Results 291 to 300 of about 187,817 (376)

Use of LC‐MS to characterize host cell protein removal during depth filtration

Biotechnology Progress, EarlyView.
Abstract The removal of host cell proteins (HCPs) is crucial in biopharmaceutical production, as residual impurities can impact product safety and efficacy. While a number of studies have demonstrated that depth filtration can provide significant HCP removal, there is little information on its effectiveness in removing specific HCPs.
Liang‐Kai Chu, Ehsan Espah Borujeni, Xuankuo Xu, Andrew L. Zydney   +3 more
wiley   +1 more source

Aluminum phosphide poisoning with Brugada ECG: a case report highlighting diagnostic challenges arising from patient nondisclosure. [PDF]

Int J Emerg Med
Sadeq MA, Dawood MS, Ghorab RMF, Aggour MSR.   +3 more
europepmc   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

A Bench-Stable Fluorophosphine Nickel(0) Complex and Its Catalytic Application. [PDF]

Angew Chem Int Ed Engl
Flecken F, Neyyathala A, Grell T, Hanf S.   +3 more
europepmc   +1 more source

Chemoenzymatic route towards a de novo enantioselective total synthesis of (S)‐baclofen based on metal‐catalyzed hydroformylation and enzymatic transamination

ChemBioChem, Accepted Article.
This study explores the chemoenzymatic synthesis of (S)‐baclofen, which involves a sequential combination of transition metal‐catalysis and biocatalysis. The synthesis approach starts from a readily accessible cinnamic acid ester that is converted using a rhodium‐based hydroformylation catalyst towards the corresponding chiral aldehyde.
Feodor Belov, Hannah Bork, Luise Hänel, Manideep V. Kollipara, Matthias Höhne, Harald Gröger, Jan von Langermann   +6 more
wiley   +1 more source

Fluorine-modified passivator for efficient vacuum-deposited pure-red perovskite light-emitting diodes. [PDF]

Light Sci Appl
Liu N, Liu Z, Huang Y, Du P, Zhang X, Leng Y, Luo J, Du J, Tang J.   +8 more
europepmc   +1 more source

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

ChemBioChem, EarlyView.
Cell‐penetrating peptide (CPP)‐conjugated folic acid mediates efficient internalization of folic acid that is independent of the presence of proton‐coupled folate transporter (PCFT) on the intestinal cells. CPP‐conjugated folic acid demonstrates superior cellular uptake at all studied pH and in the presence of PCFT inhibitors and shows enhanced ...
Vineet Kumar Mishra, Rheal Towner, Juan Carlos Rodriguez‐Lecompte, Marya Ahmed   +3 more
wiley   +1 more source

Unlocking the potential of azide-phosphine Staudinger reaction for the synthesis of poly(arylene iminophosphorane)s and materials therefrom. [PDF]

Commun Chem
Kotnik T, Debuigne A, De Winter J, Huš M, Pintar A, Kovačič S.   +5 more
europepmc   +1 more source

A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations

ChemBioChem, EarlyView.
Site‐specifically phosphorylated isoforms of the tumor suppressor p53 – encompassing all seven known phosphorylation sites within the TAD1 domain –are created upon optimization of semisynthesis protocols. This “designer" p53 library enabled validation of phosphorylation‐specific p53 antibodies and revealed epitope masking by phosphorylation in commonly
Mateusz Hess, Jonathan H. Davies, Sofia Margiola, Sonja Schneider, Thomas Hicks, Nishant Rai, Manuel M. Müller   +6 more
wiley   +1 more source

Chiral PCN pincer Ni(ii) complex-catalyzed asymmetric hydrophosphination of 2-alkenoylpyridines with diphenylphosphine. [PDF]

RSC Adv
Li JG, Qiu BB, Jiang H, Song MP, Gong JF.   +4 more
europepmc   +1 more source