Results 1 to 10 of about 52,049 (355)
Decreased frontal lobe phosphocreatine levels in methamphetamine users [PDF]
Drug and Alcohol Dependence, 2012 Mitochondria-related mechanisms have been suggested to mediate methamphetamine (METH) toxicity. However, changes in brain energetics associated with high-energy phosphate metabolism have not been investigated in METH users. Phosphorus-31 ((31)P) magnetic resonance spectroscopy (MRS) was used to evaluate changes in mitochondrial high energy phosphates ...
Young-Hoon Sung +13 more
semanticscholar +5 more sources
Population Pharmacokinetics of Phosphocreatine and Its Metabolite Creatine in Children With Myocarditis [PDF]
Frontiers in Pharmacology, 2020 Objective: This study aimed to develop a parent-metabolite joint population pharmacokinetic model to characterize the pharmacokinetic (PK) profile for phosphocreatine (PCr) and its metabolite creatine (Cr) in children with myocarditis and to use this ...
Huan He +6 more
doaj +2 more sources
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine [PDF]
Nature, 2021 Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes1-3. Recent data have indicated that thermogenic fat cells use creatine to stimulate futile substrate cycling, dissipating chemical energy as heat4,5.
Yizhi Sun +16 more
openaire +3 more sources
In vivo imaging of phosphocreatine with artificial neural networks
Nature Communications, 2020 Phosphocreatine plays a vital role in cellular energetic homeostasis, but there are no routine diagnostic tests to noninvasively map the distribution with clinically relevant spatial resolution.
Lin Chen +9 more
doaj +2 more sources
The Protective Effect of Cx43 Protein-Mediated Phosphocreatine on Myocardial Ischemia/Reperfusion Injury [PDF]
Cardiology Research and Practice, 2021 Objectives. To verify the protective effect of phosphocreatine on myocardium in an ischemic model and the possible mechanism of action. Methods. The model of myocardial ischemia/reperfusion (I/R) was established by the ligation balloon method. 30 SD rats
Chen-xi Wang +11 more
doaj +2 more sources
Клинический разбор в общей медицине, 2023 The authors describe a clinical observation of cardiotoxicity of anticancer targeted therapy in a young patient with HER2neu-positive breast cancer. The results of instrumental examinations demonstrating manifestations of cardiotoxicity are presented ...
Andrey L. Pylev +2 more
doaj +2 more sources
Skin Research and Technology, 2007 Background/purpose: The skin has the unique ability to survive ischemia associated with skin grafts, flaps and hair transplantation procedures. Spectroscopic data later confirmed by chromatography, immunohistochemistry and molecular biology techniques identified the presence of large quantities of phosphocreatine in human skin.
Alexander Zemtsov
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Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles
Einstein (São Paulo), 2014 Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis.
Lucas Guimarães-Ferreira
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PLoS ONE, 2012 A broad spectrum of beneficial effects has been ascribed to creatine (Cr), phosphocreatine (PCr) and their cyclic analogues cyclo-(cCr) and phospho-cyclocreatine (PcCr).
Małgorzata Tokarska-Schlattner +10 more
openalex +3 more sources
PHOSPHOCREATINE IMPROVES MUSCLE MICROCIRCULATION DURING EXERCISE [PDF]
Revista Brasileira de Medicina do Esporte, 2021 ABSTRACT Introduction: Phosphate (CP) its biosynthesis begins with the kidney. Glycocianine was synthesized from glycocianine, then methylated in the liver, and finally formed in each tissue. Objective: To study the effects of phosphatic acid in exercise training.
MA Lei
openalex +4 more sources