Results 31 to 40 of about 9,580 (237)

Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging

Scientific Reports, 2021
Duchenne muscular dystrophy (DMD) is a common and severe X-linked myopathy, characterized by muscle degeneration due to altered or absent dystrophin. DMD has no effective cure, and the underlying molecular mechanisms remain incompletely understood.
Ivana Dabaj, Justine Ferey, Florent Marguet, Vianney Gilard, Carole Basset, Youssef Bahri, Anne-Claire Brehin, Catherine Vanhulle, France Leturcq, Stéphane Marret, Annie Laquerrière, Isabelle Schmitz-Afonso, Carlos Afonso, Soumeya Bekri, Abdellah Tebani   +14 more
doaj   +1 more source

Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast [PDF]

Traffic, 2014
Over the past two decades, most of the genes specifying lipid synthesis and metabolism in yeast have been identified and characterized. Several of these biosynthetic genes and their encoded enzymes have provided valuable tools for the genetic and biochemical dissection of interorganelle lipid transport processes in yeast.
Wayne R. Riekhof, Muthukumar Kannan, Dennis R. Voelker   +2 more
openaire   +3 more sources

Metabolic Heavy Isotope Labeling to Study Glycerophospholipid Homeostasis of Cultured Cells

Bio-Protocol, 2017
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains ...
Satu Hänninen, Pentti Somerharju, Martin Hermansson   +2 more
doaj   +1 more source

Metabolomic profiling predicts outcome of rituximab therapy in rheumatoid arthritis. [PDF]

, 2016
ObjectiveTo determine whether characterisation of patients' metabolic profiles, utilising nuclear magnetic resonance (NMR) and mass spectrometry (MS), could predict response to rituximab therapy. 23 patients with active, seropositive rheumatoid arthritis
Boyle, David, Guma, Monica, Kavanaugh, Arthur, Lodi, Alessia, Sweeney, Shannon R, Tiziani, Stefano, Wang, Bo   +6 more
core   +2 more sources

Nanoelectropulse-Induced Phosphatidylserine Translocation [PDF]

Biophysical Journal, 2004
Nanosecond, megavolt-per-meter, pulsed electric fields induce phosphatidylserine (PS) externalization, intracellular calcium redistribution, and apoptosis in Jurkat T-lymphoblasts, without causing immediately apparent physical damage to the cells. Intracellular calcium mobilization occurs within milliseconds of pulse exposure, and membrane phospholipid
Martin A. Gundersen, Cheryl M. Craft, P. Thomas Vernier, Yinghua Sun, Laura Marcu, Laura Marcu   +5 more
openaire   +2 more sources

Untargeted UPLC-MS Profiling Pipeline to Expand Tissue Metabolome Coverage: Application to Cardiovascular Disease. [PDF]

, 2015
Metabolic profiling studies aim to achieve broad metabolome coverage in specific biological samples. However, wide metabolome coverage has proven difficult to achieve, mostly because of the diverse physicochemical properties of small molecules ...
Alun H. Davies, Beltran A., Cubbon S., Elaine Holmes, Eliasson M., Elizabeth J. Want, Fahy E., Geier F. M., Gika H. G., Gika H. G., Giorgis Isaac, Gray N., Hao Z., Idborg H., Ismail N. A., Ivanisevic J., Jeremy K. Nicholson, Kanehisa M., Masson P., Mirnezami R., Muzaffar A. Anwar, Naz S., Nicholson J. K., Panagiotis A. Vorkas, Plumb R. S., Saric J., Schmidt C., Smith C. A., Spagou K., Spagou K., Vorkas P. A., Waldram A., Want E. J., Wishart D. S.   +33 more
core   +5 more sources

Sensing Phosphatidylserine in Cellular Membranes [PDF]

Sensors, 2011
Phosphatidylserine, a phospholipid with a negatively charged head-group, is an important constituent of eukaryotic cellular membranes. On the plasma membrane, rather than being evenly distributed, phosphatidylserine is found preferentially in the inner leaflet. Disruption of this asymmetry, leading to the appearance of phosphatidylserine on the surface
Sergio Grinstein, Jason G. Kay
openaire   +4 more sources

Procoagulant Activity of Blood and Endothelial Cells via Phosphatidylserine Exposure and Microparticle Delivery in Patients with Diabetic Retinopathy

Cellular Physiology and Biochemistry, 2018
Background/Aims: The mechanisms for thrombosis in diabetic retinopathy (DR) are complex and need to be further elucidated. The purpose of this study was to test phosphatidylserine (PS) exposure on microparticles (MPs) and MP-origin cells from the ...
Ying Su, Jingli Chen, Zengxiang Dong, Yan Zhang, Ruishuang Ma, Junjie Kou, Feng Wang, Jialan Shi   +7 more
doaj   +1 more source

Regulation of Anti-Phosphatidylserine Antibodies [PDF]

Immunity, 2003
The degree of heavy chain (H) editing, the types of Vkappa editors, and the pattern of Jkappa usage are correlated with a range of the affinity of anti-DNA. This range was determined by the number and location of arginine (R) residues in the VH. We, here, changed a key arginine residue in the VH of anti-DNA transgene to glycine, which sharply reduces ...
Marko Z. Radic, Hong Cao, Martin Weigert, Yufei Jiang, Hui Li, Eline T. Luning Prak   +5 more
openaire   +3 more sources

Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). [PDF]

, 2018
Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers ...
Amen, Beldon, Cajka, Choi, Evans, Fernandis, Gosain, Guest, Guo, Jiang, Koh, Korting, Larjava, McDaniel, Morgan, Nagai, Sasso, Schwamborn, Sen, Stephenson, Thomsen, Tsuji, Yang, Yin   +23 more
core   +2 more sources