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

EM23, a natural sesquiterpene lactone from Elephantopus mollis H.B.K., induces apoptosis in human myeloid leukemia cells through thioredoxin- and reactive oxygen species-mediated signaling pathways

Frontiers in Pharmacology, 2016
Elephantopus mollis H.B.K. (EM) is a traditional herbal medicine with multiple pharmacological activities. However, the efficacy of EM in treating human leukemia is currently unknown.
Hongyu eLi, Manmei eLi, Guocai eWang, Fangyuan eShao, Wenbo eChen, Chao eXia, Sheng eWang, Yaolan eLi, Guangxiong eZhou, Zhong eLiu   +9 more
doaj   +1 more source

Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometry imaging.

PLoS Neglected Tropical Diseases, 2020
Schistosomes are human pathogens causing the neglected tropical disease schistosomiasis, which occurs worldwide in (sub-)tropical regions. This infectious disease is often associated with poverty, and more than 700 million people are at risk of infection.
Patrik Kadesch, Thomas Quack, Stefanie Gerbig, Christoph G Grevelding, Bernhard Spengler   +4 more
doaj   +1 more source