ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher +12 more
wiley +1 more source
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I [PDF]
, 2007 Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically and symptomatically similar to Huntington disease.
Banos +30 more
core +3 more sources
Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism. [PDF]
PLoS ONE, 2017 Mitochondrial DNA (mtDNA), the discrete genome which encodes subunits of the mitochondrial respiratory chain, is present at highly variable copy numbers across cell types.
Emily Booth Warren +3 more
doaj +1 more source
European Journal of Heart Failure, EarlyView.Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard +29 more
wiley +1 more source
Transcription start site scanning and the requirement for ATP during transcription initiation by RNA polymerase II [PDF]
, 2016 Saccharomyces cerevisiae RNA polymerase (Pol) II locates transcription start sites (TSS) at TATA-containing promoters by scanning sequences downstream from the site of preinitiation complex formation, a process that involves the translocation of ...
Fishburn, James +2 more
core +2 more sources
Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]
, 2020 BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U. +7 more
core +1 more source
Neuroprotective Effect of Phosphocreatine on Focal Cerebral Ischemia-Reperfusion Injury
Journal of Biomedicine and Biotechnology, 2012 Phosphocreatine (PCr) is a natural compound, which can donate high-energy phosphate group to ADP to synthesize ATP, even in the absence of oxygen and glucose. At present, it is widely used in cardiac and renal ischemia-reperfusion (IR) disease.
Tiegang Li, Nana Wang, Min Zhao
semanticscholar +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Influence of ischemia on the discharge rate in motor units during a sustained submaximal contraction [PDF]
, 2018 Motor unit discharge patterns were observed under ischemic and non-ischemic conditions in the tibialis anterior during two sessions approximately 48 hours apart.
Gregg, Robert Henry
core +1 more source
Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine
Glia, EarlyView.Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani +15 more
wiley +1 more source